☆ 4.8 Review

The Dawn of a New Era: Targeting the Undruggables with Antibody-Based Therapeutics

CHEMICAL REVIEWS (2023)

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Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry

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Rob C. Oslund et al.

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Philip C. Robinson et al.

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Spatially resolved cell tagging and surfaceome labeling via targeted photocatalytic decaging

Ziqi Liu et al.

Summary: In this study, we report a extracellular-targeted photocatalytic decaging system for spatially resolved cell tagging and surface proteome profiling. By conjugating an antibody to the photocatalysis system, we achieved targeted photocatalytic decaging on cell surfaces, allowing selective cell tagging in cell mixture and tumor xenografts. Furthermore, we combined quinone methide decaging chemistry with the photocatalytic system to achieve spatially resolved membrane proteome profiling, revealing potential protein clusters. Finally, we expanded our strategy to photocatalytic prodrug decaging for selective tumor cell killing.

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Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

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Acta Pharmaceutica Sinica B (2022)

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Radiolabeled Antibodies for Cancer Imaging and Therapy

Sagun Parakh et al.

Summary: Monoclonal antibodies have the unique ability to target tumor-cell antigens, making them useful in delivering radioisotopes to tumor sites and in radioimmunotherapy. While the treatment of solid tumors remains challenging, various strategies are being investigated to improve the efficacy of radioimmunotherapy.

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Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System

Ildiko Szabo et al.

Summary: Cell-penetrating peptides (CPPs) are a diverse group of molecules with promising potential for transporting compounds into cells, but face challenges such as non-specific internalization and rapid elimination from the body. Despite growing understanding of the mechanisms involved, predicting and designing the cell-penetrating properties of CPPs remains a complex task. Efforts are being made to modify well-known CPPs in order to overcome their limitations and enhance their internalization capabilities and penetration mechanisms.

PHARMACEUTICS (2022)

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Endocytosis-Independent and Cancer-Selective Cytosolic Protein Delivery via Reversible Tagging with LAT1 substrate

Ziyin Zhao et al.

Summary: This study reports a carrier-free approach for efficient delivery of protein drugs targeting intracellular machineries. By modifying proteins, they can bypass endocytosis and capture, and directly enter tumor cells. In the cytosol, overproduced H2O2 can also restore the structure and activity of the proteins. Using this method, various protein drugs can be efficiently delivered into tumor cells.

ADVANCED MATERIALS (2022)

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A Traceless Site-Specific Conjugation on Native Antibodies Enables Efficient One-Step Payload Assembly

Yue Zeng et al.

Summary: In this paper, a strategy for the facile and efficient one-step synthesis of site-specific antibody-drug conjugates (ADCs) using a thioester-based acyl transfer reagent is reported. This strategy allows for the selective modification of antibodies and demonstrates excellent homogeneity, stability, and anti-tumor activity.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Monoclonal antibody therapeutics for infectious diseases: Beyond normal human immunoglobulin

Ryota Otsubo et al.

Summary: Antibody therapy is effective for treating infectious diseases. The rapid development of neutralizing monoclonal antibodies (mAbs) is urgently needed due to the COVID-19 pandemic and the rise of drug-resistant bacteria. Three methods, including phage display, B cell receptor (BCR) cDNA sequencing, and antibody-encoding gene and amino acid sequencing, can be used to obtain naive human mAbs. However, only a few of these mAbs have been approved for therapy. Therefore, antigen characterization and evaluation of neutralization activity are crucial for the development of therapeutic mAbs.

PHARMACOLOGY & THERAPEUTICS (2022)

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Article Engineering, Biomedical

Approaches and materials for endocytosis-independent intracellular delivery of proteins

Nanxi Chen et al.

Summary: Intracellular delivery of proteins is crucial for disease treatment and genetic engineering. Existing delivery strategies are inefficient, but endocytosis-independent intracellular delivery can improve efficiency and create new delivery pathways.

BIOMATERIALS (2022)

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Designing antibodies as therapeutics

Paul J. Carter et al.

Summary: Antibody therapeutics have significant health benefits and are rapidly expanding. This article provides an overview of current antibody therapeutics, including formats, targets, therapeutic areas, and administration routes. It also highlights emerging directions in antibody design, such as enhancing antibodies for cancer treatment and delivering antibodies to specific organs. In addition, the challenges of antibody developability and the potential of machine learning in antibody discovery are discussed.

CELL (2022)

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Chemical and Enzymatic Methods for Post-Translational Protein-Protein Conjugation

Ross J. Taylor et al.

Summary: This article focuses on the progress of chemical and enzymatic approaches in generating protein-protein conjugates through post-translational processes. Various methods and their applications are discussed, highlighting the successes and challenges of these approaches, as well as future directions for further development.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Room-Temperature Grafting from Synthesis of Protein-Polydisulfide Conjugates via Aggregation-Induced Polymerization

Jianhua Lu et al.

Summary: The protein-mediated, aggregation-induced polymerization of amphiphilic LPA-derived monomers at room temperature enables low concentration PDS conjugation and enhances protein stability and resistance to enzymatic activity and freeze-thaw treatments. It also allows rapid purification of Cys-bearing proteins and opens up new possibilities for protein delivery, reversible protein engineering, enzyme preservation, and recycling.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Mechanistic insights into the rational design of masked antibodies

Carolina T. Orozco et al.

Summary: This study investigated the mechanism of designing ideal affinity-based masks for antibodies. By using different masks with various properties, the researchers identified four critical factors and validated the binding sites on the antibody using HDX-MS and crystal structure analysis.

MABS (2022)

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Avidity in antibody effector functions and biotherapeutic drug design

Simone C. Oostindie et al.

Summary: This review discusses the role of avidity in eliciting antibody functional responses and current engineering strategies for manipulating avidity interactions in antibody-based therapies. Avidity, derived from multiple affinity interactions, is fundamental to all aspects of antibody biology and is crucial for enhancing or engineering novel properties in antibody biotherapeutics. Therapeutic antibody mechanisms of action are comprehensively reviewed with an emphasis on engineered optimizations and platforms, leading to a new wave of differentiated antibody drugs with tailored properties and promising improved treatment options for various diseases.

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Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance

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Summary: Researchers have developed a structure-guided and phage-assisted evolution approach to reverse cetuximab resistance mediated by EGFR mutations, without altering the binding epitope or undermining antibody efficacy.

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Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes

Dingdong Yuan et al.

Summary: This study reports a peptide-guided, proximity-driven group transfer reaction for site-selective acetylation of a single lysine residue in IgG. The reaction proceeded efficiently under physiological conditions without the need for deglycosylation or catalysts, allowing further derivatization of IgG. The method was also used to synthesize antibody-lipid conjugates and antibody-conjugated liposomes for targeted cancer cell therapy. Additionally, a bispecific antibody complex showed potent in vitro cytotoxicity at nanomolar concentrations.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Multidisciplinary Sciences

Antibody targeting of E3 ubiquitin ligases for receptor degradation

Hadir Marei et al.

Summary: The study presents a strategy utilizing PROTABs technology to achieve target degradation advantages, enabling tissue-selective degradation of cell-surface receptors. By optimizing antibody formats, this technology can facilitate 'on-demand' degradation.

NATURE (2022)

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Review Chemistry, Multidisciplinary

Non-internalising antibody-drug conjugates

Nicola Ashman et al.

Summary: Traditional antibody-drug conjugates (ADCs) require internalisation into cancer cells, but this approach has limitations. Recent research has shown that extracellular release of drugs upon binding to poorly-internalising antigens or other tumoral components can overcome these limitations. This new approach has the potential to expand the range of cancer targets and improve treatment efficacy.

CHEMICAL SOCIETY REVIEWS (2022)

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Article Chemistry, Multidisciplinary

A pH-responsive crosslinker platform for antibody-drug conjugate (ADC) targeting delivery

Francesca Migliorini et al.

Summary: A new self-immolative, traceless crosslinker derived from the natural product gallic acid was reported. The linker releases drug molecules through a pH-dependent mechanism, with release occurring at pH 5.5. The linker is non-toxic and enhances the cytotoxicity of anticancer drugs.

CHEMICAL COMMUNICATIONS (2022)

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Article Chemistry, Multidisciplinary

Intra Q-body: an antibody-based fluorogenic probe for intracellular proteins that allows live cell imaging and sorting

Yancen Dai et al.

Summary: This study developed a conditionally active Q-body probe for precise imaging of intracellular p53 in living cells with low background signal. The Q-body showed significant fluorescence enhancement in vitro and in both fixed and live cells. Live-cell sorting based on p53 expression was also demonstrated.

CHEMICAL SCIENCE (2022)

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Article Multidisciplinary Sciences

Promoting antibody-dependent cellular phagocytosis for effective macrophage-based cancer immunotherapy

Xu Cao et al.

Summary: This study identifies paclitaxel as a universal adjuvant that enhances the efficacy of antibody-dependent cellular phagocytosis (ADCP) in multiple cancers. The researchers found that paclitaxel polarizes macrophages and enhances their phagocytic ability, leading to increased ADCP of cancer cells. Furthermore, the down-regulation of CSF1R in macrophages enhances the ADCP of cancer cells. These findings suggest a potent strategy for using conventional anticancer drugs to stimulate macrophage phagocytosis and enhance the therapeutic efficacy of clinical anticancer antibodies.

SCIENCE ADVANCES (2022)

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Article Biotechnology & Applied Microbiology

Soluble Papain to Digest Monoclonal Antibodies; Time and Cost-Effective Method to Obtain Fab Fragment

Matthew Collins et al.

Summary: In this study, a time and cost-effective method using soluble papain to produce pure and active Fabs was proposed. Large scale digestion of an antibody resulted in Fabs with similar binding activity compared to traditional methods. The conjugation of Fabs and PEG produced antibody mimetics with good binding activity towards the intended antigen.

BIOENGINEERING-BASEL (2022)

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Article Chemistry, Multidisciplinary

A proximity labeling method for protein-protein interactions on cell membrane

Qiongyu Li et al.

Summary: Antigen-antibody proximity labeling (AAPL) is a novel method to map the antigen interaction sites as well as interactors of antibody-targeted proteins. Oxidative proteomic analysis can determine the degree of oxidation, the site of oxidation within the targeted antigen, and the interacting proteins that were in close proximity to the targeted antigen.

CHEMICAL SCIENCE (2022)

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Article Chemistry, Multidisciplinary

A photoresponsive antibody-siRNA conjugate for activatable immunogene therapy of cancer

Xingxing Wang et al.

Summary: This study presents a photoresponsive antibody-siRNA conjugate (PARC) for tumor-specific and photoinducible siRNA delivery and activatable cancer immunogene therapy. PARC targets cancer cells through the interaction between the antibody and membrane antigen, and releases siRNA upon light irradiation. The released siRNA degrades intracellular mRNA and blocks the membrane antigen to enhance immune cell activity. PARC shows effective cancer suppression in vitro and in vivo.

CHEMICAL SCIENCE (2022)

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Review Biochemistry & Molecular Biology

Targeted protein degradation: mechanisms, strategies and application

Lin Zhao et al.

Summary: Traditional drug discovery focuses on direct regulation of protein activity. However, the emerging targeted protein degradation (TPD) technologies, such as PROTAC, provide potential approaches to remove disease-associated proteins by utilizing cells' degradation machinery. These TPD strategies, including molecular glue, LYTAC, and AbTAC, expand the scope of TPD and offer fresh insights into drug discovery.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Biochemistry & Molecular Biology

Antibody drug conjugate: the biological missile for targeted cancer therapy

Zhiwen Fu et al.

Summary: Antibody-drug conjugates (ADCs) combine the highly specific targeting ability of monoclonal antibodies with the potent killing effect of cytotoxic drugs to accurately and efficiently eliminate cancer cells. Since the approval of the first ADC in 2000, 14 ADCs have been marketed worldwide, with over 100 ADC candidates currently in clinical trials. These novel cancer therapeutics, known as biological missiles, are leading the way in targeted cancer therapy.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Immunology

Review Article Development of Bispecific Antibody for Cancer Immunotherapy: Focus on T Cell Engaging Antibody

Dain Moon et al.

Summary: In the era of immunotherapeutic control of cancers, advances in biotechnology, especially in Ab engineering, have provided new candidates for therapeutic immunooncology. Among them, TCEBs that target both T cells and tumor cells through tumor cell specific antigens are the most promising BsAbs. The development of TCEBs and their diverse formats, characteristics, and functional mechanisms are discussed, including the challenges and drawbacks associated with current TCEB therapy.

IMMUNE NETWORK (2022)

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Review Biochemistry & Molecular Biology

Emerging new therapeutic antibody derivatives for cancer treatment

Shijie Jin et al.

Summary: This review article introduces the potential of monoclonal antibodies as targeted anticancer agents and their applications in cancer therapy. It also discusses various types of antibodies, clinical study advances, and the rationale and mechanisms of different antibody formats. Well-designed novel antibodies are paving the way for successful treatments of various cancers in the clinic.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Chemistry, Multidisciplinary

Smart Design of Nanomaterials for Mitochondria-Targeted Nanotherapeutics

Si Si Liew et al.

Summary: This review summarizes recent developments and strategies in the smart design of nanocarriers for mitochondria-targeted therapeutics, including subcellular targeting, stimuli-responsive nanocarriers, and synergistic therapy, while also discussing existing challenges and unexplored therapeutic opportunities.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting

Mahmoud Labib et al.

Summary: Researchers have developed a method for tracking the expression of therapeutic protein targets in circulating tumour cells at the single-cell level using antibody-mediated magnetic labelling and microfluidic sorting. This approach allows for the direct identification of mutated proteins in CTCs and prediction of treatment response in mice with drug-susceptible and drug-resistant tumour xenografts.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Oncology

Nanobodies: The Future of Antibody-Based Immune Therapeutics

Nuthan Bathula et al.

