Journal
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
Volume 64, Issue 5, Pages 998-1005Publisher
WILEY-BLACKWELL
DOI: 10.1111/jgs.14090
Keywords
herpesvirus; frailty; mortality; herpes simplex virus; cytomegalovirus
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Funding
- National Institutes of Health, National Institute on Aging through the Johns Hopkins Older Americans Independence Center [K23 AG033113, P30 AG021334]
- T. Franklin Williams Research Scholars Award - Atlantic Philanthropies
- American Geriatrics Society
- John A. Hartford Foundation
- Association of Subspecialty Professors
- John A. Hartford Foundation's Center of Excellence in Geriatric Medicine Scholars Award
- Johns Hopkins Biology of Healthy Aging Program
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ObjectivesTo examine the relationship between herpesvirus infections and mortality and incident frailty risks in community-dwelling older women. DesignNested prospective cohort study. SettingWomen's Health and Aging Studies I and II. ParticipantsCommunity-dwelling older women aged 70 to 79 (n = 633). MeasurementsBaseline serum antibody (immunoglobulin G) levels against four herpesviruses (herpes simplex virus types 1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV), 7 Epstein-Barr virus (EBV)), 3-year incident frailty rates, and 5-year mortality. ResultsWomen seropositive for HSV-1 and HSV-2, but not VZV and EBV, had higher risk of 3-year incident frailty (HSV-1: hazard ratio (HR) = 1.90, 95% confidence interval (CI) = 0.96-3.74; HSV-2: HR = 2.10, 95% CI = 1.05-4.37) and 5-year mortality (HR = 1.73, 95% CI = 0.93-3.20; HR = 1.80, 95% CI = 0.94-3.44, respectively) than seronegative women. Incremental increases in serum HSV-1 and HSV-2 antibody levels were associated with incrementally higher risks of incident frailty and mortality. After adjustment for potential confounders, only higher serum HSV-2 antibody level was independently predictive of higher risk of mortality in older women (for each unit increase in antibody index, HR = 1.47, 95% CI = 1.05-2.07). ConclusionHSV-1 and HSV-2 antibody levels are not independently associated with risk of incident frailty in older women. Only HSV-2 antibody level is independently predictive of 5-year mortality risk, with each incremental increase in the antibody level adding further risk.
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