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Skin-Interfaced Wearable Sweat Sensors for Precision Medicine

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Electrowetting valves for sweat-based microfluidics

Aditi R. Naik et al.

Summary: This study demonstrates a solution-based electrowetting valve technology for flexible microfluidic sweat collection patches, with rapid actuation achieved through inkjet printing and laser ablation. Valve actuation time is influenced by applied voltage, not electrode spacing, and can achieve long fluid retention by optimizing conditions. The technology is integrated into a wearable device for artificial perspiration collection.

MICROFLUIDICS AND NANOFLUIDICS (2021)

Article Multidisciplinary Sciences

Wearable plasmonic-metasurface sensor for noninvasive and universal molecular fingerprint detection on biointerfaces

Yingli Wang et al.

Summary: Wearable plasmonic-electronic sensor, combined with flexible sweat extraction system, can noninvasively extract and identify analytes inside the body, providing a means to assess human health.

SCIENCE ADVANCES (2021)

Article Chemistry, Physical

High Performance Printed AgO-Zn Rechargeable Battery for Flexible Electronics

Lu Yin et al.

Summary: The study developed printable polymer-based flexible batteries with features such as flexibility, rechargeability, and high capacity, demonstrating superior performance through detailed testing and analysis. These batteries are suitable for various electronic devices and have significant implications for the future development of high-performance flexible batteries.

JOULE (2021)

Review Biology

A comprehensive review on plasmonic-based biosensors used in viral diagnostics

Anand M. Shrivastav et al.

Summary: The proliferation and transmission of viruses pose a threat to global biosecurity, with early diagnosis and control being critical. Plasmonic-based technologies, such as surface plasmon resonance and surface-enhanced Raman scattering, offer promising solutions for virus detection and biosensor development.

COMMUNICATIONS BIOLOGY (2021)

Article Nanoscience & Nanotechnology

Wearable Osmotic-Capillary Patch for Prolonged Sweat Harvesting and Sensing

Tamoghna Saha et al.

Summary: This study demonstrates the collection of sweat and extraction of biomarkers without the need for active perspiration using a novel hydrogel interface. The results show a correlation between lactate levels in sweat with muscle activity and exercise intensity. This technology has the potential to advance the development of future wearable devices.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Analytical

Smartphone-Addressable 3D-Printed Electrochemical Ring for Nonenzymatic Self-Monitoring of Glucose in Human Sweat

Vassiliki Katseli et al.

Summary: The study presents a wearable glucose monitoring device fabricated through 3D printing, offering nonenzymatic amperometric self-testing of glucose levels in sweat. The device is mechanically bend-resistant and capable of detecting glucose noninvasively in the physiological relevant concentration range without interference from common electroactive metabolites. This 3D-printed wearable sensor bridges the gap between existing fabrication/sensing technologies and the desired operational features for glucose self-monitoring.

ANALYTICAL CHEMISTRY (2021)

Article Engineering, Electrical & Electronic

A Biofuel-Cell-Based Energy Harvester With 86% Peak Efficiency and 0.25-V Minimum Input Voltage Using Source-Adaptive MPPT

Arian Hashemi Talkhooncheh et al.

Summary: This article introduces an efficient cold-starting energy harvester system, which operates at low voltages and can start up and continue operating at minimum input voltages. The system achieves high power efficiency across a wide range of loading powers.

IEEE JOURNAL OF SOLID-STATE CIRCUITS (2021)

Article Engineering, Electrical & Electronic

Concurrent Potentiometric and Amperometric Sensing With Shared Reference Electrodes

Daryl Ma et al.

Summary: This study investigates the feasibility of simultaneous use of potentiometry and amperometry in a single electrochemical cell, showing high correlation in potentiometric readings with a shared reference electrode and good cross correlation in amperometric sensing. Through innovative test systems, the concurrent measurement for potentiometry in the presence of cell current is successfully demonstrated.

IEEE SENSORS JOURNAL (2021)

Article Chemistry, Multidisciplinary

Biospired Janus Silk E-Textiles with Wet-Thermal Comfort for Highly Efficient Biofluid Monitoring

Xuecheng He et al.

Summary: The study introduces a skin-comfortable Janus electronic textile based on natural silk materials for managing and analyzing biofluid. By utilizing the dual biofluid behavior of the silk substrate and the textile sensing electrode, it achieves a comfortable skin microenvironment and rapid analysis of human sweat targets.