Summary: Targeted therapy is an important treatment strategy to reduce damage to healthy tissues, particularly in cancer treatment. Antibodies play a crucial role in treating autoimmune conditions and blood-borne cancers, but face limitations in treating solid tumors. Nanobodies, emerging as an alternative therapeutic agent, have advantages such as small size, high stability, enhanced tissue penetration, and specificity, making them promising next-generation therapeutics.

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2021)

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Article

Strategies and Applications of Antigen-Binding Fragment (Fab) Production in Escherichia coli

Hui Chen et al.

Pharmaceutical Fronts (2021)

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Article Chemistry, Multidisciplinary

Hierarchical Self-assembly of Discrete Metal-Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery

Ji Liu et al.

Summary: The hierarchical self-assembly of metal-organic cages into supramolecular nanoparticles allows for efficient encapsulation of proteins for intracellular delivery and potential therapeutic applications, such as CRISPR/Cas9 genome editing.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Biotechnology & Applied Microbiology

Proximity ligation assay: an ultrasensitive method for protein quantification and its applications in pathogen detection

Pengzhi Wang et al.

Summary: This research summarizes the basic principles of proximity ligation assay (PLA) and its applications in pathogen detection, suggesting that as an ultrasensitive protein assay, PLA has great potential for quantification, localization of protein, and clinical diagnostics.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

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Article Biochemical Research Methods

Synthetic Tuning of Domain Stoichiometry in Nanobody-Enzyme Megamolecules

Kevin J. Metcalf et al.

Summary: This study presents a method to synthetically tune protein conjugates for improved cancer therapy. By utilizing a megamolecule approach, the researchers were able to increase cytotoxicity effects on cancer cells by modifying the domain stoichiometry of the conjugates. The results demonstrate that synthetic control of protein domain stoichiometry can enhance the structure-function relationships of protein conjugate therapeutics for cancer treatment.

BIOCONJUGATE CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Genetic and Covalent Protein Modification Strategies to Facilitate Intracellular Delivery

Justin M. Horn et al.

Summary: Protein-based therapeutics are a rapidly growing field in disease treatment, and successful intracellular delivery is crucial for expanding their applications. Various methods for modifying proteins and peptides have been developed to improve their cellular translocation efficiency. General strategies such as chemical supercharging or inclusion of cell-penetrating motifs can facilitate intracellular delivery of proteins.

BIOMACROMOLECULES (2021)

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Article Chemistry, Multidisciplinary

Design of Polymers for Intracellular Protein and Peptide Delivery

Yiyun Cheng

Summary: The research group focuses on developing polymeric carriers for cytosolic protein delivery, aiming to improve delivery efficiency and bioactivity by modifying polymer structures and introducing different functional groups. The experimental results show that these polymers exhibit excellent performance in delivering tumor antigens, therapeutic peptides, and more in vivo, providing a new approach for future disease treatment.

CHINESE JOURNAL OF CHEMISTRY (2021)

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Review Biotechnology & Applied Microbiology

An overview of process development for antibody-drug conjugates produced by chemical conjugation technology

Yutaka Matsuda et al.

Summary: From an industrial perspective, this article discusses chemical conjugation strategies for ADCs and compares three promising technologies. The majority of commercially approved ADCs currently have relatively broad drug distributions, limiting their therapeutic indices. The industrial interest in the ADC field is shifting towards site-specific conjugation technologies.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

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Article Chemistry, Multidisciplinary

Engineered Cell-Penetrating Peptides for Mitochondrion-Targeted Drug Delivery in Cancer Therapy

Qicai Xiao et al.

Summary: Mitochondrion is a promising target for cancer therapy, and cell-penetrating peptides with mitochondrion-targeting ability are efficient tools for delivering therapeutics. New mitochondrion-targeting peptides (MTPs) have been synthesized, with MTP3 showing excellent mitochondrion-targeting ability and potential for drug delivery. The study validated the feasibility of MTP3 by preparing a mitochondrion-targeting prodrug that showed good cytotoxicity against tumor cells while having minimal toxicity towards normal cells.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

Adam D. Cotton et al.

Summary: AbTACs are fully recombinant bispecific antibodies that recruit membrane-bound E3 ligases for the degradation of cell-surface proteins. This new archetype represents a method within the PROTAC field to target cell-surface proteins with fully recombinant biological molecules.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Review Biochemical Research Methods

Deciphering molecular interactions by proximity labeling

Wei Qin et al.

Summary: This article introduces the proximity labeling technology for studying and applying molecular interactions. By fusing baits with promiscuous enzymes, endogenous molecules interacting with them can be tagged and identified by mass spectrometry or nucleic acid sequencing. PL technology has been used to map protein-protein, protein-RNA, and protein-DNA interactions.

NATURE METHODS (2021)

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Review Nanoscience & Nanotechnology

Nanomaterials for T-cell cancer immunotherapy

Ningqiang Gong et al.

Summary: T-cell-based immunotherapies show promise in treating cancer, but face challenges such as insufficient expansion of transferred T cells and inefficient trafficking into tumors. Nanomaterials offer a solution to enhance T-cell therapy by overcoming physical barriers and modulating tumor microenvironments.

NATURE NANOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Paul-Albert Koenig et al.

Summary: In this study, new neutralizing nanobodies targeting the SARS-CoV-2 spike protein were developed, showing enhanced neutralizing activity through engineering technology and successfully suppressing the emergence of escape mutants. The findings suggest that nanobodies can neutralize through receptor binding competition and also render virions noninfectious.

SCIENCE (2021)

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Review Pharmacology & Pharmacy

Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation

Harini Narayanan et al.

Summary: Successful biologics must meet requirements of both activity and physicochemical features, which can be optimized with the help of artificial intelligence and machine learning to reduce development time and costs. Machine learning is currently applied in biologics discovery and development, particularly in areas such as protein engineering, early biophysical screening, and formulation.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations

Malgorzata Kus-Liskiewicz et al.

Summary: This review discusses the potential applications of metal nanoparticles, particularly gold nanoparticles, in various fields, and how their characteristics can affect biological activity. It introduces methods for evaluating cytotoxicity and biocompatibility, and addresses the impact of the lack of reliable, universal safety regulations on the development of these applications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States

Shuhui Lim et al.

Summary: Mutations in RAS proteins are common drivers of cancer, with some mutations being particularly difficult to treat. Targeted degradation has emerged as a promising alternative approach, but challenges remain in finding high-affinity ligands for KRAS and in discovering hybrid molecules that can effectively degrade the protein.

ACS CENTRAL SCIENCE (2021)

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Article Oncology

Preclinical PET imaging with the novel human antibody 89Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues

Marcus P. Kelly et al.

Summary: This study successfully utilized zirconium-89 labeling to image human tumor xenografts using the anti-PD-L1 antibody REGN3504, showing accurate localization and biodistribution. The results suggest potential clinical translation of Zr-89-REGN3504 immuno-PET for assessing PD-L1 expression and monitoring response to anti-PD-1 therapy. Radiation dosimetry indicated safe absorbed doses within guidelines for other clinically used radiolabeled antibodies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Chemistry, Multidisciplinary

The renaissance of chemically generated bispecific antibodies

Peter Szijj et al.

Summary: Bispecific antibodies are a new class of biologics that target two different epitopes. While traditionally produced through protein engineering, recent advances in chemical methods have shown potential to compete with, and even surpass, protein engineering techniques by offering modularity, reproducibility, and ease of attaching additional cargo molecules. These innovative approaches have the potential to revolutionize the field by allowing for rapid generation of new formats and easy variation in antibody linker and construction.

NATURE REVIEWS CHEMISTRY (2021)

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Review Nanoscience & Nanotechnology

Metal-Organic Frameworks for Drug Delivery: A Design Perspective

Harrison D. Lawson et al.

Summary: The use of metal-organic frameworks (MOFs) in biomedical applications has greatly expanded in the past decade due to their precision tunability, high surface areas, and high loading capacities. MOFs are being explored for a wide variety of drug delivery applications, including small-molecule pharmaceuticals as well as macromolecular cargos like proteins and nucleic acids. Design considerations for MOFs in drug delivery applications include structure, synthetic method, drug loading, tuning, modifications, biocompatibility, cellular targeting, and uptake.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Recent Advances in Polymeric Nanoparticles for Enhanced Fluorescence and Photoacoustic Imaging

Sing Yee Ong et al.

Summary: This review discusses the recent advances in the use of polymeric nanoparticles for fluorescence and photoacoustic imaging, focusing on strategies for enhanced bioimaging applications such as encapsulating dyes and doping ions. Limitations in current systems are highlighted, along with potential solutions. Critical considerations for the design of polymeric NPs for future bioimaging and sensing applications are also discussed.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Oncology

Recent Achievements and Challenges in Prolonging the Serum Half-Lives of Therapeutic IgG Antibodies Through Fc Engineering

Sanghwan Ko et al.

Summary: The association and dissociation of FcRn molecules to the Fc region of IgG in acidified endosomes enables IgG molecules to be recycled for prolonged serum persistence. Exploiting this mechanism, researchers have engineered Fc variants to extend the serum half-lives of therapeutic antibodies. Multiple validated Fc variants have entered human clinical trials for various diseases.

BIODRUGS (2021)

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Review Engineering, Biomedical

Extracellular vesicles: A bright star of nanomedicine

Peipei Wu et al.

Summary: Extracellular vesicles play a crucial role in disease treatment and diagnosis, with engineered design enhancing their therapeutic capability and diagnostic imaging potential.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Targeted Fluorogenic Cyanine Carbamates Enable In Vivo Analysis of Antibody-Drug Conjugate Linker Chemistry

Syed Muhammad Usama et al.

Summary: ADCs are an important therapeutic platform, where the linker between antibodies and drug payloads greatly affects efficacy and tolerability. A new NIR imaging method has been developed to quantitatively assess linker cleavage efficiency, enabled by an improved variant of the CyBam platform. Furthermore, different linkers were compared across antibodies and tumor models, revealing that cathepsin-cleavable linkers show higher tumor activation.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Chemistry, Multidisciplinary

Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation

Heng Zhang et al.

Summary: The study introduces a covalent nanobody-based PROTAC strategy named GlueTAC for targeted membrane protein degradation with high specificity and efficiency. By developing a mass-spectrometry-based screening platform, a covalent nanobody (GlueBody) was created for proximity-enabled cross-linking with surface antigens on cancer cells, leading to the internalization and degradation of PD-L1 by the resulting GlueTAC chimera.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Review Chemistry, Multidisciplinary

Design of Polymeric Carriers for Intracellular Peptide Delivery in Oncology Applications

Shixian Lv et al.

Summary: Peptides as promising cancer therapeutics have shown robust antitumor efficacy, but the translation into clinical therapies is hindered by inherent limitations in their structure, hindering intracellular delivery. Strategies to engineer polymeric materials for increased peptide delivery efficiency, especially cytosolic delivery, play a crucial role in potentiating peptide-based cancer therapies. Future opportunities for peptides in cancer treatment lie in the design of polymer nanocarriers for optimized peptide delivery.

CHEMICAL REVIEWS (2021)

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Article Neurosciences

ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease

Eva Nordstrom et al.

Summary: ABBV-0805 is a humanized monoclonal antibody with high selectivity for aggregated alpha-synuclein, demonstrating efficacy in cellular and animal models, and showing potential disease-modifying treatment for Parkinson's disease based on strong preclinical findings.

NEUROBIOLOGY OF DISEASE (2021)

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Article Chemistry, Medicinal

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties

Peter S. Dragovich et al.

Summary: This study explores the use of antibody-drug conjugates as delivery vehicles to improve the bioavailability and anticancer activity of proteolysis-targeting chimeras. Results demonstrate that these conjugates can have antigen-dependent effects on prostate cancer cells.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Fc-engineered antibodies with immune effector functions completely abolished

Ian Wilkinson et al.

Summary: Novel variants with specific amino acid substitutions at L234 and L235 combined with G236R substitution completely eliminate binding to Fc. receptors, avoiding inflammatory responses and improving the safety and efficacy of therapeutic antibodies and Fc fusion proteins.

PLOS ONE (2021)

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Review Oncology

Unlocking the potential of antibody-drug conjugates for cancer therapy

Joshua Z. Drago et al.

Summary: Nine ADCs are currently approved for cancer treatment, with many more in development. Advances in synthetic biochemistry have led to a new generation of ADCs promising improved tissue specificity and cytotoxicity. Despite impressive activity against treatment-refractory cancers, challenges such as systemic toxicity and acquired resistance remain. This review discusses the design, mechanism of action, and limitations of ADCs, proposing strategies to maximize their therapeutic benefit for cancer patients.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Target-induced clustering activates Trim-Away of pathogens and proteins

Jingwei Zeng et al.

Summary: The article explains the working principle of Trim-Away, a new technology that utilizes TRIM21's ubiquitination activity for protein degradation, promoting virus neutralization or targeting disease-causing proteins. The study expands the understanding of TRIM21 and broadens the application of Trim-Away.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

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Review Pharmacology & Pharmacy

Engineered antibody fusion proteins for targeted disease therapy

Aliyah B. Silver et al.

Summary: Since the approval of the first therapeutic antibody by FDA 35 years ago, antibody-based products have become increasingly important in the pharmaceutical market. Recent efforts have focused on genetically fusing antibodies to disease-relevant payloads, such as cytokines, toxins, enzymes, neuroprotective agents, and soluble factor traps, to enable targeted delivery of therapeutic payloads. With numerous antibody fusion proteins in clinical trials and new innovative molecules on the horizon, these potent and multifunctional drug candidates are expected to play a significant role in therapeutic development for years to come.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

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Review Chemistry, Multidisciplinary

Development of Polymeric Nanoparticles for Blood-Brain Barrier Transfer-Strategies and Challenges

Weisen Zhang et al.

