Role of apolipoproteins in the pathogenesis of obesity

Obesity is a state presented by excessive accumulation and abnormal distribution of body fat, with metabolic disorders being one of its distinguishing features. Obesity is associated with dyslipidemia and apolipoproteins are important structural components of plasma lipoproteins. Apolipoproteins influence the progression of obesity by a variety of mechanisms including lipid metabolism, energy expenditure and inflammatory response. In this review, we discuss the role of apolipoproteins in obesity, mechanisms of action as well as their potential as new therapeutic targets.

Automated summary

Obesity is characterized by excessive accumulation and abnormal distribution of body fat, accompanied by metabolic disorders. Dyslipidemia is associated with obesity and apolipoproteins play an important role in plasma lipoprotein structure. Apolipoproteins influence obesity progression through mechanisms such as lipid metabolism, energy expenditure, and inflammatory response. This review discusses the role of apolipoproteins in obesity, their mechanisms of action, and their potential as novel therapeutic targets.