Chemical Synthesis Enables the Configurational Determination of Myristriol, a Highly Oxygenated Phenylpropanoid from Myristica fragrans Houtt

A new phenylpropanoid, myristriol (1), along with 11 known ones were isolated from the seed kernel of Myristica fragrans Houtt. Their chemical structures were clearly elucidated by extensive spectroscopic analysis. In which, the relative configuration of 1 was finally determined as erythro-1 by comparison the NMR data of two synthetic erythro- and threo-diastereoisomers with that of natural 1.

Automated summary

A new phenylpropanoid compound named myristriol (1) was isolated from the seed kernel of Myristica fragrans Houtt, along with 11 known compounds. The chemical structures were determined through extensive spectroscopic analysis. The relative configuration of compound 1 was confirmed as erythro-1 by comparing its NMR data with those of synthetic erythro- and threo-diastereoisomers.