Summary: Polymeric nanoparticles have shown great potential in overcoming the blood-brain barrier for effective drug delivery, with their unique properties offering high tunability and ease of synthesis. Careful analysis of their performance in transporting drugs across the blood-brain barrier is essential for successful drug delivery to the central nervous system.

ADVANCED SCIENCE (2021)

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Article Multidisciplinary Sciences

Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks

Maik Muller et al.

Summary: The spatial organization of cell surface receptors is critical for cell signaling and drug action. Here, the authors develop an optoproteomic method for mapping surface protein interactions, revealing cellular responses to antibodies, drugs and viral particles as well as immunosynapse signaling events.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins

Yaxian Zhou et al.

Summary: Targeted protein degradation (TPD) technology has become a focus of attention for researchers due to its potential as a new therapeutic modality and selective removal of various protein targets. Specifically, LYsosome TArgeting Chimera (LYTAC) has emerged as a promising technology for degrading extracellular protein targets, using the cation-independent mannose-6-phosphate receptor (CI-M6PR) to deliver them to lysosomes. This study successfully utilized the asialoglycoprotein receptor (ASGPR) expressed on liver cells, with the ligand triantennary N-acetylgalactosamine (tri-GalNAc), to target extracellular proteins for degradation, demonstrating cell type specificity in liver cell lines.

ACS CENTRAL SCIENCE (2021)

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Article Multidisciplinary Sciences

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis

Capucine L. Grandjean et al.

Summary: It was found that macrophages in the bone marrow are the main way to eliminate tumors, but they can only act on neighboring tumors and have a limited active time.

SCIENCE ADVANCES (2021)

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Review Medicine, General & Internal

Antibody-Oligonucleotide Conjugates: A Twist to Antibody-Drug Conjugates

Julien Dugal-Tessier et al.

Summary: This article summarizes the key technological advancements in the preparation of antibody-oligonucleotide conjugates (AOCs) and discusses the distinct advantages and disadvantages of AOCs as novel therapeutics. It evaluates the merits and demerits of different methods of conjugating oligonucleotides to antibodies, mainly focusing on AOC purification and analytical characterizations. Lessons learned from in vitro and in vivo studies, particularly findings related to silencing, trafficking, and cytotoxicity of the conjugates, are also summarized.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Nanogel-Facilitated Protein Intracellular Specific Degradation through Trim-Away

Binglin Sui et al.

Summary: The Nano-ERASER technique, utilizing an antibody-conjugated polymer nanogel system, facilitates targeted intracellular delivery, release, and degradation of specific endogenous proteins, showing promising efficacy and convenience in studying protein function and potentially serving as a novel therapeutic modality for cancer and other diseases.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Biotechnology & Applied Microbiology

Vaccinal antibodies: Fc antibody engineering to improve the antiviral antibody response and induce vaccine-like effects

Dhuha H. Nawab

Summary: The COVID-19 pandemic underscores the urgent need for efficient virus therapies and vaccines. Improvements in antibody-based therapeutics are necessary, with engineered IgG Fc domain producing antibodies that can meet clinical demands. Fc receptors play crucial roles in linking innate and adaptive immunity against viral threats, and new engineering strategies aim to enhance the safety and efficacy of human antiviral antibodies and vaccines.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Article Chemistry, Multidisciplinary

Oligonucleotide Bioconjugation with Bifunctional Palladium Reagents

Muhammad Jbara et al.

Summary: Organometallic reagents have enabled practical strategies for bioconjugation in water, with a focus on peptides, proteins, and oligonucleotides. The development of bifunctional palladium(II)-oxidative addition complexes allows for high-yielding and chemoselective oligonucleotide bioconjugation reactions, even with a broad range of native thiol-containing biomolecules at low micromolar concentrations. This approach provides a versatile method for creating various oligonucleotide conjugates with other biomolecules, such as peptides, proteins, and small molecules, and allows for the conjugation of multiple copies of oligonucleotides onto a monoclonal antibody.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Medicine, Research & Experimental

Approval success rates of drug candidates based on target, action, modality, application, and their combinations

Shingo Yamaguchi et al.

Summary: The study revealed that the approval success rate of drug candidates is influenced by drug features, with specific types of drugs having higher success rates in terms of drug action and drug modality. Stimulant in drug action, and drug application categories B, G, or J were statistically associated with higher approval success rates.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2021)

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Review Pharmacology & Pharmacy

Current and Emerging Strategies for Enhancing Antibody Delivery to the Brain

Rinie Bajracharya et al.

Summary: Achieving sufficient exposure to the brain parenchyma is crucial for the treatment of neurological diseases, but the blood-brain barrier poses a major obstacle for drug efficacy. Current strategies to enhance antibody delivery across the BBB include focused ultrasound with microbubbles, engineered bi-specific antibodies, and nanoparticles.

PHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

A Promising Intracellular Protein-Degradation Strategy: TRIMbody-Away Technique Based on Nanobody Fragment

Gang Chen et al.

Summary: TRIM-Away technology enables rapid degradation of endogenous target proteins using specific antibodies and TRIM21. By replacing full-size mAbs with nanobodies, researchers created TRIMbody fusion proteins and successfully achieved specific degradation of intracellular EGFP.

BIOMOLECULES (2021)

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Article Chemistry, Medicinal

Targeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug Discovery

Junping Pei et al.

Summary: This article discusses strategies targeting lysosomal pathways and lysosome-based degradation techniques, as well as the advantages and challenges of lysosome-based degrading drugs. These tools can directly regulate protein levels in vivo and provide new strategies for treating diseases.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen

Keita Nakane et al.

Summary: A new strategy for histidine functionalization using an umpolung approach under singlet oxygen generation conditions was reported. This rapid labeling method could be applied for instant protein labeling and proximity labeling on the nanometer scale using the short diffusion distance of singlet oxygen.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Biochemistry & Molecular Biology

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

Green Ahn et al.

Summary: Selective protein degradation platforms such as LYTACs provide new opportunities for therapeutic development and biological research. By targeting specific lysosome receptors in a cell-type-specific manner, these LYTACs can efficiently degrade extracellular proteins and hold promise for cell-type-restricted protein degradation strategies.

NATURE CHEMICAL BIOLOGY (2021)

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News Item Biotechnology & Applied Microbiology

FDA approves 100th monoclonal antibody product

Asher Mullard

Summary: After 35 years since the FDA approved the first monoclonal antibody, these biologics now make up nearly one fifth of the agency's new drug approvals each year.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Multidisciplinary Sciences

Selective and noncovalent targeting of RAS mutants for inhibition and degradation

Kai Wen Teng et al.

Summary: A monobody named 12VC1 that can selectively recognize and bind to the active state of KRAS mutants has been discovered in this study, showing great potential in inhibiting the proliferation of RAS-driven cancer cell lines. This finding suggests a new strategy for treating oncogenic RAS mutants through inhibition and degradation.

NATURE COMMUNICATIONS (2021)

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Review Engineering, Biomedical

Biomaterials-Based Delivery of Therapeutic Antibodies for Cancer Therapy

Qian-Ni Ye et al.

Summary: Considerable breakthroughs have been made in the treatment of malignant tumors using antibody drugs, but challenges such as instability in vivo, poor tumor penetration, and limited response rate remain. Biomaterials-based delivery systems have been reported to enhance the efficacy of antibody drugs in recent years. The integration of biomaterials with therapeutic antibodies shows promise in enhancing cancer therapy.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Immunology

Bispecific Antibodies: From Research to Clinical Application

Jiabing Ma et al.

Summary: Bispecific antibodies (BsAbs) have two binding sites directed at different antigens or epitopes, and their clinical therapeutic effects are superior to monoclonal antibodies (MoAbs), used in tumor immunotherapy and other disease treatments. Over 30 mature commercial technology platforms have been utilized to generate and develop BsAbs based on heterologous recombination of heavy chains and light chains, with three BsAbs receiving market approval.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary

The Masking Game: Design of Activatable Antibodies and Mimetics for Selective Therapeutics and Cell Control

Roberta Lucchi et al.

Summary: Antibodies with high selectivity and affinity are widely used in therapy, diagnosis, and basic science. Chemogenetic approaches have enabled antibodies to respond to a variety of stimuli, leading to the development of new tools and therapeutics. Opportunities for further advancement exist in the development of more efficient masking strategies at the interface between chemistry and biotechnology.

ACS CENTRAL SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Unleashing the Power of Bond Cleavage Chemistry in Living Systems

Jie Wang et al.

Summary: Bioorthogonal cleavage chemistry, as a powerful tool for manipulation and gain-of-function studies of biomolecules, has opened up new possibilities for rescuing small molecules and biomacromolecules, allowing multidimensional control over biological processes.

ACS CENTRAL SCIENCE (2021)

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Review Pharmacology & Pharmacy

Antibody-drug conjugates: Recent advances in linker chemistry

Zheng Su et al.

Summary: ADCs are gradually revolutionizing clinical cancer therapy, and the linker molecule plays a crucial role in determining their efficacy and safety. An ideal linker should release the cytotoxic payload specifically in the tumor to avoid off-target toxicity. Recent research progress in novel linkers for ADCs has been significant, aiming to improve therapeutic outcomes and minimize adverse effects.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Chemistry, Multidisciplinary

Interrogating biological systems using visible-light-powered catalysis

Keun Ah Ryu et al.

Summary: Light-powered catalysis has been widely used as a chemical transformation strategy with significant impact on energy, environment, drug discovery, and human health. Research has shown the application of light-induced sensitization for photodynamic therapy in cancer treatment, inspiring exploration of other photochemical methods for influencing biological discovery. Additionally, advancements have been made in utilizing photosensitization and photoredox catalysis for therapeutic applications and probing complex cellular environments in living cells.

NATURE REVIEWS CHEMISTRY (2021)

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Review Chemistry, Medicinal

The Chemistry Behind ADCs

Vesela Kostova et al.

Summary: ADC has emerged as an efficient therapeutic approach for various cancers, combining the selective targeting of tumor cells through antigen-directed recognition and potent cell-killing by cytotoxic payloads. The selection of appropriate antibody and drug payload is dictated by the pharmacology of the targeted disease, while there is more flexibility in choosing the conjugating linker. This paper reviews the chemistry of ADCs, focusing on methods that enable the efficient assembly of ADC from its three components and the controlled release of the drug payload.

PHARMACEUTICALS (2021)

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Review Chemistry, Multidisciplinary

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

Bing-Mae Chen et al.

Summary: The article discusses the application of polyethylene glycol (PEG) in drugs and nanoparticles, as well as the potential immunogenicity issues it may cause. Research reveals rules for predicting rapid clearance of drugs and liposomes, and experimental studies on anti-PEG antibody binding to different forms and sizes of PEG are provided.

ACS NANO (2021)

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Review Chemistry, Multidisciplinary

Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Rumiana Tenchov et al.

Summary: Lipid nanoparticles (LNPs) have become promising vehicles in the pharmaceutical industry for delivering various therapeutics, particularly highlighted in the COVID-19 mRNA vaccines. LNPs exhibit versatility and physical stability, allowing for targeted delivery of therapeutic drugs to specific locations within the body. Liposomes, an early version of LNPs, have already been widely applied in medical practice.

ACS NANO (2021)

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Review Chemistry, Multidisciplinary

Mito-Bomb: Targeting Mitochondria for Cancer Therapy

Xiaolu Guo et al.

Summary: Traditional cancer therapies such as surgery, chemotherapy, and radiotherapy have limited effectiveness, while photodynamic therapy, photothermal therapy, and chemodynamic therapy have shown promising results in cancer treatment due to their high selectivity, minimal resistance, and minimal toxicity.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A Wireframe DNA Cube: Antibody Conjugate for Targeted Delivery of Multiple Copies of Monomethyl Auristatin E

Anders Marcher et al.

Summary: An antibody DNA wireframe cube conjugate has been developed for precise control of the drug-to-antibody ratio (DAR) in ADCs for cancer treatment. This method utilizes DNA functionalization to tightly control DAR, with gel electrophoresis and atomic force microscopy used for investigation, and successful application in targeted drug delivery in vitro.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides

Takahiro Iwata et al.

Summary: The Fc region binding peptide can assist in delivering immunoglobulin G into cells, forming particle-like liquid droplets; upon contact with the cellular membrane, the droplets spontaneously enter cells and distribute throughout; translocation of IgG is achieved through involvement of cellular machinery and membrane ruffling.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides

Juraj Konc et al.

Summary: A new bioconjugation platform has been developed for the preparation of DNA-antibody bioconjugates using a simple reagent, resulting in improved homogeneity of the prepared conjugates suitable for fluorescence or super-resolution microscopy cell imaging experiments.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

1,3-Diketone-Modified Nucleotides and DNA for Cross-Linking with Arginine-Containing Peptides and Proteins

Denise-Liu' Leone et al.

Summary: In this study, linear or branched 1,3-diketone-linked thymidine 5'-O-mono- and triphosphate were synthesized through CuAAC click reaction. The HDO modification in DNA was found to efficiently react with arginine-containing peptides to form stable conjugates, while the PDO group was not reactive. This reactive HDO modification in DNA was used for bioconjugations and cross-linking with Arg-containing peptides or proteins.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article

Generation of bispecific antibodies using chemical conjugation methods

Nazzareno Dimasi et al.

