Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV Latency-Reversing Agents

Structurally simplified analogues of ansellone A, in which the decalin skeleton is replaced with a lipophilic chain, were prepared and their HIV latency-reversing activities biologically evaluated. In particular, two analogues bearing ether and alkenyl side chains, respectively, showed comparable activities to that of ansellone A. Each of the simplified compounds was easily synthesized using Prins cyclisation chemistry.

Automated summary

Structurally simplified analogues of ansellone A were synthesized by replacing the decalin skeleton with a lipophilic chain, and their HIV latency-reversing activities were evaluated. Two analogues with ether and alkenyl side chains showed comparable activities to ansellone A. The simplified compounds were easily synthesized using Prins cyclisation chemistry.