Highly Sensitive and Ultrastable Lateral Flow Immunoassay Based on Polydopamine-Coated Aggregation-Induced Emission Fluorescent Microspheres with Excellent Fluorescence Performance and Biofriendly Coupling Strategy

Editorial Material Multidisciplinary Sciences

Mechanistic connotations of restriction of intramolecular motions (RIM)

Yujie Tu et al.

NATIONAL SCIENCE REVIEW (2021)

Article Chemistry, Analytical

Boronate affinity-assisted oriented antibody conjugation on quantum dot nanobeads for improved detection performance in lateral flow immunoassay

Tong Lin et al.

Summary: The study presents a novel method for preparing immunoprobes that improves antibody orientation and biological activity, resulting in significant enhancement in lateral flow immunoassay performance.

MICROCHEMICAL JOURNAL (2021)

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Article Chemistry, Analytical

Fluorescent paper strip immunoassay with carbon nanodots@silica for determination of human serum amyloid A1

Mulya Supianto et al.

Summary: A novel fluorescent paper strip immunoassay utilizing carbon nanodots@silica as a label was developed for quantitative measurements of hSAA1 in human serum. The method is clinically significant for lung cancer diagnosis and can detect hSAA1 concentrations ranging from 0.1 to 5 nM.

MICROCHIMICA ACTA (2021)

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Article Chemistry, Analytical

NIR-II emissive lateral flow immunoassay for accurate determination of tumor marker in hemolysis

Rui Chen et al.

Summary: The NIR-II LFIA platform offers high-accuracy and high-sensitivity detection of AFP in hemolytic blood samples with a wide dynamic range and a low detection limit, making it a promising screening platform for early disease detection in complex matrix samples.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Food Science & Technology

Ensuring food safety using fluorescent nanoparticles-based immunochromatographic test strips

Yuhao Wu et al.

Summary: This review comprehensively summarizes the application potentials and critical roles of novel luminescent nanomaterials as signal reporters in current ICTS systems for ensuring food safety. Further improvement should focus on high-quality luminescent nanomaterials, ultra-sensitive detection, multiplexing and multimode sensing, accurate quantification, and intelligent signal reading.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

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Article Engineering, Biomedical

One-for-all phototheranostics: Single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy

Haifei Wen et al.

Summary: This study successfully constructs a versatile theranostic agent with aggregation-induced emission (AIE) characteristics, providing both multimodality imaging and therapy functions. The theranostic agent exhibits good biocompatibility and excellent therapeutic efficacy, making it a promising platform for practical cancer diagnosis and treatment.

BIOMATERIALS (2021)

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Article Biophysics

AIEgens enabled ultrasensitive point-of-care test for multiple targets of food safety: Aflatoxin B1 and cyclopiazonic acid as an example

Xiaofeng Hu et al.

Summary: Food safety is a crucial issue for human health, and fluorescent nanomaterials have been used in point-of-care tests (POCT). However, previous materials may reduce detection sensitivity, while aggregation-induced emission luminogens (AIEgens) show promise for enhancing sensitivity and throughput. AIEgens-based lateral-flow biosensors have been developed for on-site detection of mycotoxins with rapid response times and high sensitivity in peanut matrices.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Chemistry, Multidisciplinary

Aggregate Materials beyond AlEgens

Zheng Zhao et al.

Summary: Aggregate materials focus on materials constituted by more than a single entity, such as dimers, trimers, or multimers formed by the group of same molecules or mixtures formed by different molecules. These materials are among the most commonly existing forms in human daily life and research in this area has shown that aggregate control can be a versatile and effective strategy to endow materials with rich properties and functions.

ACCOUNTS OF MATERIALS RESEARCH (2021)

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Review Chemistry, Multidisciplinary