Drug Discovery Today: Technologies (2021)

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Review Biochemical Research Methods

Affinity-Based Methods for Site-Specific Conjugation of Antibodies

Emma von Witting et al.

Summary: Conjugating various reagents to antibodies has been proven to be an effective way to create homogeneous products with predictable characteristics for applications in new drug creation and analytical detection, among others. Researchers have developed novel methods and techniques for site-specific conjugation of antibodies based on small molecules, peptides, and proteins with inherent affinity for the antibody.

BIOCONJUGATE CHEMISTRY (2021)

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Review Cell Biology

Types of nuclear localization signals and mechanisms of protein import into the nucleus

Juane Lu et al.

Summary: This article summarizes the types of nuclear localization signals, focuses on recently reported proteins containing such signals, and briefly outlines mechanisms for nuclear entry that do not rely on nuclear localization signals.

CELL COMMUNICATION AND SIGNALING (2021)

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Article Chemistry, Multidisciplinary

Cell-Penetrating Mitochondrion-Targeting Ligands for the Universal Delivery of Small Molecules, Proteins and Nanomaterials

Qicai Xiao et al.

Summary: Two new cell-penetrating, mitochondrion-targeting ligands (named Mito(Ligand)) capable of effectively tagging small-molecule drugs, native proteins, and nanomaterials have been discovered. These ligands have corresponding chemoselective conjugation chemistry and, upon successful cellular delivery, released native cargos were predominantly localized inside mitochondria. Delivery of doxorubicin to mitochondria resulted in potent cell cytotoxicity, disruption of mitochondrial membrane potential, and ultimately apoptosis, paving the way for future mitochondrion-targeted therapy.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Principles and Current Clinical Landscape of Multispecific Antibodies against Cancer

Mariam Elshiaty et al.

Summary: The field of multispecific therapeutic antibodies is growing rapidly, with over 140 different molecules currently in clinical testing and excellent results in recent clinical trials. Strategies for enhancing anticancer efficacy are focused on disrupting multiple surface antigens and redirecting cytotoxic lymphocytes, with a trend towards more target antigens and increased valency in newer constructs. Exciting prospects include targeting intracellular neoantigens using T-cell receptor fusion proteins or TCR-mimic antibody fragments, offering hope for cure of advanced cancers in the near future.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Exploiting Protein N-Terminus for Site-Specific Bioconjugation

Lucia De Rosa et al.

Summary: This article provides an updated overview of methodologies developed to selectively modify proteins by targeting the N-terminal alpha-amine group. Chemical and enzymatic strategies for selective labeling of the protein N-terminal alpha-amine group are described.

MOLECULES (2021)

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Article Chemistry, Multidisciplinary

Cytosolic Protein Delivery for Intracellular Antigen Targeting Using Supercharged Polypeptide Delivery Platform

Qun Wang et al.

Summary: The study presents a novel and efficient intracellular protein delivery platform, capable of delivering proteins directly into the cytosol of living cells with high efficacy and safety. This system offers new possibilities for targeting intracellular undruggable targets and expanding the use of protein-based therapeutics, especially for antibodies.

NANO LETTERS (2021)

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Article Nanoscience & Nanotechnology

An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin

Elena Rosini et al.

Summary: A chimeric protein, F8(scFv)-DAAO-Q144R, was designed to target the EDA of fibronectin on tumor neovasculature. This recombinant protein showed high solubility, specific activity, and thermostability, with strong cytotoxicity to tumor cells. The conjugate has potential for selective antitumor oxidative therapy and minimal damage to normal tissues.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

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Article Multidisciplinary Sciences

Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy

Rachel Yamin et al.

Summary: Monoclonal antibodies with optimized Fc domains show superior potency in preventing and treating COVID-19 in animal disease models, reducing the dose required for protection against SARS-CoV-2 challenge and for treating pre-infected animals. Selective engagement of activating Fc receptors results in improved efficacy, highlighting the importance of Fc receptor pathways in driving antibody-mediated antiviral immunity. These findings have implications for the development of Fc-engineered monoclonal antibodies with optimal Fc-effector function against COVID-19.

NATURE (2021)

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Article Chemistry, Multidisciplinary

Switching on prodrugs using radiotherapy

Jin Geng et al.

Summary: The article introduces a chemistry-based strategy for simultaneous chemo-radiotherapy by activating cancer prodrugs through irradiation, enabling site-directed chemotherapy instead of systemic chemotherapy, which opens up a new era in targeted and directed chemotherapy.

NATURE CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool

Muhammad Imran Sajid et al.

Summary: Cyclic cell-penetrating peptides (CPPs) have great potential in delivering therapeutics for treating various diseases, but face limitations. There are approximately 40 cyclic peptides-based therapeutics available, with one entering the market annually.

PEPTIDES (2021)

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Article Multidisciplinary Sciences

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

Chisato M. Yamazaki et al.

Summary: In this study, dual-drug ADCs show promising therapeutic potential for treating heterogeneous breast tumors with minimal toxicity and optimal pharmacokinetic profiles. Compared to co-administration of two single-drug variants, the dual-drug ADC exhibits greater treatment effect and survival benefit in xenograft mouse models representing intratumor HER2 heterogeneity and drug resistance.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Protease-Activation of Fc-Masked Therapeutic Antibodies to Alleviate Off-Tumor Cytotoxicity

Adrian Elter et al.

Summary: This study introduces a novel Fc-tamed antibody format, which reduces off-target toxicity by blocking the Fc gamma R-binding sites of antibodies, resulting in decreased activation and improved safety profiles.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Rational Design of Poly(disulfide)s as a Universal Platform for Delivery of CRISPR-Cas9 Machineries toward Therapeutic Genome Editing

Jiajing Guo et al.

Summary: Poly(disulfide)s synthesized by ring-opening polymerization demonstrated excellent delivery performance for CRISPR-Cas9-based genome editors, including plasmid, mRNA, and protein. Their ability stems from molecular structures interacting with biomacromolecules, unique delivery pathways mediating cellular uptake, and strong ability to escape the endosome. Degradation by intracellular glutathione promotes timely release of CRISPR-Cas9 machinery and reduces cytotoxicity.

ACS CENTRAL SCIENCE (2021)

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Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

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Article Multidisciplinary Sciences

Switchable immune modulator for tumor-specific activation of anticancer immunity

Yu Zhao et al.

Summary: Sw-IM is a chemical approach to limit systemic toxicity of immune stimulatory antibodies and cytokines by selectively masking and activating them in response to tumor-specific stimuli, thus enhancing the safety and efficacy of antitumor immunotherapies.

SCIENCE ADVANCES (2021)

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Review Immunology

Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies

Gihoon You et al.

Summary: BsAbs are emerging as a growing class of immunotherapies with the potential to improve clinical efficacy and safety further. The review describes four classes of BsAbs and presents examples of BsAbs in development. With more data from clinical trials accumulating, BsAbs could be the next generation of new treatment options for cancer patients.

VACCINES (2021)

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Review Nanoscience & Nanotechnology

Recent electroporation-based systems for intracellular molecule delivery

Zaizai Dong et al.

Summary: Electroporation is an efficient method for intracellular molecule delivery, offering high efficiency and controlled dosage. Various electroporation technologies have emerged, including devices based on nanochannels, nanostraws, and microfluidic channels, which can be used for intracellular molecule delivery in different scenarios.

NANOTECHNOLOGY AND PRECISION ENGINEERING (2021)

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Article Chemistry, Multidisciplinary

A biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework for high-performance delivery of oral antibodies

Yuling Mao et al.

Summary: This study introduces a novel biomimetic nanocomposite for colon-targeted delivery of anti-TNF-alpha antibodies through the oral route, utilizing ginger-derived exosomes and an inorganic framework. The nanocomposite showed stability, colonic targeting, and high efficacy in inflammatory bowel disease therapy.

NANOSCALE (2021)

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Review Chemistry, Multidisciplinary

Recent developments in chemical conjugation strategies targeting native amino acids in proteins and their applications in antibody-drug conjugates

Min Sun Kang et al.

Summary: This article explores the need for effective bioconjugation methods in the fields of chemical biology and synthetic biology, with a focus on how novel organic synthesis can address issues with traditional linker technology. It also analyzes the current developments in modifying native amino acids on peptides or proteins for ADC linkers, and discusses the research efforts in constructing ADCs using different conjugation methods.

CHEMICAL SCIENCE (2021)

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Review Biochemistry & Molecular Biology

Development and application of therapeutic antibodies against COVID-19

Lin Ning et al.

Summary: The global health crisis caused by the COVID-19 pandemic continues, with many therapeutic antibody treatments in development and authorized for emergency use by the FDA. Ongoing clinical trials worldwide have shown therapeutic antibody therapies to be a crucial part of COVID-19 treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Chemistry, Multidisciplinary

Site-selective lysine conjugation methods and applications towards antibody-drug conjugates

Muhammed Haque et al.

Summary: Selective modification of lysine residues presents a significant challenge due to their popularity in bioconjugation. Antibody-drug conjugates heavily rely on lysine bioconjugation for synthesis, highlighting the importance of achieving site-selective lysine modification methodologies.

CHEMICAL COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Real-time imaging of cell-surface proteins with antibody-based fluorogenic probes

Wenchao Wang et al.

Summary: Cell-surface proteins play crucial roles in various diseases, and selectively detecting these proteins in real-time is essential for developing new drugs and medical diagnoses. An antibody-based fluorogenic probe, prepared through a two-step chemical modification under physiological conditions, allows for selective recognition and wash-free imaging of membrane proteins, offering a modular strategy with broad implications for biochemical research and therapeutics.

CHEMICAL SCIENCE (2021)

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Article Medicine, Research & Experimental

Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies

Maxwell A. Stefan et al.

Summary: The study identifies promising neutralizing humanized nanobody (VHH-huFc) antibodies using a synthetic, high-diversity VHH bacteriophage library, demonstrating their prophylactic and therapeutic effectiveness against wildtype SARS-CoV-2 in vivo. These antibodies represent viable candidates for further preclinical evaluation and for addressing the COVID-19 pandemic.

MABS (2021)

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Article Pharmacology & Pharmacy

Engineered Multivalent Nanobodies Potently and Broadly Neutralize SARS-CoV-2 Variants

Jennifer M. Zupancic et al.

Summary: A novel multivalent nanobody, VHH-72, has shown significant neutralizing activity against various SARS-CoV-2 variants with high biophysical stability, solubility, and specificity.

ADVANCED THERAPEUTICS (2021)

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Article Biochemistry & Molecular Biology

Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway

Green Ahn et al.

Summary: Targeted protein degradation (TPD) is a promising strategy to remove deleterious proteins for therapeutic benefit and to probe biological pathways. Various technologies have been developed to degrade challenging cytosolic targets, but there is a need for approaches to degrade extracellular and membrane proteins. Recent advancements in technology, such as lysosome-targeting chimeras (LYTACs), show potential in degrading both secreted and membrane-anchored targets.

CELL CHEMICAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Targeted protein degradation: A promise for undruggable proteins

Kusal T. G. Samarasinghe et al.

Summary: Protein homeostasis is crucial for maintaining a balanced, healthy environment within cells, but excessive dysregulated proteins can lead to disease. PROTACs and other Targeted Protein Degradation (TPD) strategies are emerging as potential therapeutic modalities for degrading disease-causing proteins, including previously undruggable targets like transcription factors.

CELL CHEMICAL BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Thiol-Mediated Uptake

Quentin Laurent et al.

Summary: This article mainly discusses the mechanism of thiol-mediated uptake, introducing the research progress and potential applications in this field.

JACS AU (2021)

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Article Multidisciplinary Sciences

Cell-free gene expression

David Garenne et al.

Summary: Cell-free gene expression (CFE) has emerged as an alternative approach for protein synthesis and labeling, and has been repurposed for synthetic biology and bioengineering. This Primer provides a comprehensive guide to best practices in CFE, focusing on Escherichia coli-based systems. The practical introduction to CFE showcases its versatility in producing proteins, manufacturing therapeutics, developing sensors, and prototyping genetic circuits, making it a powerful tool for biotechnology research.

NATURE REVIEWS METHODS PRIMERS (2021)

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Review Immunology

Recent Advances in the Molecular Design and Applications of Multispecific Biotherapeutics

Xiaotian Zhong et al.

Summary: Recombinant protein-based biotherapeutics drugs have revolutionized the clinical pipelines in the biopharmaceutical industry, with the emergence of multispecific biotherapeutics to address complex diseases through engaging multiple protein targets. These novel drugs offer the potential to tackle disease complexity, exploit new therapeutic mechanisms, and evaluate undruggable targets that conventional monospecific biologics cannot reach.

ANTIBODIES (2021)

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Review Biochemistry & Molecular Biology

Recent progress in targeted delivery vectors based on biomimetic nanoparticles

Li Chen et al.

Summary: Biomimetic nanoparticles (BNPs) integrate biological vectors with functional agents for targeted drug delivery. Natural vectors are deliberately modified to enhance permeability, loading capability, and specificity, making them more effective for delivering contrast agents, chemotherapy drugs, nucleic acids, and genes to target sites.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Lei Zhong et al.

Summary: Targeted therapeutic drugs have become mainstream cancer treatments due to their advantages in efficacy and safety, but still face challenges such as low response rate and drug resistance. A comprehensive review was conducted on small-molecule targeted anti-cancer drugs to promote their development, discussing current challenges and providing insights and perspectives for future research and development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Chemistry, Multidisciplinary

A dual-enzyme cleavable linker for antibody-drug conjugates

Jonathan D. Bargh et al.

