Journal
CHEMISTRY & BIODIVERSITY
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202201135
Keywords
A; salina larvae; cytotoxicity; E; bivonae extract; GC; MS analysis; HEK293 cell lines; oxidative biomarkers
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In this research, the effects of Euphorbia bivonae extract compounds on the lethality of brine shrimp Artemia salina and the proliferation of embryonic cell lines (HEK293) were investigated. The GC/MS analysis revealed the presence of sitosterol, euphol, and lupeol in the E. bivonae ethanolic extract. The extract showed cytotoxic effects on both A. salina larvae and HEK293 cell lines, suggesting the potential application of these compounds as natural antiproliferatives.
In this research article, we investigated the effect of Euphorbia bivonae extract compounds on the lethality of brine shrimp Artemia salina and on embryonic cell lines (HEK293) proliferation. Our GC/MS analysis revealed that the E. bivonae ethanolic extract contained essentially sitosterol, euphol, and lupeol. The 24-h LC50 was determined using the probit analysis method (LC50=357.11 mg l(-1)). Depending on this cytotoxicity test result, E. bivona extract induced a significant increase in Superoxide Dismutase (SOD), Catalase (CAT), Glutathione-Peroxidase (GPx) activities, and lipid peroxidation (LPO) in A. salina larvae. In addition, the cytotoxicity effect of this extract had proved against the HEK293 cell lines in vitro. We suggest that the three compounds of E. bivonae extract (sitosterol, euphol, and lupeol) are the most responsible for this cytotoxicity. The possible application of this extract as an alternative natural antiproliferative is considered.
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