Journal
CHEMISTRY LETTERS
Volume 52, Issue 4, Pages 299-302Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.230056
Keywords
Nitroarenes; Denitrative coupling; Mizoroki-Heck reaction
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A Pd-catalyzed denitrative intramolecular Mizoroki-Heck reaction of nitroarenes with alkenes has been developed, providing a convergent synthetic method for benzo-fused cyclic compounds.
A Pd-catalyzed denitrative intramolecular Mizoroki-Heck reaction of nitroarenes with alkenes was developed. Pd/BrettPhos is an effective catalyst for this transformation, producing 5-and 6-membered cyclic products such as indenes and benzopyrans. Since a tethered-alkene group can be introduced onto the nitroarene core through nucleophilic aromatic substitution (SNAr), the present denitrative reaction would provide a convergent synthetic method for benzo-fused cyclic compounds.
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