NANO LETTERS (2021)

Article Chemistry, Physical

Giant magnetoelastic effect in soft systems for bioelectronics

Yihao Zhou et al.

Summary: The study found that dispersing micromagnets in a silicone matrix can achieve a highly efficient soft magnetoelastic generator, with a higher magnetomechanical coupling factor than rigid materials. This new type of flexible magnetic material can be used for stretchable, water-resistant magnetoelastic generators that can conform to human skin, opening up a new avenue for human-body-centered applications.

NATURE MATERIALS (2021)

Article Multidisciplinary Sciences

Large-area display textiles integrated with functional systems

Xiang Shi et al.

Summary: Integrating display technology into textiles opens up exciting possibilities for smart electronic textiles, revolutionizing human-machine interactions and providing real-time communication tools for individuals with voice difficulties. This display textile, with its durable, flexible, and breathable design, offers stable brightness even when bent, stretched, or pressed, making it suitable for practical applications in various fields, including healthcare within the Internet of Things. This innovative approach combining electronic devices with textiles is expected to shape the next generation of electronics.

NATURE (2021)

Article Chemistry, Physical

Permeable superelastic liquid-metal fibre mat enables biocompatible and monolithic stretchable electronics

Zhijun Ma et al.

Summary: A new type of stretchable conductor, liquid-metal fiber mat, has been developed with high permeability, stretchability, conductivity, and electrical stability, as well as good biocompatibility and adaptiveness to omnidirectional stretching. The liquid metal self-organizes into mesh-like and buckled structures on an electrospun elastomeric fiber mat, allowing for the realization of highly permeable and multifunctional monolithic stretchable electronics.

NATURE MATERIALS (2021)

Article Chemistry, Physical

Highly stretchable multilayer electronic circuits using biphasic gallium-indium

Shanliangzi Liu et al.

Summary: Biphasic Ga-In, a printable conductor, with high conductivity and extreme stretchability, is used to create various stretchable circuit board assemblies through a scalable transfer-printing process. These assemblies include a multilayer light-emitting diode display, an amplifier circuit, and a signal conditioning board for wearable sensing applications.

NATURE MATERIALS (2021)

Article Chemistry, Analytical

A wearable microfluidics-integrated impedimetric immunosensor based on Ti3C2Tx MXene incorporated laser-burned graphene for noninvasive sweat cortisol detection

Joong San Nah et al.

Summary: A wearable sweat sensor based on MXene and graphene was developed, with a 3D printed microfluidic system for noninvasive cortisol detection in human sweat. The sensor exhibited linear detection with a low limit of 88 pM.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Review Endocrinology & Metabolism

Skin Metabolomics

Decibel P. Elpa et al.

Summary: The skin retains a variety of metabolites that play important physiological roles and can be detected to diagnose and treat diseases. Miniature probes have been developed to detect high-abundance metabolites secreted with sweat, and analysis methods such as chromatography and mass spectrometry are used to study a broad spectrum of skin metabolites.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

Article Multidisciplinary Sciences

A self-sustainable wearable multi-modular E-textile bioenergy microgrid system

Lu Yin et al.

Summary: This study introduces a novel e-textile microgrid system that relies solely on human activity for energy harvesting, showcasing efficient, autonomous, and sustainable design principles for wearable systems.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

A novel device for detecting anaerobic threshold using sweat lactate during exercise

Yuta Seki et al.

Summary: The study successfully visualized the changes in lactate concentration in sweat during exercise using a wearable lactate sensor, showing a strong correlation between sweat LT1, blood LT1, and VT1. Continuous monitoring of lactate concentrations provided additional information for detecting the ventilatory threshold.

SCIENTIFIC REPORTS (2021)

Review Chemistry, Physical

Design, manufacturing and applications of wearable triboelectric nanogenerators

Haobin Wang et al.

Summary: TENGs, as a new wearable technology that can convert low-frequency mechanical energy into electricity, have advantages in capturing human motion energy, driving wearable devices, and extracting output signal information. Wearable TENGs play important roles in the era of smart Internet of Things, mainly used in sensors, actuators, and human-machine interfaces. The technology has made progress in performance and process levels, with concrete prospects to further enter the market and serve the general public.

