Journal
CHINESE MEDICAL JOURNAL
Volume 136, Issue 6, Pages 683-689Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CM9.0000000000002627
Keywords
All-cause death; All-cause mortality; Atrial fibrillation; Blood pressure; Diastolic blood pressure; Hypertension; Systolic blood pressure
Categories
Ask authors/readers for more resources
This study aimed to assess the effect of baseline blood pressure on all-cause mortality in patients with atrial fibrillation (AF). The results showed that a systolic blood pressure (SBP) ≤ 110 mmHg or > 160 mmHg and a diastolic blood pressure (DBP) < 70 mmHg were associated with an increased risk of all-cause mortality. Therefore, excessively low blood pressure may not be an optimal target for patients with AF.
Background:The ideal blood pressure (BP) target for patients with atrial fibrillation (AF) is still unclear. The present study aimed to assess the effect of the baseline BP on all-cause mortality in patients with AF.Methods:This registry study included 20 emergency centers across China and consecutively enrolled patients with AF from 2008 to 2011. All participants were followed for 1 year +/- 1 month. The primary endpoint was all-cause mortality.Results:During the follow-up, 276 (13.9%) all-cause deaths occurred. Kaplan-Meier curves showed that a systolic blood pressure (SBP) <= 110 mmHg or >160 mmHg was associated with a higher risk of all-cause mortality (log-rank test, P = 0.014), and a diastolic blood pressure (DBP) <70 mmHg was associated with the highest risk of all-cause mortality (log-rank test, P = 0.002). After adjusting for confounders, the multivariable Cox regression model suggested that the risk of all-cause mortality was increased in the group with SBP <= 110 mmHg (hazard ratio [HR], 1.963; 95% confidence interval [CI], 1.306-2.951), and DBP <70 mmHg (HR, 1.628; 95% CI, 1.163-2.281). In the restricted cubic splines, relations between baseline SBP or DBP and all-cause mortality showed J-shaped associations (non-linear P P = 0.010, respectively). The risk of all-cause mortality notably increased at a lower baseline SBP and DBP.Conclusions:Having a baseline SBP <= 110 mmHg or DBP <70 mmHg was associated with a significantly higher risk of all-cause mortality in patients with AF. An excessively low BP may not be an optimal target for patients with AF.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available