Summary: A novel enzyme cleavable linker for antibody-drug conjugates, utilizing a highly hydrophilic dual-cleavable 3-O-sulfo-beta-galactose linker, shows excellent cytotoxicity and selectivity in targeted cells when used to synthesize an alpha-HER2 antibody-drug conjugate.

CHEMICAL COMMUNICATIONS (2021)

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Review Chemistry, Multidisciplinary

Stimulus-cleavable chemistry in the field of controlled drug delivery

Yufei Xue et al.

Summary: This review summarizes the recent advances in stimulus-cleavable linkers and their biological applications, highlighting the feasibility of extending their applications to various nanoscale drug carriers. It also provides general design guidelines for incorporating stimulus-cleavable linkers into nanocarrier-based drug delivery systems, aiming to spark new ideas and applications in this field.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Co-delivery of proteins and small molecule drugs for mitochondria-targeted combination therapy

Si Si Liew et al.

Summary: This study reports the first use of gluthathione-responsive nanogel-based carriers for mitochondria-targeted delivery of functional proteins and antibodies, as well as the successful co-encapsulation of a protein and small molecule (RNase A/Doxorubicin) in dual-cargo nanocapsules for mitochondria-targeted combination therapy.

CHEMICAL COMMUNICATIONS (2021)

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Review Immunology

Neutralizing monoclonal antibodies for treatment of COVID-19

Peter C. Taylor et al.

Summary: The study discusses the clinical utility of neutralizing monoclonal antibody therapies targeting SARS-CoV-2, emphasizing the importance of patient stratification, biomarkers, risk factors, and other clinical considerations.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Pharmacology & Pharmacy

Nanotechnologies for Intracellular Protein Delivery: Recent Progress in Inorganic and Organic Nanocarriers

Sarah Le Saux et al.

Summary: This article highlights the importance of proteins as drugs, discusses the significance of intracellular targeting therapy, explores the challenges faced by therapeutic proteins, and reviews the latest advancements in delivery system research.

ADVANCED THERAPEUTICS (2021)

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Article Medicine, Research & Experimental

Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in mice

Katerina T. Xenaki et al.

Summary: Extending the half-life of nanobodies through non-covalent interaction with albumin can enhance their accumulation in tumors and improve therapeutic efficacy.

THERANOSTICS (2021)

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Article Oncology

Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity

Shelley E. Ackerman et al.

Summary: Alonso and colleagues have developed immune-stimulating antibody conjugates that can specifically deliver TLR7/8 agonists to tumors, inducing durable antitumor immunity.

NATURE CANCER (2021)

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Review Chemistry, Analytical

Nucleic-Acid Driven Cooperative Bioassays Using Probe Proximity or Split-Probe Techniques

Andresa B. Bezerra et al.

ANALYTICAL CHEMISTRY (2021)

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Article Medicine, Research & Experimental

A general Fc engineering platform for the next generation of antibody therapeutics

Da Chen et al.

Summary: Fc engineering has become a focus in antibody drug development. A mammalian cell display-based platform was developed to screen millions of Fc variants for optimized binding to Fc gamma RIIIa or Fc gamma RIIb. Novel Fc variants with enhanced binding and improved effector function were successfully identified.

THERANOSTICS (2021)

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Review Medicine, Research & Experimental

The Current Landscape of Antibody-based Therapies in Solid Malignancies

Ashu Shah et al.

Summary: Monoclonal antibodies (mAbs) have revolutionized cancer therapy over the past three decades, but their efficacy remains limited by moderate response rates and resistance emergence. Resistance to mAbs is not only caused by tumor antigen heterogeneity, but also by the tumor microenvironment (TME) including inefficient delivery to the tumor, altered effector functions, and diversity in Fc-gamma receptor expression. Diagnostic and prognostic biomarkers play a crucial role in predicting response to mAb-based therapies.

THERANOSTICS (2021)

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Review Chemistry, Multidisciplinary

Macrophage-Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention

Xuefei Zhou et al.

Summary: Macrophages, important in tumor immunity, can engulf tumor cells and present antigens; tumor cells evade macrophage phagocytosis through anti-phagocytic molecules, while macrophages' efferocytosis of apoptotic cells promotes tumor immune escape; blocking anti-phagocytic signals or inhibiting tumor efferocytosis is a potential strategy for cancer immunotherapy.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Allergy

Complement System: a Neglected Pathway in Immunotherapy

Anne Bordron et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2020)

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Review Chemistry, Medicinal

Considerations for the Design of Antibody-Based Therapeutics

Dennis R. Goulet et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Review Oncology

Antibody therapeutics and immunoregulation in cancer and autoimmune disease

Masahiro Yasunaga

SEMINARS IN CANCER BIOLOGY (2020)

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Article Hematology

Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis

Kandace Gollomp et al.

BLOOD (2020)

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Article Chemistry, Medicinal

Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity

Thomas H. Pillow et al.

CHEMMEDCHEM (2020)

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Article Medicine, Research & Experimental

Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment

Traian Sulea et al.

MABS (2020)

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Review Oncology

Antibody-Drug Conjugates: A Comprehensive Review

Puregmaa Khongorzul et al.

MOLECULAR CANCER RESEARCH (2020)

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Article Chemistry, Multidisciplinary

DNA-Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing

Liqiang Pan et al.

ADVANCED SCIENCE (2020)

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Review Chemistry, Multidisciplinary

Nanoneedle Platforms: The Many Ways to Pierce the Cell Membrane

Gen He et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Aggregation-Induced Emission: New Vistas at the Aggregate Level

Zhao Zheng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

Photobodies: Light-Activatable Single-Domain Antibody Fragments

Benedikt Jedlitzke et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Biotechnology & Applied Microbiology

Antibody glycosylation: impact on antibody drug characteristics and quality control

Ziyan Wang et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

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Article Chemistry, Medicinal

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Peter S. Dragovich et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)

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Article Biotechnology & Applied Microbiology

Detection and destruction of HER2-positive cancer cells by Ultra Quenchbody-siRNA complex

Jinhua Dong et al.

BIOTECHNOLOGY AND BIOENGINEERING (2020)

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Article Hematology

Emicizumab, a humanized bispecific antibody to coagulation factors IXa and X with a factor VIIIa-cofactor activity

Takehisa Kitazawa et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2020)

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Review Pharmacology & Pharmacy

Recent progress in antitumor functions of the intracellular antibodies

Yunfeng Lin et al.

DRUG DISCOVERY TODAY (2020)

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Article Chemistry, Multidisciplinary

Competition-Based Universal Photonic Crystal Biosensors by Using Antibody-Antigen Interaction

Junjie Qin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

Cryopolymerization of 1,2-Dithiolanes for the Facile and Reversible Grafting-from Synthesis of Protein Polydisulfide Conjugates

Jianhua Lu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

Direct Cytosolic Delivery of Proteins through Coengineering of Proteins and Polymeric Delivery Vehicles

Yi-Wei Lee et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Biochemistry & Molecular Biology

A new anti-HER2 antibody that enhances the anti-tumor efficacy of trastuzumab and pertuzumab with a distinct mechanism of action

Xuesai Zhang et al.

MOLECULAR IMMUNOLOGY (2020)

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Article Oncology

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

John D. Martin et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Microenvironment mapping via Dexter energy transfer on immune cells

Jacob B. Geri et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones

Yingqian Zhang et al.

NATURE COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

Maria Maneiro et al.

ACS CHEMICAL BIOLOGY (2020)

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Review Chemistry, Multidisciplinary

Nanocarrier-Mediated Cytosolic Delivery of Biopharmaceuticals

Wei He et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Biochemical Research Methods

Recent progress in transglutaminase-mediated assembly of antibody-drug conjugates

Hendrik Schneider et al.

ANALYTICAL BIOCHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

Romain Tessier et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Biochemistry & Molecular Biology

Methods for protein delivery into cells: from current approaches to future perspectives

Chalmers Chau et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2020)

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Review Oncology

Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology

Congcong Zhang et al.

BIODRUGS (2020)

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Review Immunology

Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics

Heliang Li et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Review Chemistry, Multidisciplinary

ImmunoPET: Concept, Design, and Applications

Weijun Wei et al.

CHEMICAL REVIEWS (2020)

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Review Polymer Science

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Site-Specific Encoding of Photoactivity in Antibodies Enables Light-Mediated Antibody-Antigen Binding on Live Cells

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Copper-Triggered Bioorthogonal Cleavage Reactions for Reversible Protein and Cell Surface Modifications

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Computationally designed antibody-drug conjugates self-assembled via affinity ligands

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Esterification Delivers a Functional Enzyme into a Human Cell

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A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates (vol 10, 2019)

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Responsive Antibody Conjugates Enable Quantitative Determination of Intracellular Bond Degradation Rate

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Antibody-drug conjugates: recent advances in conjugation and linker chemistries

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Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity

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Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials

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Next generation antibody drugs: pursuit of the 'high-hanging fruit'

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Intracellular Delivery of Native Proteins Facilitated by Cell-Penetrating Poly(disulfide)s

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Nanobodies: Chemical Functionalization Strategies and Intracellular Applications

Dominik Schumacher et al.

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Emerging Methods and Design Principles for Cell-Penetrant Peptides

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Site-Specific Dual Labeling of Proteins on Cysteine Residues with Chlorotetrazines

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Nanoquencher-Based Selective Imaging of Protein Glutathionylation in Live Mammalian Cells

Xin Mao et al.

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Anti-Amyloid-β Monoclonal Antibodies for Alzheimer's Disease: Pitfalls and Promise

Christopher H. van Dyck

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Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation

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BMC CANCER (2018)

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Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation

Grace H. Pham et al.

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Single-site labeling of lysine in proteins through a metal-free multicomponent approach

Maheshwerreddy Chilamari et al.

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Protein delivery into cells using inorganic nanoparticle-protein supramolecular assemblies

Federica Scaletti et al.

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Advanced physical techniques for gene delivery based on membrane perforation

Xiaofan Du et al.

DRUG DELIVERY (2018)

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Functionalized extracellular vesicles as advanced therapeutic nanodelivery systems

Mei Lu et al.

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Glycosylated Cell-Penetrating Poly(disulfide)s: Multifunctional Cellular Uptake at High Solubility

Paola Morelli et al.

HELVETICA CHIMICA ACTA (2018)

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High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

Lukasz Opalinski et al.

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Chemo- and Regioselective Lysine Modification on Native Proteins

Maria J. Matos et al.

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Biomineralized Metal-Organic Framework Nanoparticles Enable Intracellular Delivery and Endo-Lysosomal Release of Native Active Proteins

Ting-Ting Chen et al.

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Development of a Light-Controlled Nanoplatform for Direct Nuclear Delivery of Molecular and Nanoscale Materials

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N-terminal alpha-amino group modification of antibodies using a site-selective click chemistry method

De-zhi Li et al.

MABS (2018)

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The less-is-more in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity

Natasha A. Pereira et al.

MABS (2018)

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Liposomal nanoparticle armed with bivalent bispecific single-domain antibodies, novel weapon in HER2 positive cancerous cell lines targeting

Shahryar Khoshtinat Nikkhoi et al.

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mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

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The promise and challenges of immune agonist antibody development in cancer

Patrick A. Mayes et al.

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In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

Chao Wang et al.

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Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Raffaella Rossin et al.

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Bispecific antibodies: design, therapy, perspectives

Sergey E. Sedykh et al.

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A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway

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Strategies for Generating Diverse Antibody Repertoires Using Transgenic Animals Expressing Human Antibodies

Weihsu C. Chen et al.

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Monoclonal Antibody Therapies for Hematological Malignancies: Not Just Lineage-Specific Targets

Carlos Cuesta-Mateos et al.

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Antibody-Bridged Beacon for Homogeneous Detection of Small Molecules

Xiaowen Yan et al.

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Chemoenzymatic Methods for the Synthesis of Glycoproteins

Chao Li et al.

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Cancer cell nucleus-targeting nanocomposites for advanced tumor therapeutics

Limin Pan et al.

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Monitoring T cell-dendritic cell interactions in vivo by intercellular enzymatic labelling

Giulia Pasqual et al.

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A proximity-tagging system to identify membrane protein-protein interactions

Qiang Liu et al.

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Live-cell labeling of endogenous proteins with nanometer precision by transduced nanobodies

A. Klein et al.

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Synthetic materials at the forefront of gene delivery

Irene Lostale-Seijo et al.

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Convenient and Universal Fabrication Method for Antibody-Enzyme Complexes as Sensing Elements Using the SpyCatcher/SpyTag System

Hayato Kimura et al.

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Proximity-Induced Site-Specific Antibody Conjugation

Chenfei Yu et al.

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Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads

Amit Kumar et al.

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A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

Miguel F. Sanmamed et al.

CELL (2018)

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Bypassing Endocytosis: Direct Cytosolic Delivery of Proteins

Shubo Du et al.

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Potent Protein Delivery into Mammalian Cells via a Supercharged Polypeptide

Jun Yin et al.

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A Review on Electroporation-Based Intracellular Delivery

Junfeng Shi et al.

MOLECULES (2018)

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Targeted Intracellular Delivery of Antibodies: The State of the Art

Tatiana A. Slastnikova et al.

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Immune checkpoint inhibitors: recent progress and potential biomarkers

Pramod Darvin et al.

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Enzyme-Based Labeling Strategies for Antibody-Drug Conjugates and Antibody Mimetics

Georg Falck et al.

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Anti-EGFR lipid micellar nanoparticles co-encapsulating quantum dots and paclitaxel for tumor-targeted theranosis

Seong Jae Kang et al.

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Antigen-responsive fluorescent antibody probes generated by selective N-terminal modification of IgGs

Keisuke Fukunaga et al.

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Monoclonal Antibodies: A Review

Surjit Singh et al.