NANO ENERGY (2021)

Article Multidisciplinary Sciences

Finger sweat analysis enables short interval metabolic biomonitoring in humans

Julia Brunmair et al.

Summary: Metabotyping using sweat from fingertips is a promising noninvasive tool for precision medicine, overcoming limitations of traditional metabolic analysis. Dynamic metabolic patterns can be assessed through sweat sampling, which is repeatable and reliable, enabling the monitoring of individual response to stimuli.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

High-performance wearable thermoelectric generator with self-healing, recycling, and Lego-like reconfiguring capabilities

Wei Ren et al.

Summary: The wearable TEG achieves high open-circuit voltage and flexibility, and greatly improves performance through integrating wavelength-selective metamaterial film, paving the way for the next generation of energy-harvesting devices.

SCIENCE ADVANCES (2021)

Article Materials Science, Multidisciplinary

Printed Iontophoretic-Integrated Wearable Microfluidic Sweat-Sensing Patch for On-Demand Point-Of-Care Sweat Analysis

Brince Paul et al.

Summary: This study presents a printed iontophoretic-integrated fluidic sweat patch for on-demand real-time monitoring of sweat in stationary conditions. The system features a multisensing sensor array with high sensitivity to sodium, potassium, and pH, making it suitable for real-time monitoring of individual health status.

ADVANCED MATERIALS TECHNOLOGIES (2021)

Article Engineering, Biomedical

An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers

Juliane R. Sempionatto et al.

Summary: This study presents a smart skin-worn device that can monitor blood pressure, heart rate, and various biomarkers, allowing for the capture of physiological effects of food intake and exercise.

NATURE BIOMEDICAL ENGINEERING (2021)

Article Chemistry, Multidisciplinary

Touch-Based Stressless Cortisol Sensing

Wanxin Tang et al.

Summary: The new touch-based non-invasive cortisol sensor allows for rapid, simple, and reliable detection of cortisol in sweat, with highly selective binding and direct electrical signaling. Additionally, the use of highly permeable sweat-wicking porous hydrogel enables convenient and rapid collection of instantly secreted fingertip sweat.

ADVANCED MATERIALS (2021)

Article Chemistry, Analytical

Osmotically Enabled Wearable Patch for Sweat Harvesting and Lactate Quantification

Tamoghna Saha et al.

Summary: The newly developed wearable sweat sampling patch combines osmosis and capillary action for long-term sweat withdrawal and management with high accuracy in measuring sweat lactate levels under different conditions. The correlation between lactate levels in sweat and blood is higher during high-intensity exercise, suggesting that sweat is a suitable biofluid for lactate quantification. The wearable patch holds the potential of providing a comprehensive analysis of sweat lactate trends in the human body.

MICROMACHINES (2021)

Review Chemistry, Multidisciplinary

Can Wearable Sweat Lactate Sensors Contribute to Sports Physiology?

Kevin Van Hoovels et al.

Summary: The discussion in the passage revolves around the measurement of lactate content in human sweat using wearable sensors during sports activities, focusing on the potential usefulness and existing issues. It points out contradictory evidence regarding the origin and concentration of sweat lactate, as well as highlighting the importance of accurate detection methods.

ACS SENSORS (2021)

Review Energy & Fuels

Flexible and wearable supercapacitors: A short review

M. M. Atta et al.

Summary: The research on wearable and flexible supercapacitors (FS) in various applications has gained significant attention. Different fabrication methods and materials have been explored to enhance the properties of FS. This review provides a comprehensive overview of recent works on FS, including fabrication routes, active materials, and classification based on flexible materials, serving as a guide for beginners in the field.

JOURNAL OF ENERGY STORAGE (2021)

Article Medicine, Research & Experimental

Integration of Artificial Intelligence, Blockchain, and Wearable Technology for Chronic Disease Management: A New Paradigm in Smart Healthcare

Yi Xie et al.

Summary: Chronic diseases are a global concern, and smart wearable technology, artificial intelligence, and blockchain can enhance chronic disease management models, improve quality of life and patient outcomes, and protect user privacy. A patient-centric technical framework is proposed in the study, exploring the applications of these technologies in chronic disease management.

