Journal
CIRCULATION RESEARCH
Volume 132, Issue 9, Pages 1203-1225Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.123.322136
Keywords
immune response; lymphatic endothelial cells; lymphatic system; lymph node; lymphoid tissue; Peyer's patches; spleen
Ask authors/readers for more resources
Secondary lymphoid organs, such as lymph nodes, have specialized niches that optimize the encounter of naive lymphocytes with antigens and antigen-presenting cells, leading to optimal adaptive immune responses. Lymphatic vessels of lymphoid organs are specialized to perform various tasks, including antigen presentation, immune cell trafficking, activation modulation, and survival factor provision. Recent studies have provided insights into the molecular basis of this specialization, opening avenues for understanding immune-vascular interactions and their applications.
Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and compartmentalized niches. These niches are optimized to facilitate the encounter of naive lymphocytes with antigens and antigen-presenting cells, enabling optimal generation of adaptive immune responses. Lymphatic vessels of lymphoid organs are uniquely specialized to perform a staggering variety of tasks. These include antigen presentation, directing the trafficking of immune cells but also modulating immune cell activation and providing factors for their survival. Recent studies have provided insights into the molecular basis of such specialization, opening avenues for better understanding the mechanisms of immune-vascular interactions and their applications. Such knowledge is essential for designing better treatments for human diseases given the central role of the immune system in infection, aging, tissue regeneration and repair. In addition, principles established in studies of lymphoid organ lymphatic vessel functions and organization may be applied to guide our understanding of specialization of vascular beds in other organs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available