CURRENT CLINICAL PHARMACOLOGY (2018)

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Beyond binding: antibody effector functions in infectious diseases

Lenette L. Lu et al.

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Orthogonal Cysteine Protection Enables Homogeneous Multi-Drug Antibody-Drug Conjugates

Matthew R. Levengood et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Cell-penetrating peptides with intracellular organelle targeting

Carmine Pasquale Cerrato et al.

EXPERT OPINION ON DRUG DELIVERY (2017)

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An L- to D-Amino Acid Conversion in an Endosomolytic Analog of the Cell- penetrating Peptide TAT Influences Proteolytic Stability, Endocytic Uptake, and Endosomal Escape

Kristina Najjar et al.

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First-in-human assessment of PRX002, an anti--synuclein monoclonal antibody, in healthy volunteers

Dale B. Schenk et al.

MOVEMENT DISORDERS (2017)

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Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates

Sergii Kolodych et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Glycosylation of IgG-Fc: a molecular perspective

Masato Kiyoshi et al.

INTERNATIONAL IMMUNOLOGY (2017)

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Development and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload

Yanming Wang et al.

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A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug Conjugates

Ying Xu et al.

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Activatable clinical fluorophore-quencher antibody pairs as dual molecular probes for the enhanced specificity of image-guided surgery

Girgis Obaid et al.

JOURNAL OF BIOMEDICAL OPTICS (2017)

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Antibody-Drug Conjugates as Cancer Therapeutics: Past, Present, and Future

Heather E. Vezina et al.

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Targeted cancer therapy through antibody fragments-decorated nanomedicines

Abbas Alibakhshi et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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A Hexa-rhodium Metallopeptide Catalyst for Site-Specific Functionalization of Natural Antibodies

Jun Ohata et al.

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Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones

Yingqian Zhang et al.

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Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags

Rui Tang et al.

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Cytosolic Delivery of Proteins by Bioreversible Esterification

Kalie A. Mix et al.

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The making of bispecific antibodies

Ulrich Brinkmann et al.

MABS (2017)

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Bispecific Antibodies and Antibody-Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs

Julian Andreev et al.

MOLECULAR CANCER THERAPEUTICS (2017)

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Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity

Daniela Kalafatovic et al.

MOLECULES (2017)

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Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries

Joel W. Blanchard et al.

NATURE BIOTECHNOLOGY (2017)

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Targeting the N terminus for site-selective protein modification

Christian B. Rosen et al.

NATURE CHEMICAL BIOLOGY (2017)

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Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

Misao Akishiba et al.

NATURE CHEMISTRY (2017)

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Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells

Henry D. Herce et al.

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α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

Yvette C. Wong et al.

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Strategies and challenges for the next generation of antibody drug conjugates

Alain Beck et al.

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Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?

Michaela Seeling et al.

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Stimuli-responsive polymers and their applications

Menglian Wei et al.

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Modulating Cytotoxic Effector Functions by Fc Engineering to Improve Cancer Therapy

Christian Kellner et al.

TRANSFUSION MEDICINE AND HEMOTHERAPY (2017)

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The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

Yong Tae Kwon et al.

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Affibody Molecules in Biotechnological and Medical Applications

Stefan Stahl et al.

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The Immunoregulatory Roles of Antibody Glycosylation

Madeleine F. Jennewein et al.

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A red-emissive antibody-AIEgen conjugate for turn-on and wash-free imaging of specific cancer cells

Xiujuan Shi et al.

CHEMICAL SCIENCE (2017)

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Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates

Alex R. Nanna et al.

NATURE COMMUNICATIONS (2017)

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Intracellular trafficking of new anticancer therapeutics: antibody-drug conjugates

Muhammad Kalim et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2017)

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Pyridazinediones deliver potent, stable, targeted and efficacious antibody-drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody

Eifion Robinson et al.

RSC ADVANCES (2017)

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A quantitative comparison of cytosolic delivery via different protein uptake systems

Wouter P. R. Verdurmen et al.

SCIENTIFIC REPORTS (2017)

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Liposomal Nanoparticles Carrying anti-IL6R Antibody to the Tumour Microenvironment Inhibit Metastasis in Two Molecular Subtypes of Breast Cancer Mouse Models

Chunlei Guo et al.

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Development of a CHO-Based Cell-Free Platform for Synthesis of Active Monoclonal Antibodies

Rey W. Martin et al.

ACS SYNTHETIC BIOLOGY (2017)

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Therapeutic Antibodies against Intracellular Tumor Antigens

Iva Trenevska et al.

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Antibody or Antibody Fragments: Implications for Molecular Imaging and Targeted Therapy of Solid Tumors

Katerina T. Xenaki et al.

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Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

Peter Bannas et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains

I-Ju Chen et al.

SCIENTIFIC REPORTS (2017)

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Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required?

Alexander H. Staudacher et al.

BRITISH JOURNAL OF CANCER (2017)

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A Method for the Acute and Rapid Degradation of Endogenous Proteins

Dean Clift et al.

CELL (2017)

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Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?

Peter J. Lenting et al.

BLOOD (2017)

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Intracellular Delivery of Functional Native Antibodies under Hypoxic Conditions by Using a Biodegradable Silica Nanoquencher

Peiyan Yuan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Development of a Quenchbody for the Detection and Imaging of the Cancer-Related Tight-Junction-Associated Membrane Protein Claudin

Hee-Jin Jeong et al.

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Engineering the Surface of Smart Nanocarriers Using a pH-/Thermal-/GSH-Responsive Polymer Zipper for Precise Tumor Targeting Therapy In Vivo

Penghui Zhang et al.

ADVANCED MATERIALS (2017)

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Drugging the 'undruggable' cancer targets

Chi V. Dang et al.

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General Strategy for Direct Cytosolic Protein Delivery via Protein-Nanoparticle Co-engineering

Rubul Mout et al.

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Acyl Fluorides: Fast, Efficient, and Versatile Lysine-Based Protein Conjugation via Plug-and-Play Strategy

Igor Dovgan et al.

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Improving Antibody-Based Cancer Therapeutics Through Glycan Engineering

Xiaojie Yu et al.

BIODRUGS (2017)

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When to initiate immunoglobulin replacement therapy (IGRT) in antibody deficiency: a practical approach

S. Jolles et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)

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Affibody molecules as engineered protein drugs

Fredrik Y. Frejd et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

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Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies

Fa Yang et al.

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Tumor Microenvironment Activated Membrane Fusogenic Liposome with Speedy Antibody and Doxorubicin Delivery for Synergistic Treatment of Metastatic Tumors

Hongzhang Deng et al.

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Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing

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Breakable Hybrid Organosilica Nanocapsules for Protein Delivery

Eko Adi Prasetyanto et al.

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Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases

Yuping Lai et al.

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Influence of molecular size on tissue distribution of antibody fragments

Zhe Li et al.

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Site-selective protein-modification chemistry for basic biology and drug development

Nikolaus Krall et al.

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T cell receptor mimic antibodies for cancer therapy

Leonid Dubrovsky et al.

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Ultrastable and Biofunctionalizable Gold Nanoparticles

Akash Gupta et al.

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Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer

Haiqiang Cao et al.

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Covalent and Oriented Surface Immobilization of Antibody Using Photoactivatable Antibody Fc-Binding Protein Expressed in Escherichia coli

Yeolin Lee et al.

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Cell-Penetrating Poly(disulfide) Assisted Intracellular Delivery of Mesoporous Silica Nanoparticles for Inhibition of miR-21 Function and Detection of Subsequent Therapeutic Effects

Changmin Yu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Drugging Undruggable Molecular Cancer Targets

John S. Lazo et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 (2016)

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Immuno-PCR: achievements and perspectives

D. Y. Ryazantsev et al.

BIOCHEMISTRY-MOSCOW (2016)

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Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs

Jeffrey C. Kern et al.

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Future of nanotherapeutics: Targeting the cellular sub-organelles

Xiaowei Ma et al.

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Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads

Takashi Nakada et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

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Therapeutic monoclonal antibodies and derivatives: Historical perspectives and future directions

Kyla R. Rodgers et al.

BIOTECHNOLOGY ADVANCES (2016)

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Immune-related adverse events with immune checkpoint blockade: a comprehensive review

J. M. Michot et al.

EUROPEAN JOURNAL OF CANCER (2016)

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Opportunities and challenges for TCR mimic antibodies in cancer therapy

Aaron Y. Chang et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2016)

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The ubiquitin-proteasome system and autophagy: Coordinated and independent activities

Victoria Cohen-Kaplan et al.

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Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding

Emma Dave et al.

MABS (2016)

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Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins

Prince Awuah et al.

MOLECULAR CANCER THERAPEUTICS (2016)

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Mechanisms of Resistance to Antibody-Drug Conjugates

Frank Loganzo et al.

MOLECULAR CANCER THERAPEUTICS (2016)

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A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells

Rajeeva Singh et al.

MOLECULAR CANCER THERAPEUTICS (2016)

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Altering Antibody-Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability

Kevin J. Hamblet et al.

MOLECULAR PHARMACEUTICS (2016)

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Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins

David J. Marshall et al.

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Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

Chao Wang et al.

NANO LETTERS (2016)

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In vitro and ex vivo strategies for intracellular delivery

Martin P. Stewart et al.

NATURE (2016)

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Development and application of bond cleavage reactions in bioorthogonal chemistry

Jie Li et al.

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Spatiotemporal dynamics of the nuclear pore complex transport barrier resolved by high-speed atomic force microscopy

Yusuke Sakiyama et al.

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Small molecules, big targets: drug discovery faces the protein-protein interaction challenge

Duncan E. Scott et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

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Ethynyl benziodoxolones: functional terminators for cell-penetrating poly(disulfide)s

Paola Morelli et al.

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Precision glycocalyx editing as a strategy for cancer immunotherapy

Han Xiao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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DNA Nanostructures Carrying Stoichiometrically Definable Antibodies

Magdiel Inggrid Setyawati et al.

SMALL (2016)

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Construction of homogeneous antibody-drug conjugates using site-selective protein chemistry

Padma Akkapeddi et al.

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Next-generation disulfide stapling: reduction and functional re-bridging all in one

Maximillian T. W. Lee et al.

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Straightforward Glycoengineering Approach to Site-Specific Antibody-Pyrrolobenzodiazepine Conjugates

Pamela Thompson et al.

ACS MEDICINAL CHEMISTRY LETTERS (2016)

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Leveraging the attributes of biologics and small molecules, and releasing the bottlenecks: a new wave of revolution in drug development

Charles Oo et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2016)

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Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm?

Andrea L. J. Marschall et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2016)

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Review Medicine, Research & Experimental

Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications

Zhengrong Guo et al.

BIOMEDICAL REPORTS (2016)

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Meeting Abstract Hematology

Argx-113, a Novel Fc-Based Approach for Antibody-Induced Pathologies Such As Primary Immune Thrombocytopenia

Peter Ulrichts et al.

BLOOD (2016)

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Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry

Jessica R. McCombs et al.

AAPS JOURNAL (2015)

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The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy

Jonathan T. Sockolosky et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

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Article Biochemical Research Methods

IgG subclass specificity to C1q determined by surface plasmon resonance using Protein L capture technique

Rekha Patel et al.

ANALYTICAL BIOCHEMISTRY (2015)

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Article Chemistry, Multidisciplinary

Protein Delivery System Containing a Nickel-Immobilized Polymer for Multimerization of Affinity-Purified His-Tagged Proteins Enhances Cytosolic Transfer

Viktoriia Postupalenko et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

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Article Biochemistry & Molecular Biology

A Perspective on the Structure and Receptor Binding Properties of Immunoglobulin G Fc

Quinlin M. Hanson et al.

BIOCHEMISTRY (2015)

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Article Biochemical Research Methods

Hydrolytically Stable Site-Specific Conjugation at the N-Terminus of an Engineered Antibody

Pamela Thompson et al.

BIOCONJUGATE CHEMISTRY (2015)

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Review Biochemical Research Methods

Site-Specific Antibody-Drug Conjugates: The Nexus of Biciorthogonal Chemistry, Protein Engineering, and Drug Development

Paresh Agarwal et al.

BIOCONJUGATE CHEMISTRY (2015)

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Review Biochemistry & Molecular Biology

Antibody-drug conjugates as novel anti-cancer chemotherapeutics

Christina Peters et al.

BIOSCIENCE REPORTS (2015)

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Editorial Material Biochemistry & Molecular Biology

Releasing the Brakes on Cancer Immunotherapy

Dan R. Littman

CELL (2015)

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Cellular uptake: lessons from supramolecular organic chemistry

Giulio Gasparini et al.

CHEMICAL COMMUNICATIONS (2015)

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Protein-polymer conjugation - moving beyond PEGylation

Yizhi Qi et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2015)

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A Fusion Protein of RGD4C and β-Lactamase Has a Favorable Targeting Effect in Its Use in Antibody Directed Enzyme Prodrug Therapy

Hao Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Review Biochemistry & Molecular Biology

Site-Specific PEGylation of Therapeutic Proteins

Jonathan K. Dozier et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Article Chemistry, Multidisciplinary

Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides

R. James Christie et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Multidisciplinary

PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo

Kadi-Liis Veiman et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo

Margie Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Article Chemistry, Multidisciplinary

Analysis of Cell-Surface Receptor Dynamics through Covalent Labeling by Catalyst-Tethered Antibody

Takahiro Hayashi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Article Chemistry, Multidisciplinary

Intracellular Delivery of Functional Proteins and Native Drugs by Cell-Penetrating Poly(disulfide)s

Jiaqi Fu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Article Medicine, Research & Experimental

De novo isolation of antibodies with pH-dependent binding properties

Pauline Bonvin et al.