CURRENT MEDICAL SCIENCE (2021)

Article Biochemistry & Molecular Biology

Hydrogel-based biocontainment of bacteria for continuous sensing and computation

Tzu-Chieh Tang et al.

Summary: A hydrogel-based encapsulation system, known as DEPCOS, has been developed to provide deployable physical containment for genetically modified microorganisms, preventing their escape and protecting them against environmental insults. It also allows for controlled lifespan and easy retrieval of bacteria, showcasing versatility in executing useful functions such as cell-cell communication and heavy metal sensing.

NATURE CHEMICAL BIOLOGY (2021)

Article Cell Biology

Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management

Tyler R. Ray et al.

Summary: Quantitative assessment of chloride concentrations in sweat is crucial for early diagnosis of cystic fibrosis. A new soft, epidermal microfluidic device allows for efficient sweat collection and analysis, with real-time image analysis for quantification using a smartphone camera. This technology has shown clinical equivalence to existing devices and can potentially improve diagnostic capabilities outside clinical settings.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Chemistry, Analytical

ANTIGONE: A Programmable Energy-Efficient Current Digitizer for an ISFET Wearable Sweat Sensing System

Evgenia Voulgari et al.

Summary: This article introduces the design and characterization of the ANTIGONE ASIC, which is energy-efficient and interfaces with multiple ISFET sensors to detect various biomarkers in human sweat. The ASIC system allows for real-time health monitoring and is part of a larger wearable platform integrating multiparameter biosensors and environmental sensors for personalized and preventive healthcare.

SENSORS (2021)

Article Multidisciplinary Sciences

A wearable patch for continuous analysis of thermoregulatory sweat at rest

Hnin Yin Yin Nyein et al.

Summary: The study presents wearable microfluidics-based patches for continuous sweat monitoring at rest, enabling detection of pH, Cl-, and levodopa for dynamic sweat analysis related to routine activities, stress events, hypoglycemia-induced sweating, and Parkinson's disease, thus allowing for continuous and autonomous monitoring of body physiology at rest.

NATURE COMMUNICATIONS (2021)

Article Engineering, Biomedical

Ethical Considerations of Wearable Technologies in Human Research

Jiaobing Tu et al.

Summary: Wearable technologies show great promise in disease diagnosis and patient care, but only a few devices have been commercialized and approved for medical use. There is a gap between current standards and protocols to guide ethical conduct in human research, which may lead to irresponsible behavior by researchers in the field of wearable technologies.

ADVANCED HEALTHCARE MATERIALS (2021)

Review Chemistry, Multidisciplinary

Wearable and Mobile Sensors for Personalized Nutrition

Juliane R. Sempionatto et al.

Summary: Precision nutrition has emerged to tailor nutrition based on individual requirements, aiming at promoting health. Current digital nutrition technology lacks the ability to monitor nutrition at the molecular level, while wearable chemical sensors can bridge this gap. Effective personalized nutrition approaches will require synergy from different sensor modalities.

ACS SENSORS (2021)

Article Chemistry, Multidisciplinary

Touch-Based Fingertip Blood-Free Reliable Glucose Monitoring: Personalized Data Processing for Predicting Blood Glucose Concentrations

Juliane R. Sempionatto et al.

Summary: The study presents a new rapid and reliable approach that combines a simple touch-based fingertip sweat electrochemical sensor with a new algorithm for accurate estimation of blood glucose concentrations. The painless and simple glucose self-testing protocol leverages the fast sweat rate on the fingertip for rapid assays of natural perspiration, without any sweat stimulation, in addition to personalized sweat-response-to-blood concentration translation.

ACS SENSORS (2021)

Article Engineering, Electrical & Electronic

An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time

Kyeongha Kwon et al.

Summary: The platform presented in the study enables real-time monitoring of sweat parameters by combining a short fluid passage and a flow sensor. Data is transferred wirelessly using a Bluetooth Low Energy system on a chip, and it can also integrate with microfluidic systems and colorimetric chemical reagents for multi-parameter measurements.

NATURE ELECTRONICS (2021)

Article Biotechnology & Applied Microbiology

Temporal profiling of cytokines in passively expressed sweat for detection of infection using wearable device

Badrinath Jagannath et al.

