Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 59, Issue 3, Pages 524-528Publisher
SPRINGER
DOI: 10.1007/s10600-023-04041-4
Keywords
indole alkaloids; endophytic fungus Aspergillus fumigatus; anti-TMV activity
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Two new indole alkaloids, 1-(5-prenyl-1H-indol-3-yl)propan-2-one (1) and 1-(6-methoxy-5-prenyl-1H-indol-3-yl)propan-2-one (2), along with five known ones (3-7), were isolated from the fermentation products of a cigar tobacco-derived endophytic fungus Aspergillus fumigatus. Their structures were determined using spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 exhibited potential anti-tobacco mosaic virus (anti-TMV) activities, with inhibition rates of 26.5% and 28.8%, respectively.
Two new indole alkaloids, 1-(5-prenyl-1H-indol-3-yl)propan-2-one (1) and 1-(6-methoxy-5-prenyl-1H-indol-3-yl)propan-2-one (2), along with five known ones (3-7) were isolated from the fermentation products of a cigar tobacco-derived endophytic fungus Aspergillus fumigatus. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-tobacco mosaic virus (anti-TMV). The results showed that compounds 1 and 2 exhibited potential anti-TMV activities with inhibition rates of 26.5 and 28.8%, respectively.
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