MABS (2015)

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Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation

Michal Bassani-Sternberg et al.

MOLECULAR & CELLULAR PROTEOMICS (2015)

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Review Biochemistry & Molecular Biology

Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

Vashti Irani et al.

MOLECULAR IMMUNOLOGY (2015)

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Review Biochemistry & Molecular Biology

In vivo imaging with antibodies and engineered fragments

Amanda C. Freise et al.

MOLECULAR IMMUNOLOGY (2015)

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Antibody Conjugates with Unnatural Amino Acids

Trevor J. Hallam et al.

MOLECULAR PHARMACEUTICS (2015)

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Light-Controlled Delivery of Monoclonal Antibodies for Targeted Photoinactivation of Ki-67

Sijia Wang et al.

MOLECULAR PHARMACEUTICS (2015)

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Article Multidisciplinary Sciences

Organometallic palladium reagents for cysteine bioconjugation

Ekaterina V. Vinogradova et al.

NATURE (2015)

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Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

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Article Biochemistry & Molecular Biology

One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

James I. MacDonald et al.

NATURE CHEMICAL BIOLOGY (2015)

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Article Chemistry, Organic

Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

Nicolas Chuard et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

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Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

Pietro Sormanni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Pathology

Therapeutic antibodies: their mechanisms of action and the pathological findings they induce in toxicity studies

Masami Suzuki et al.

Journal of Toxicologic Pathology (2015)

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Proximity-dependent initiation of hybridization chain reaction

Bjorn Koos et al.

NATURE COMMUNICATIONS (2015)

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Review Immunology

History of passive antibody administration for prevention and treatment of infectious diseases

Barney S. Graham et al.

CURRENT OPINION IN HIV AND AIDS (2015)

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Review Immunology

NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy

Wei Wang et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Targeted Delivery of Protein and Gene Medicines Through the Blood-Brain Barrier

W. M. Pardridge

CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)

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Review Immunology

Natural Antibodies Bridge Innate and Adaptive Immunity

Saswati Panda et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Biochemical Research Methods

Directed evolution of APEX2 for electron microscopy and proximity labeling

Stephanie S. Lam et al.

NATURE METHODS (2015)

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Article Biochemical Research Methods

A Cell-Based Internalization and Degradation Assay with an Activatable Fluorescence-Quencher Probe as a Tool for Functional Antibody Screening

Yan Li et al.

JOURNAL OF BIOMOLECULAR SCREENING (2015)

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Review Oncology

Building better monoclonal antibody-based therapeutics

George J. Weiner

NATURE REVIEWS CANCER (2015)

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Review Biochemical Research Methods

New Horizons in Therapeutic Antibody Discovery: Opportunities and Challenges versus Small-Molecule Therapeutics

Alison J. Smith

JOURNAL OF BIOMOLECULAR SCREENING (2015)

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Article Chemistry, Multidisciplinary

Preparation of Well-Defined Antibody-Drug Conjugates through Glycan Remodeling and Strain-Promoted Azide-Alkyne Cycloadditions

Xiuru Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Article Chemistry, Multidisciplinary

Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy

Ming Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Review Biochemistry & Molecular Biology

From fluorescence polarization to Quenchbody: Recent progress in fluorescent reagentless biosensors based on antibody and other binding proteins

Hiroshi Ueda et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2014)

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Article Biochemical Research Methods

Bridging Disulfides for Stable and Defined Antibody Drug Conjugates

George Badescu et al.

BIOCONJUGATE CHEMISTRY (2014)

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Article Biochemical Research Methods

Selective Irreversible Chemical Tagging of Cysteine with 3-Arylpropiolonitriles

Oleksandr Koniev et al.

BIOCONJUGATE CHEMISTRY (2014)

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Article Biochemical Research Methods

Site-Specific Antibody-Drug Conjugation through Glycoengineering

Qun Zhou et al.

BIOCONJUGATE CHEMISTRY (2014)

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Review Biochemical Research Methods

Promises and Pitfalls of Intracellular Delivery of Proteins

Ailing Fu et al.

BIOCONJUGATE CHEMISTRY (2014)

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Article Engineering, Biomedical

Nucleic acid-mediated intracellular protein delivery by lipid-like nanoparticles

Ahmed A. Eltoukhy et al.

BIOMATERIALS (2014)

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Review Oncology

Trastuzumab emtansine: mechanisms of action and drug resistance

Mark Barok et al.

BREAST CANCER RESEARCH (2014)

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Review Allergy

Immunoglobulin Replacement Therapy: A Twenty-Year Review and Current Update

Monika Saeedian et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2014)

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Article Oncology

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

Suzanne L. Topalian et al.

JOURNAL OF CLINICAL ONCOLOGY (2014)

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Review Pharmacology & Pharmacy

Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering

Yuan Wang et al.

JOURNAL OF DRUG TARGETING (2014)

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Article Chemistry, Multidisciplinary

Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s

Giulio Gasparini et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Article Biochemistry & Molecular Biology

Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging

Victoria Hung et al.

MOLECULAR CELL (2014)

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Review Medicine, Research & Experimental

Antibodies directed against receptor tyrosine kinases Current and future strategies to fight cancer

Benedicte Fauvel et al.

MABS (2014)

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Article Biotechnology & Applied Microbiology

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

Robert P. Lyon et al.

NATURE BIOTECHNOLOGY (2014)

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Article Biochemical Research Methods

Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT

Ralf Jungmann et al.

NATURE METHODS (2014)

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Article Chemistry, Organic

Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

Felix F. Schumacher et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2014)

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Article Multidisciplinary Sciences

Homogenous 96-Plex PEA Immunoassay Exhibiting High Sensitivity, Specificity, and Excellent Scalability

Erika Assarsson et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

Christoph A. Diebolder et al.

SCIENCE (2014)

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Article Cell Biology

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Y. Joy Yu et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

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Review Oncology

The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer

Ross Stewart et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2014)

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Article Microbiology

Functions of Antibodies

Donald N. Forthal

MICROBIOLOGY SPECTRUM (2014)

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Article Chemistry, Analytical

Breeding Diagnostic Antibodies for Higher Assay Performance: A 250-Fold Affinity-Matured Antibody Mutant Targeting a Small Biomarker

Hiroyuki Oyama et al.

ANALYTICAL CHEMISTRY (2013)

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Article Chemistry, Multidisciplinary

Rapid, Stable, Chemoselective Labeling of Thiols with Julia-Kocienski-like Reagents: A Serum-Stable Alternative to Maleimide-Based Protein Conjugation

Narihiro Toda et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

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Article Chemistry, Multidisciplinary

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

Ron M. Versteegen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

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Article Biochemical Research Methods

Metabolic Engineering of Monoclonal Antibody Carbohydrates for Antibody-Drug Conjugation

Nicole M. Okeley et al.

BIOCONJUGATE CHEMISTRY (2013)

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Article Biochemical Research Methods

Enzyme-Mediated Methodology for the Site-Specific Radiolabeling of Antibodies Based on Catalyst-Free Click Chemistry

Brian M. Zeglis et al.

BIOCONJUGATE CHEMISTRY (2013)

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Article Engineering, Biomedical

Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site

Nathan J. Alves et al.

BIOMATERIALS (2013)

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Review Biochemistry & Molecular Biology

Antibody humanization methods - a review and update

Yaghoub Safdari et al.

BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 29, ISSUE 2 (2013)

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Article Pharmacology & Pharmacy

Anti-TNF Antibodies in Inflammatory Bowel Disease: Do We Finally Know How it Works?

Angelos Oikonomopoulos et al.

CURRENT DRUG TARGETS (2013)

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Review Biochemistry & Molecular Biology

Cell-penetrating peptides: 20 years later, where do we stand?

Cherine Bechara et al.

FEBS LETTERS (2013)

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Article Allergy

Controversies in IgG replacement therapy in patients with antibody deficiency diseases

Erwin W. Gelfand et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Article Chemistry, Physical

Sub-150 nm mesoporous silica nanoparticles with tunable pore sizes and well-ordered mesostructure for protein encapsulation

Jinlou Gu et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2013)

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Article Chemistry, Multidisciplinary

Substrate-Initiated Synthesis of Cell-Penetrating Poly(disulfide)s

Eun-Kyoung Bang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

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Article Chemistry, Multidisciplinary

Site-Specific Protein Transannination Using N-Methylpyridinium-4-carboxaldehyde

Leah S. Witus et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

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Article Chemistry, Multidisciplinary

Site-Specific Antibody-Polymer Conjugates for siRNA Delivery

Hua Lu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

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Article Medicine, Research & Experimental

Approaches to improve tumor accumulation and interactions between monoclonal antibodies and immune cells

Fabrizio Marcucci et al.

MABS (2013)

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Article Medicine, Research & Experimental

Targeting endogenous nuclear antigens by electrotransfer of monoclonal antibodies in living cells

Guillaume Freund et al.

MABS (2013)

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Review Rheumatology

Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis

Pauline A. van Schouwenburg et al.

NATURE REVIEWS RHEUMATOLOGY (2013)

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Review Clinical Neurology

Developing Therapeutic Antibodies for Neurodegenerative Disease

Y. Joy Yu et al.

NEUROTHERAPEUTICS (2013)

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Review Multidisciplinary Sciences

Antibody Therapeutics in Cancer

Mark X. Sliwkowski et al.

SCIENCE (2013)

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Article Multidisciplinary Sciences

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

Hyun-Woo Rhee et al.

SCIENCE (2013)

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Article Chemistry, Multidisciplinary

Reversible blocking of antibodies using bivalent peptide-DNA conjugates allows protease-activatable targeting

Brian M. G. Janssen et al.

CHEMICAL SCIENCE (2013)

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Review Immunology

Intravenous immunoglobulin therapy: how does IgG modulate the immune system?

Inessa Schwab et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Review Pharmacology & Pharmacy

Microneedles for drug and vaccine delivery

Yeu-Chun Kim et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Article Biochemical Research Methods

Reagents for Astatination of Biomolecules. 6. An Intact Antibody Conjugated with a Maleimido-closo-Decaborate(2-) Reagent via Sulfhydryl Groups Had Considerably Higher Kidney Concentrations than the Same Antibody Conjugated with an Isothiocyanato-closo-Decaborate(2-) Reagent via Lysine Amines

D. Scott Wilbur et al.

BIOCONJUGATE CHEMISTRY (2012)

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Article Biochemical Research Methods

DOTAGA-Trastuzumab. A New Antibody Conjugate Targeting HER2/Neu Antigen for Diagnostic Purposes

Mathieu Moreau et al.

BIOCONJUGATE CHEMISTRY (2012)

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Article Engineering, Biomedical

Influence of architecture of high molecular weight linear and branched polyglycerols on their biocompatibility and biodistribution

Muhammad Imran ul-Haq et al.

BIOMATERIALS (2012)

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Article Oncology

Antigen Shedding May Improve Efficiencies for Delivery of Antibody-Based Anticancer Agents in Solid Tumors

Youngshang Pak et al.

CANCER RESEARCH (2012)

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Review Biochemistry & Molecular Biology

Antibody-Based Immunotherapy of Cancer

Louis M. Weiner et al.

CELL (2012)

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Article Chemistry, Multidisciplinary

Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format

Kathrin Zuberbuehler et al.

CHEMICAL COMMUNICATIONS (2012)

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Review Chemistry, Multidisciplinary

Synthesis of Metal-Organic Frameworks (MOFs): Routes to Various MOF Topologies, Morphologies, and Composites

Norbert Stock et al.

CHEMICAL REVIEWS (2012)

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Article Biochemistry & Molecular Biology

Cellular Uptake Mechanisms and Endosomal Trafficking of Supercharged Proteins

David B. Thompson et al.

CHEMISTRY & BIOLOGY (2012)

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Article Pharmacology & Pharmacy

Monoclonal antibody therapeutics: history and future

Nicholas A. P. S. Buss et al.

CURRENT OPINION IN PHARMACOLOGY (2012)

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Article Biochemistry & Molecular Biology

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

Tengfei Li et al.

FASEB JOURNAL (2012)

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Meeting Abstract Immunology

CD20 mAb-mediated C3b deposition and complement dependent cytotoxicity of tumor cells is enhanced by blocking the action of Factor I

Ronald P. Taylor et al.

IMMUNOBIOLOGY (2012)

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Article Chemistry, Multidisciplinary

Recombinant peptide constructs for targeted cell penetrating peptide-mediated delivery

Jennica L. Zaro et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Review Medicine, Research & Experimental

Disulfide bond structures of IgG molecules Structural variations, chemical modifications and possible impacts to stability and biological function

Hongcheng Liu et al.

MABS (2012)

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Article Medicine, Research & Experimental

Aglycosylated antibodies and antibody fragments produced in a scalable in vitro transcription-translation system

Gang Yin et al.

MABS (2012)

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Article Biotechnology & Applied Microbiology

Antibody-enabled small-molecule drug discovery

Alastair D. G. Lawson

NATURE REVIEWS DRUG DISCOVERY (2012)

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Review Oncology

Antibody therapy of cancer

Andrew M. Scott et al.

NATURE REVIEWS CANCER (2012)

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Review Chemistry, Analytical

Antibody engineering toward high-sensitivity high-throughput immunosensing of small molecules

Norihiro Kobayashi et al.

ANALYST (2011)

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Immuno-Hybridization Chain Reaction for Enhancing Detection of Individual Cytokine-Secreting Human Peripheral Mononuclear Cells

Jonghoon Choi et al.

ANALYTICAL CHEMISTRY (2011)

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Article Biochemistry & Molecular Biology

Kinetics of reduction of tyrosine phenoxyl radicals by glutathione

Lisa K. Folkes et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)

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Review Biochemistry & Molecular Biology

How viruses access the nucleus

Sarah Cohen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

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Article Biochemical Research Methods

Disulfide-Linked Antibody-Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage

Brenda A. Kellogg et al.