Summary: This study demonstrates the potential of using passive sweat for tracking human body's inflammatory response, with the development of a wearable SWEATSENSER device for real-time monitoring of cytokines. The device shows high accuracy and specificity in detecting inflammatory markers, making it a promising tool for noninvasive tracking of host immune response biomarkers.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2021)

Article Biotechnology & Applied Microbiology

Administration of pilocarpine by microneedle patch as a novel method for cystic fibrosis sweat testing

Song Li et al.

Summary: The study investigated the feasibility of using microneedle patches as an alternative to iontophoresis for inducing sweating with pilocarpine. Results showed that the microneedle patches were able to deliver more pilocarpine and induce comparable sweat volume and chloride concentration in sweat compared to iontophoresis, suggesting a simpler and more accessible alternative for diagnosing CF.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2021)

Article Chemistry, Multidisciplinary

Wearable Biosupercapacitor: Harvesting and Storing Energy from Sweat

Jian Lv et al.

Summary: This work presents a novel sweat-based wearable and stretchable biosupercapacitor technology capable of generating high-power pulses from human activity. By leveraging sweat lactate to harvest and store energy, this device offers a promising energy source for the next generation of wearable electronics.

ADVANCED FUNCTIONAL MATERIALS (2021)

Review Chemistry, Multidisciplinary

Pushing the Limits of Flexibility and Stretchability of Solar Cells: A Review

Emilie Dauzon et al.

Summary: Emerging forms of soft, flexible, and stretchable electronics have the potential to revolutionize the future electronics industry, with stretchable photovoltaics as self-powering systems showing great promise for various applications. Current research is focused on achieving wearability and stretchability in electronic systems, utilizing both extrinsic and intrinsic approaches for inducing stretchability.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Cactus-Spine-Inspired Sweat-Collecting Patch for Fast and Continuous Monitoring of Sweat

Jonghyun Son et al.

Summary: A sweat sensor using a sweat-collecting patch efficiently collects sweat and allows for quick response to and continuous monitoring of changes in sweat biochemicals.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

40.1% Record Low-Light Solar-Cell Efficiency by Holistic Trap-Passivation using Micrometer-Thick Perovskite Film

Xilai He et al.

Summary: Perovskite solar cells show high efficiency in both full sunlight and low-light conditions, with a record efficiency of 40.1% achieved under warm LED light. A holistic passivation strategy reduces trap states in both surface and bulk of the perovskite film, resulting in increased charge carrier lifetimes and decreased nonradiative recombination loss. This work paves the way for high-performance, self-powered IoT devices.

ADVANCED MATERIALS (2021)

Review Chemistry, Multidisciplinary

Energy Autonomous Sweat-Based Wearable Systems

Libu Manjakkal et al.

Summary: Research has shown that sweat-based energy generation and storage technologies can provide sustainable and safe power for wearable electronic devices. These technologies have high power and energy densities to meet the energy needs in various applications.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Non-Invasive Sweat-Based Tracking of L-Dopa Pharmacokinetic Profiles Following an Oral Tablet Administration

Jong-Min Moon et al.

Summary: Levodopa is the standard medication for symptomatic therapy of Parkinson's disease, but long-term use may lead to motor and non-motor complications. This study introduces an individualized therapeutic drug monitoring method that tracks the drug concentration in fingertip sweat, demonstrating a personalized dose-response relationship.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Biophysics

Bioelectricity production from sweat-activated germination of bacterial endospores

Jihyun Ryu et al.

Summary: A microbial fuel cell utilizing bacterial spores as a biocatalyst embedded in a skin-mountable device is able to generate electricity through the activation by nutrient-rich human sweat. The potential solution for disposable and long-term storage power source for next-generation wearable applications is demonstrated by the research, showing promise in powering small devices on-demand. The bacterial leakage risk is minimized by packaging with a small pore size paper, ensuring the safety and effectiveness of the device.

BIOSENSORS & BIOELECTRONICS (2021)

Article Computer Science, Hardware & Architecture

A Survey on Wearable Technology: History, State-of-the-Art and Current Challenges

Aleksandr Ometov et al.

Summary: This paper provides an overview of the history and current state of the wearable device market, including a diverse classification and discussion on technologies, architectures, data processing, and market status. It also highlights existing and future solutions to critical challenges in wearable technology.

