Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202300144
Keywords
alpha-(trifluoromethyl)styrenes; hydroamination; N-beta-trifluoromethyl 2-pyridones; regioselectivity; 2-pyridones
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A convenient method for the synthesis of N-beta-CF3-substituted 2-pyridones via hydroamination of alpha-(trifluoromethyl)styrenes with 2-pyridones was developed. The reaction proceeded smoothly at room temperature, yielding a variety of N-(beta-trifluoromethyl-beta-arylethyl)pyridin-2(1H)-ones in moderate to good yields with excellent N-regioselectivity.
A novel and facile method for the synthesis of N-beta-CF3-substituted 2-pyridones via hydroamination of alpha-(trifluoromethyl)styrenes with 2-pyridones was described. The reaction proceeded smoothly at room temperature, affording a variety of N-(beta-trifluoromethyl-beta-arylethyl)pyridin-2(1H)-ones in moderate to good yields with excellent N-regioselectivity.
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