Journal
CHINESE CHEMICAL LETTERS
Volume 34, Issue 10, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2023.108315
Keywords
Supramolecular effect; Heme analog; Pocket effect; Axial ligation; Ring distortion
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In this study, a trans-ortho-di-strapped zinc porphyrin with dome-like deformation was synthesized by thermodynamically controlling the formation of trans- precursor of porphyrinogen. Its single-crystal structure revealed the unique features of creating two secondary coordination sphere (SCS) bulks, maintaining a unique dome deformation, and making atomic out-of-plane deviation. This metallic complex integrates at least three key features, making it an ideal heme analog.
Heme responsible for the dioxygen fixation, transport and conversion is a metalloporphyrin complex highly dependent on its diverse geometry of ligand. In this work, a trans-ortho-di-strapped zinc porphyrin with dome-like deformation was synthesized by thermodynamically controlling the formation of trans- precursor of porphyrinogen. Its single-crystal structure demonstrated that the asymmetric treatment of porphyrin achieves three goals of creating two secondary coordination sphere (SCS) bulks, maintaining a unique dome deformation, and making atomic out-of-plane deviation. In this way, this metallic complex integrates at least three key features of the pocket structure, the differentiated axial ligations, and the ring distortion, making it an ideal heme analog. & COPY; 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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