COMPUTER NETWORKS (2021)

Article Electrochemistry

CATCH (Cortisol Apta WATCH): 'Bio-mimic alarm' to track Anxiety, Stress, Immunity in human sweat

Madhavi Pali et al.

Summary: The study presents an electrochemical sensor platform for detecting cortisol in sweat, allowing for real-time monitoring of cortisol levels and stress conditions in the body.

ELECTROCHIMICA ACTA (2021)

Article Multidisciplinary Sciences

Scalable production of high-performing woven lithium-ion fibre batteries

Jiqing He et al.

Summary: Research has shown that there is a hyperbolic cotangent function relationship between the internal resistance of long fibre lithium-ion batteries and their length, with the resistance decreasing before leveling off as the length of the fibres increases. Through an optimized scalable industrial process, high-performing metre-long fibre lithium-ion batteries with high energy density and cycle stability can be mass-produced. These batteries are able to maintain over 80% capacity even after bending the fibre for 100,000 cycles, and can wirelessly charge devices or power fabric-based electronic components such as a health management jacket with fibre sensors and a textile display.

NATURE (2021)

Article Biotechnology & Applied Microbiology

Wearable materials with embedded synthetic biology sensors for biomolecule detection

Peter Q. Nguyen et al.

Summary: This study demonstrates the development of wearable devices functionalized with freeze-dried, cell-free synthetic circuits for noninvasive detection of biomolecules, including virus nucleic acids, without the need for living engineered bacteria. The technology shows promise for expanding opportunities in physiological status monitoring and disease detection.

NATURE BIOTECHNOLOGY (2021)

Article Multidisciplinary Sciences

Robust, self-adhesive, reinforced polymeric nanofilms enabling gas-permeable dry electrodes for long-term application

Yan Wang et al.

Summary: The study introduces a robust, self-adhesive, gas-permeable nanofilm that can self-adhere to human skin for a week. This nanofilm is capable of supporting liquids 79,000 times heavier than its own weight, with a high tensile stress.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Highly conductive and elastic nanomembrane for skin electronics

Dongjun Jung et al.

Summary: The float assembly method allows for the fabrication of nanomembranes with high conductivity, stretchability, and ultrathin thickness, enabling skin electronics to achieve high elasticity and patterning for multifunctional epidermal sensor arrays.

SCIENCE (2021)

Review Chemistry, Analytical

Energy Solutions for Wearable Sensors: A Review

Guoguang Rong et al.

Summary: Wearable sensors have become popular for providing continuous and real-time physiological information, and various energy sources such as batteries, solar cells, and biofuel cells are used to power these technologies. Each energy source has its own advantages and drawbacks, and researchers should carefully select the appropriate power source to ensure the effectiveness of the devices.

SENSORS (2021)

Article Multidisciplinary Sciences

Glucose-oxidase like catalytic mechanism of noble metal nanozymes

Jinxing Chen et al.

Summary: Gold nanoparticles exhibit enzyme-like activities and can mimic the catalytic process of glucose oxidation enzyme, producing H2O2; other noble metal nanoparticles can also catalyze glucose oxidation reaction, where oxygen is preferably reduced to water.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

PCA-based unsupervised feature extraction for gene expression analysis of COVID-19 patients

Kota Fujisawa et al.

Summary: COVID-19, caused by the SARS-CoV-2 virus, is a global pandemic. A study using a machine learning method identified 123 genes critical for COVID-19 progression, with immune-related genes being enriched. These genes are influenced by NF-κB activity and histone modification, suggesting a potential mechanism of immune suppression in COVID-19 patients.

SCIENTIFIC REPORTS (2021)

Review Engineering, Biomedical

Machine Learning-Reinforced Noninvasive Biosensors for Healthcare

Kaiyi Zhang et al.

Summary: The emergence and development of noninvasive biosensors have greatly facilitated the collection of physiological signals and health-related data. The utilization of machine learning algorithms enhances the accuracy and efficiency of biosensors, leading to significant advances in healthcare applications.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Chemistry, Physical

A flexible and wearable epidermal ethanol biofuel cell for on-body and real-time bioenergy harvesting from human sweat

Mimi Sun et al.

Summary: The study introduces a novel wearable epidermal ethanol biofuel cell for sampling sweat and generating electricity on the skin in real-time. This technology expands the scope of biofuels derived from human sweat, paving the way for real-time bioenergy harvesting.

