Outcomes From More Than 1 Million People Screened for Lung Cancer With Low-Dose CT Imaging

BACKGROUND: Lung cancer screening (LCS) with low-dose CT (LDCT) imaging was rec-ommended in 2013, making approximately 8 million Americans eligible for LCS. The de-mographic characteristics and outcomes of individuals screened in the United States have not been reported at the population level.RESEARCH QUESTION: What are the outcomes among people screened and entered in the American College of Radiology's Lung Cancer Screening Registry compared with those of trial participants? STUDY DESIGN AND METHODS: This was a cohort study of individuals undergoing baseline LDCT imaging for LCS between 2015 and 2019. Predictors of adherence to annual screening were computed. LDCT scan interpretations by Lung Imaging Reporting and Data System (Lung-RADS) score, cancer detection rates (CDRs), and stage at diagnosis were compared with National Lung Cancer Screening Trial data.RESULTS: Adherence was 22.3%, and predictors of poor adherence included current smoking status and Hispanic or Black race. On baseline screening, 83% of patients showed negative results and 17% showed positive screening results. The overall CDR was 0.56%. The percentage of people with cancer detected at baseline was higher in the positive Lung-RADS categories at 0.4% for Lung-RADS category 3, 2.6% for Lung-RADS category 4A, 11.1% for Lung-RADS category 4B, and 19.9% for Lung-RADS category 4X. The cancer stage distribution was similar to that observed in the National Lung Cancer Screening Trial, with 53.5% of patients receiving a diagnosis of stage I cancer and 14.3% with stage IV cancer. Underreporting into the registry may have occurred.INTERPRETATION: This study revealed both the positive aspects of CT scan screening for lung cancer and the challenges that remain. Findings on CT imaging were correlated accurately with lung cancer detection using the Lung-RADS system. A significant stage shift toward early-stage lung cancer was present. Adherence to LCS was poor and likely contributes to the lower than expected cancer detection rate, all of which will impact the outcomes of patients undergoing screening for lung cancer.CHEST 2023; 164(1):241-251

Automated summary

This study examines the outcomes of lung cancer screening with low-dose CT imaging and finds that adherence to screening is poor and the detection rate of early-stage lung cancer is lower than expected. However, CT imaging results are accurately associated with lung cancer detection. These findings will impact the outcomes of patients undergoing lung cancer screening.