T-SPOT.TB Reactivity in Southern African Children With and Without in Utero HIV Exposure

Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guerin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

Automated summary

Infants exposed to HIV but not infected have a higher risk of infectious morbidity compared to those who are unexposed and uninfected. We conducted a study on 418 Bacillus Calmette-Guerin vaccinated sub-Saharan African infants aged 9-18 months to compare the prevalence of TB infection using T-SPOT.TB. The prevalence of TB infection was low and did not differ based on HIV exposure status.