NANO ENERGY (2021)

Article Chemistry, Multidisciplinary

Lactate Biosensing for Reliable On-Body Sweat Analysis

Xing Xuan et al.

Summary: A novel lactate biosensor with expanded detection range and good performance has been developed by restricting the lactate flux reaching the immobilized enzyme. The biosensor effectively reduces the influence of pH and temperature on the enzyme through an outer plasticized polymeric layer. Rigorous experimentation under strict conditions has been conducted, demonstrating excellent performance.

ACS SENSORS (2021)

Article Multidisciplinary Sciences

Printable elastomeric electrodes with sweat-enhanced conductivity for wearables

Jian Lv et al.

Summary: The research team successfully synthesized a thermoplastic and hydrophilic HPUA binder to create printable and stretchable Ag-HPUA electrodes, enhancing their conductivity with human sweat and reducing resistance. This technology can be utilized in manufacturing batteries and wiring for wearable electronic devices.

SCIENCE ADVANCES (2021)

Article Materials Science, Multidisciplinary

Combining Hydrophilic and Hydrophobic Materials in 3D Printing for Fabricating Microfluidic Devices with Spatial Wettability

Max J. Maennel et al.

Summary: The fabrication of microfluidic flow cells using projection micro-stereolithography (PμSL) allows for precise control of surface properties to create desired flow profiles, such as emulsion droplets. Homemade photopolymer formulations are designed to create either hydrophilic or hydrophobic surfaces, enabling the 3D printing of microchannels with specific wettabilities. By combining these materials, it is possible to fabricate microfluidic flow cells with spatially defined wettability for emulsion formation.

ADVANCED MATERIALS TECHNOLOGIES (2021)

Article Engineering, Biomedical

Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue

Hyunwoo Yuk et al.

Summary: This adhesive paste, inspired by barnacle glue, effectively seals tissues in less than 15 seconds regardless of blood coagulation rate. With a design based on adhesive proteins embedded in a lipid-rich matrix, the paste resorbs slowly over weeks and forms strong interfaces with blood-covered tissues, outperforming commercial haemostatic agents. It may be beneficial in treating severe bleeding, even in individuals with coagulopathies.

NATURE BIOMEDICAL ENGINEERING (2021)

Article Chemistry, Multidisciplinary

Tuning SLOCK toward Chronic Disease Diagnostics and Management: Label-free Sweat Interleukin-31 Detection

Sayali Upasham et al.

Summary: The SLOCK platform is an electrochemical sweat-based biosensing platform designed for the diagnosis and management of circadian abnormalities. This study demonstrates the successful tuning of the platform for the detection of the cytokine IL-31, showing good sensitivity and specificity. The results suggest that the SLOCK biosensor can be used for sensitive and noninvasive tracking of IL-31 in order to identify chronic pathophysiologies.

ACS OMEGA (2021)

Article Chemistry, Physical

A passive perspiration biofuel cell: High energy return on investment

Lu Yin et al.

Summary: This study introduces a touch-based lactate biofuel cell harvester, which leverages the high passive perspiration rate of fingertips for bioenergy harvesting without the need for human movement. In addition, piezoelectric generators are integrated to further scavenge mechanical energy, thus showcasing a practical example of remarkably high energy return on investment for future self-sustainable electronic systems.

JOULE (2021)

Review Chemistry, Multidisciplinary

Laser-engraved graphene for flexible and wearable electronics

Minqiang Wang et al.

Summary: Laser-engraved graphene (LEG) has shown great promise in flexible electronics, with its versatile properties and environmental friendliness. Its technological advances enable LEG to be applied in a wide range of wearable and flexible electronic devices.

TRENDS IN CHEMISTRY (2021)

Article Engineering, Electrical & Electronic

Stretchable transparent electrodes for conformable wearable organic photovoltaic devices

Nan Cui et al.

Summary: Improving the stretchable transparent electrode (STE) is crucial for achieving adhesive and conformable wearable electronics. By using a nonuniform Young's modulus structure with silver nanowire, a highly efficient ultraflexible wearable device was fabricated, enabling energy-harvesting and biomedical-sensing applications.

NPJ FLEXIBLE ELECTRONICS (2021)

Article Materials Science, Multidisciplinary

Flexible, self-healable, adhesive and wearable hydrogel patch for colorimetric sweat detection

Lirong Wang et al.