BIOCONJUGATE CHEMISTRY (2011)

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Article Biochemical Research Methods

Near-Infrared pH-Activatable Fluorescent Probes for Imaging Primary and Metastatic Breast Tumors

Hyeran Lee et al.

BIOCONJUGATE CHEMISTRY (2011)

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Review Chemistry, Multidisciplinary

Tailoring nanocarriers for intracellular protein delivery

Zhen Gu et al.

CHEMICAL SOCIETY REVIEWS (2011)

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Review Chemistry, Multidisciplinary

Gold nanostructures: a class of multifunctional materials for biomedical applications

Claire M. Cobley et al.

CHEMICAL SOCIETY REVIEWS (2011)

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Article Biochemistry & Molecular Biology

A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo

James J. Cronican et al.

CHEMISTRY & BIOLOGY (2011)

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Article Oncology

Antibody Conjugate Therapeutics: Challenges and Potential

Beverly A. Teicher et al.

CLINICAL CANCER RESEARCH (2011)

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Article Chemistry, Multidisciplinary

Nuclear drug delivery for cancer chemotherapy

Meihua Sui et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Chemistry, Medicinal

Identification of Amino Acid Residues Responsible for the Release of Free Drug from an Antibody-Drug Conjugate Utilizing Lysine-Succinimidyl Ester Chemistry

Hung-Wei Chih et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

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Article Chemistry, Multidisciplinary

Quenchbodies: Quench-Based Antibody Probes That Show Antigen-Dependent Fluorescence

Ryoji Abe et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Biochemistry & Molecular Biology

Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood

Martin Lundberg et al.

NUCLEIC ACIDS RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Immuno-PCR: a promising ultrasensitive diagnostic method to detect antigens and antibodies

Nada Malou et al.

TRENDS IN MICROBIOLOGY (2011)

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Article Biochemistry & Molecular Biology

Potent Delivery of Functional Proteins into Mammalian Cells in Vitro and in Vivo Using a Supercharged Protein

James J. Cronican et al.

ACS CHEMICAL BIOLOGY (2010)

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Article Chemistry, Multidisciplinary

Efficient Delivery of Bioactive Antibodies into the Cytoplasm of Living Cells by Charge-Conversional Polyion Complex Micelles

Yan Lee et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

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Article Biochemical Research Methods

Intracellular Delivery of a Protein Antigen with an Endosomal-Releasing Polymer Enhances CD8 T-Cell Production and Prophylactic Vaccine Efficacy

Suzanne Foster et al.

BIOCONJUGATE CHEMISTRY (2010)

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Review Chemistry, Multidisciplinary

New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging

Hisataka Kobayashi et al.

CHEMICAL REVIEWS (2010)

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Review Biochemical Research Methods

Proximity ligation assays: a recent addition to the proteomics toolbox

Irene Weibrecht et al.

EXPERT REVIEW OF PROTEOMICS (2010)

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Review Biochemistry & Molecular Biology

Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications

J. Lofblom et al.

FEBS LETTERS (2010)

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Article Allergy

Adaptive immunity

Francisco A. Bonilla et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Chemistry, Multidisciplinary

Intracellular Delivery of a Membrane-Impermeable Enzyme in Active Form Using Functionalized Gold Nanoparticles

Partha Ghosh et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

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Article Biochemistry & Molecular Biology

High sensitivity detection of cancer in vivo using a dual-controlled activation fluorescent imaging probe based on H-dimer formation and pH activation

Mikako Ogawa et al.

MOLECULAR BIOSYSTEMS (2010)

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Review Biotechnology & Applied Microbiology

The safety and side effects of monoclonal antibodies

Trevor T. Hansel et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

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Article Hematology

CD20-Targeted Therapy: The Next Generation of Antibodies

Tom van Meerten et al.

SEMINARS IN HEMATOLOGY (2010)

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Article Chemistry, Medicinal

Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC

Akito Natsume

Drug Design Development and Therapy (2010)

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Article Immunology

Strategies and challenges for the next generation of therapeutic antibodies

Alain Beck et al.

NATURE REVIEWS IMMUNOLOGY (2010)

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Review Immunology

Monoclonal antibodies: versatile platforms for cancer immunotherapy

Louis M. Weiner et al.

NATURE REVIEWS IMMUNOLOGY (2010)

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Review Immunology

Therapeutic antibodies for autoimmunity and inflammation

Andrew C. Chan et al.

NATURE REVIEWS IMMUNOLOGY (2010)

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Article Biochemistry & Molecular Biology

H-Type Dimer Formation of Fluorophores: A Mechanism for Activatable, in Vivo Optical Molecular Imaging

Mikako Ogawa et al.

ACS CHEMICAL BIOLOGY (2009)

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Article Chemistry, Analytical

Photoactivable Antibody Binding Protein: Site-Selective and Covalent Coupling of Antibody

Yongwon Jung et al.

ANALYTICAL CHEMISTRY (2009)

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Article Chemistry, Analytical

Antigen Peptide-Based Immunosensors for Rapid Detection of Antibodies and Antigens

Ling Tian et al.

ANALYTICAL CHEMISTRY (2009)

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Article Chemistry, Multidisciplinary

Charge-Conversional Polyionic Complex Micelles-Efficient Nanocarriers for Protein Delivery into Cytoplasm

Yan Lee et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

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Article Biochemical Research Methods

New Strategy for the Extension of the Serum Half-Life of Antibody Fragments

Sabrina Truessel et al.

BIOCONJUGATE CHEMISTRY (2009)

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Article Chemistry, Medicinal

β-Lactam-based approach for the chemical programming of aldolase antibody 38C2

Julia I. Gavrilyuk et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

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Review Pharmacology & Pharmacy

Therapeutic antibodies: successes, limitations and hopes for the future

Patrick Chames et al.

BRITISH JOURNAL OF PHARMACOLOGY (2009)

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Review Biochemistry & Molecular Biology

Antibody-Directed Enzyme Prodrug Therapy: A Promising Approach for a Selective Treatment of Cancer Based on Prodrugs and Monoclonal Antibodies

Lutz F. Tietze et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2009)

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Article Chemistry, Multidisciplinary

Electron-Deficient Alkynes as Cleavable Reagents for the Modification of Cysteine-Containing Peptides in Aqueous Medium

Hoi-Yan Shiu et al.

CHEMISTRY-A EUROPEAN JOURNAL (2009)

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Article Oncology

The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells In vitro and In vivo

Hiroshi Ikeda et al.

CLINICAL CANCER RESEARCH (2009)

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Article Oncology

In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies

Mikako Ogawa et al.

MOLECULAR CANCER THERAPEUTICS (2009)

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Review Medicine, Research & Experimental

Human immunoglobulin allotypes Possible implications for immunogenicity

Roy Jefferis et al.

MABS (2009)

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Article Biotechnology & Applied Microbiology

Development trends for therapeutic antibody fragments

Aaron L. Nelson et al.

NATURE BIOTECHNOLOGY (2009)

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Article Biochemistry & Molecular Biology

Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes

Yasuteru Urano et al.

NATURE MEDICINE (2009)

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Review Biotechnology & Applied Microbiology

Glycosylation as a strategy to improve antibody-based therapeutics

Roy Jefferis

NATURE REVIEWS DRUG DISCOVERY (2009)

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Article Biochemical Research Methods

Two routes for production and purification of Fab fragments in biopharmaceutical discovery research: Papain digestion of mAb and transient expression in mammalian cells

Yonghong Zhao et al.

PROTEIN EXPRESSION AND PURIFICATION (2009)

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Article Biochemical Research Methods

Comparison of Cellular Uptake Using 22 CPPs in 4 Different Cell Lines

Judith Mueller et al.

BIOCONJUGATE CHEMISTRY (2008)

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Article Biochemical Research Methods

Contribution of linker stability to the activities of anticancer immunoconjugates

Stephen C. Alley et al.

BIOCONJUGATE CHEMISTRY (2008)

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Review Oncology

The impact of PEGylation on biological therapies

Francesco M. Veronese et al.

BIODRUGS (2008)

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Article Biochemistry & Molecular Biology

Single-cell microinjection technology in cell biology

Yan Zhang et al.

BIOESSAYS (2008)

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Article Engineering, Biomedical

Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes

Fong-Yu Cheng et al.

BIOMATERIALS (2008)

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Article Oncology

Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities

Akito Natsume et al.

CANCER RESEARCH (2008)

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Review Immunology

Fully human antibodies from transgenic mouse and phage display platforms

Nils Lonberg

CURRENT OPINION IN IMMUNOLOGY (2008)

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Review Biochemistry & Molecular Biology

Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins

Alain Beck et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2008)

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Review Oncology

Strategies for discovering novel cancer biomarkers through utilization of emerging technologies

Vathany Kulasingam et al.

NATURE CLINICAL PRACTICE ONCOLOGY (2008)

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Review Oncology

Paul Ehrlich's magic bullet concept: 100 years of progress

Klaus Strebhardt et al.

NATURE REVIEWS CANCER (2008)

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Article Oncology

The challenge of drugging undruggable targets in cancer: Lessons learned from targeting BCL-2 family members

Gregory L. Verdine et al.

CLINICAL CANCER RESEARCH (2007)

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Article Biotechnology & Applied Microbiology

Size comparison between proteins PEGylated with branched and linear Poly(Ethylene glycol) molecules

Conan J. Fee

BIOTECHNOLOGY AND BIOENGINEERING (2007)

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Article Chemistry, Multidisciplinary

Supercharging proteins can impart unusual resilience

Michael S. Lawrence et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

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Article Biochemistry & Molecular Biology

Regioselective labeling of antibodies through N-terminal transamination

Rebecca A. Scheck et al.

ACS CHEMICAL BIOLOGY (2007)

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Article Biochemical Research Methods

Sensitive protein detection via triple-binder proximity ligation assays

Edith Schallmeiner et al.

NATURE METHODS (2007)

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Review Chemistry, Multidisciplinary

Kinetics, spectroscopy, and computational chemistry of arylnitrenes

N. P. Gritsan et al.

CHEMICAL REVIEWS (2006)

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Article Immunology

Modulation of the effector functions of a human IgG1 through engineering of its hinge region

William F. Dall'Acqua et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Biochemical Research Methods

Development and properties of β-glucuronide linkers for monoclonal antibody-drug conjugates

SC Jeffrey et al.

BIOCONJUGATE CHEMISTRY (2006)

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Review Immunology

Potent antibody therapeutics by design

PJ Carter

NATURE REVIEWS IMMUNOLOGY (2006)

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Article Multidisciplinary Sciences

Engineered antibody Fc variants with enhanced effector function

GA Lazar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Chemistry, Multidisciplinary

Protein ligand design: From phage display to synthetic protein epitope mimetics in human antibody Fc-binding peptidomimetics

RLA Dias et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

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Review Oncology

Comparing antibody and small-molecule therapies for cancer

Kohzoh Imai et al.

NATURE REVIEWS CANCER (2006)

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Article Biotechnology & Applied Microbiology

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels

C Vaccaro et al.

NATURE BIOTECHNOLOGY (2005)

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Article Biochemistry & Molecular Biology

Staphylococcus aureus sortase transpeptidase SrtA:: Insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism

BA Frankel et al.

BIOCHEMISTRY (2005)

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Review Pharmacology & Pharmacy

Cell-penetrating peptides:: mechanism and kinetics of cargo delivery

M Zorko et al.

ADVANCED DRUG DELIVERY REVIEWS (2005)

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Article Biotechnology & Applied Microbiology

Monoclonal antibody successes in the clinic

JM Reichert et al.

NATURE BIOTECHNOLOGY (2005)

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Review Biotechnology & Applied Microbiology

Human antibodies from transgenic animals

N Lonberg

NATURE BIOTECHNOLOGY (2005)

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Review Microbiology

Virus entry: Molecular mechanisms and biomedical applications

DS Dimitrov

NATURE REVIEWS MICROBIOLOGY (2004)

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Review Oncology

Nuclear structure in cancer cells

D Zink et al.

NATURE REVIEWS CANCER (2004)

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Review Microbiology

Passive antibody therapy for infectious diseases

A Casadevall et al.

NATURE REVIEWS MICROBIOLOGY (2004)

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Article Multidisciplinary Sciences

Tumor imaging by means of proteolytic activation of cell-penetrating peptides

T Jiang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Biochemistry & Molecular Biology

Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells

PEG Thorén et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

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Article Biochemistry & Molecular Biology

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcγRIII and antibody-dependent cellular toxicity

RL Shields et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Review Pharmacology & Pharmacy

PEGylated antibodies and antibody fragments for improved therapy: a review

AP Chapman

ADVANCED DRUG DELIVERY REVIEWS (2002)

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Article Biochemistry & Molecular Biology

Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium

A Muruganandam et al.

FASEB JOURNAL (2001)

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Article Biochemistry & Molecular Biology

Intracellular delivery of proteins with a new lipid-mediated delivery system

O Zelphati et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Medicine, General & Internal

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

DJ Slamon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

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Article Immunology

Engineered antibodies with increased activity to recruit complement

EE Idusogie et al.

JOURNAL OF IMMUNOLOGY (2001)

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Review Biochemistry & Molecular Biology

Stability engineering of antibody single-chain Fv fragments

A Wörn et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

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Immunoassays with rolling circle DNA amplification: A versatile platform for ultrasensitive antigen detection

B Schweitzer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Article Multidisciplinary Sciences

Convergent solutions to binding at a protein-protein interface

WL DeLano et al.

SCIENCE (2000)

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