Indocyanine green-/TLR7 agonist-constructed thermosensitive liposome for low-temperature PTT induced synergistic immunotherapy of colorectal cancer

Article Chemistry, Multidisciplinary

Applying nanotechnology to boost cancer immunotherapy by promoting immunogenic cell death

Lvqin Fu et al.

Summary: Tumor immunogenic cell death (ICD) is a death mode of tumor cells that can enhance tumor immune responses. The application of nanotechnology can improve drug delivery and enhance the efficacy of immunotherapy.

CHINESE CHEMICAL LETTERS (2022)

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Review Pharmacology & Pharmacy

Nano-sized drug delivery systems to potentiate the immune checkpoint blockade therapy

Man Kyu Shim et al.

Summary: This review discusses recent advances in using nano-sized drug delivery systems (Nano-DDS) to enhance immune checkpoint blockade (ICB) therapy by reversing cold tumors with an immunosuppressive tumor microenvironment (ITM) into immunogenic hot tumors. It classifies the types of immunogenic cell death (ICD) inducers that initiate or enhance anti-tumor immune responses and highlights their extensive combination with immune modulators using Nano-DDS.

EXPERT OPINION ON DRUG DELIVERY (2022)

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Article Chemistry, Multidisciplinary

Nanocarrier Co-formulation for Delivery of a TLR7 Agonist plus an Immunogenic Cell Death Stimulus Triggers Effective Pancreatic Cancer Chemo-immunotherapy

Lijia Luo et al.

Summary: A lipid bilayer-coated mesoporous silica nanoparticle platform was developed for co-delivery of a TLR agonist and a chemotherapeutic agent, which improved the immune landscape in pancreatic cancer and achieved a positive therapeutic outcome.

ACS NANO (2022)

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Article Engineering, Biomedical

Intelligent MoS2-CuO heterostructures with multiplexed imaging and remarkably enhanced antitumor efficacy via synergetic photothermal therapy/ chemodynamic therapy/ immunotherapy

Fan Jiang et al.

Summary: The MoS2-CuO nanoplatform designed in this study integrates multimodal imaging and therapeutic functions for cancer treatment. It is capable of enhancing antitumor efficacy through a combination of photothermal therapy, chemodynamic therapy, and immunotherapy, while also generating strong antitumor immune responses for effectively eliminating primary and metastatic tumors.

BIOMATERIALS (2021)

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Article Biochemistry & Molecular Biology

Construction of pH/glutathione responsive chitosan nanoparticles by a self-assembly/self-crosslinking method for photodynamic therapy

Ziming Yang et al.

Summary: A novel pH/glutathione multi-responsive chitosan nanoparticles material has been successfully designed and prepared for photodynamic therapy, providing a new strategy for targeted photosensitizer delivery. The nanoparticles have high ICG entrapment and loading efficiency, achieving multi-responsive ICG release in tumor cells with strong therapeutic effects.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Nanoscience & Nanotechnology

Recent Advancements in Nanomedicine for 'Cold' Tumor Immunotherapy

Qinjun Chen et al.

Summary: Despite the high clinical success rate of current anticancer immunotherapies using immune check-point inhibitors (ICIs), many patients with 'cold' tumors still respond poorly to ICI therapy due to insufficient T cell infiltration and low immunogenicity. Advances in precision medicine and nanotechnology have shown promise in improving treatment for these patients by targeting the immunosuppressive tumor immune microenvironment in cold tumors.

NANO-MICRO LETTERS (2021)

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Review Multidisciplinary Sciences

Low-Temperature Photothermal Therapy: Strategies and Applications

Xiulin Yi et al.

Summary: This study summarises strategies for achieving low-temperature PTT using nanomaterials, introduces the synthesis, characteristics, and applications of these nanoplatforms, and discusses the synergistic cancer therapeutic effect of combining PTT with other treatment modalities.

RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Synergistic Effect of Photothermally Targeted NIR-Responsive Nanomedicine-Induced Immunogenic Cell Death for Effective Triple Negative Breast Cancer Therapy

Vellingiri Yasothamani et al.

Summary: TNBC patients currently lack approved targeted therapy, leading to high mortality rates. Developing a new nanotherapeutic approach of combinational therapy, such as HA-PANi/R837 nanoparticles, shows promise in improving treatment outcomes.

BIOMACROMOLECULES (2021)

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Article Engineering, Biomedical

PolyTLR7/8a-conjugated, antigen-trapping gold nanorods elicit anticancer immunity against abscopal tumors by photothermal therapy-induced in situ vaccination

Xiang Liu et al.

Summary: The study demonstrates that PTT-induced in situ vaccination cancer therapy can effectively combat disseminated and metastatic tumors, showing promising anti-tumor immunity in mice. The use of gold nanorods covalently coupled with polyTLR7/8a and MMP-2-sensitive R9-PEG resulted in the formation of nanovaccines directly in vivo, activating dendritic cells and enhancing antitumor T-cell responses. Peritumoral administration of low-dose multifunctional AuNRs followed by noninvasive NIR laser irradiation inhibits local and distant metastatic tumors in mice, suggesting a potent therapeutic strategy for advanced cancers.

BIOMATERIALS (2021)

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Review Chemistry, Inorganic & Nuclear

Recent advances in immunotherapy, immunoadjuvant, and nanomaterial-based combination immunotherapy

Benqing Zhou et al.

Summary: Cancer immunotherapy has become a major treatment modality, utilizing immunoadjuvants and nanoplatforms to enhance efficacy. Different types of immunotherapies can be divided into five categories, each with its own limitations.

COORDINATION CHEMISTRY REVIEWS (2021)

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Review Medicine, Research & Experimental

Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view

Xingyue Huang et al.

Summary: The review summarized cutting-edge strategies in combining nano-based photothermal therapy (PTT) with immunotherapy for cancer treatment, which includes four categories of combination strategies. Various photothermal agents and nanoplatforms characteristics, as well as the immunological mechanisms for the synergism, were introduced in detail. Existing challenges and future prospects in combined PTT and immunotherapy were also discussed.

THERANOSTICS (2021)

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Review Medicine, Research & Experimental

Nano-immunotherapy for each stage of cancer cellular immunity: which, why, and what?

Shiyi Zuo et al.

Summary: Immunotherapy, especially nano-immunotherapy, plays a crucial role in combating cancer by targeting different stages of cancer cellular immunity. The combination of nanotechnology and immunotherapy enhances efficacy and reduces toxicity, but faces challenges in clinical applications.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

Application of phototherapeutic-based nanoparticles in colorectal cancer

Jiaxin Yan et al.

Summary: Colorectal cancer is the third most commonly diagnosed malignancy and the second leading cause of cancer death worldwide. Photosensitizers play an important role in the treatment of CRC, but they are often associated with limitations.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Medicine, Research & Experimental

Turning cold tumors into hot tumors by improving T-cell infiltration

Yuan-Tong Liu et al.

Summary: Immunotherapy, particularly through immune checkpoint inhibitors, has significantly improved the treatment of malignant tumors by enhancing T cell infiltration into tumors. Understanding the mechanisms underlying cold tumors, which lack T cell infiltration, is crucial to improving immunotherapy efficacy. Strategies to transform cold tumors into hot tumors and increase T cell infiltration are discussed, along with the potential of nanomedicines in enhancing tumor immunotherapy.

THERANOSTICS (2021)

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Article Chemistry, Multidisciplinary