Summary: Recent advances in wearable sweat sensors have enabled on-demand sweat colorimetric detection for pH, glucose, Cl-, and Ca2+ in human sweat, with great potential for point-of-care devices. This flexible, self-healable, adhesive hydrogel patch shows excellent reliability and stability for measuring multiple sweat biomarkers, converting analyte concentration into RGB digital signals effectively.

JOURNAL OF MATERIALS CHEMISTRY C (2021)

Review Engineering, Electrical & Electronic

Recent Advances in Electrochemical Sensors for Wearable Sweat Monitoring: A Review

Kan Kan Yeung et al.

Summary: This review highlights the recent progress in the development and application of electrochemical sweat sensors and self-powered systems for wearable applications, including various types of sensors and novel functional nanomaterials. The advancement of battery-free wearable devices, such as self-powered biofuel cells and energy harvesting from novel materials, are also discussed, along with the challenges and opportunities in developing sweat sensor-based wearable systems for future directions.

IEEE SENSORS JOURNAL (2021)

Review Engineering, Electrical & Electronic

Recent Progress of Wearable Piezoelectric Nanogenerators

Cong Zhang et al.

Summary: This paper discusses the importance of textile-based PENGs in the development of lightweight energy sources and their relationship with smart textiles and energy conversion. It also summarizes methods to improve their performance and compares the preparation of different device structures.

ACS APPLIED ELECTRONIC MATERIALS (2021)

Article Computer Science, Artificial Intelligence

Machine learning and computation-enabled intelligent sensor design

Zachary Ballard et al.

Summary: This perspective discusses the design of intelligent sensor systems that utilize machine learning to optimize data sensing. By leveraging inverse design and machine learning techniques, data acquisition hardware can be fundamentally redesigned to lock in to the optimal sensing data. This new generation of computational sensing systems aims to reduce data burden and improve sensing capabilities, enabling low-cost and compact sensor implementations with applications in various fields.

NATURE MACHINE INTELLIGENCE (2021)

Article Computer Science, Information Systems

Automatic Detection of COVID-19 Based on Short-Duration Acoustic Smartphone Speech Analysis

Brian Stasak et al.

Summary: This study utilizes machine learning techniques to automatically classify COVID-19 based on acoustic features extracted from speech. Experimental results demonstrate that with specific feature-task combinations and feature selection, classification accuracy of up to 86% can be achieved.

JOURNAL OF HEALTHCARE INFORMATICS RESEARCH (2021)

Review Materials Science, Multidisciplinary

Earth-abundant non-toxic perovskite nanocrystals for solution processed solar cells

Sergio Aina et al.

Summary: Semiconductor nanocrystals, particularly in quantum dot solar cells, offer unique characteristics due to their size- and shape-dependent properties. Quantum dot solar cells, along with perovskite solar cells, have shown impressive progress and potential as alternatives to commercial solar cells. However, the search for non-toxic alternatives remains a challenge in improving efficiency in photovoltaic solar cells.

MATERIALS ADVANCES (2021)

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Summary: Wearable biosensors have the potential to revolutionize personalized healthcare by detecting key physiological indicators. However, these complex devices require suitable power sources. Emerging wearable energy harvesters convert various ambient energy sources into electricity to address the challenges of wearable power supply. When integrated with power management circuits and energy storage devices, these harvesters can power additional biosensors and signal processing electronics.

ACCOUNTS OF MATERIALS RESEARCH (2021)

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A thread/fabric-based band as a flexible and wearable microfluidic device for sweat sensing and monitoring

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Summary: Flexible biosensors have emerged as a promising platform for portable diagnostics, with the potential for in situ point-of-care analytic devices. This study developed a wearable microfluidic thread/fabric-based analytical device for epidermal sweat sensing, enabling precise analysis of local sweat loss, pH, chloride, and glucose concentrations. The device utilizes colorimetric reference markers and smartphone-assisted calibration for accurate data readout and analysis, demonstrating its capability for quantitative detection of multiple biomarkers in sweat.

LAB ON A CHIP (2021)

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Summary: The study demonstrated the detection capabilities of a sweat-based sensing platform using different sensing modalities and evaluated wicking simulations and biorecognition element characterization. The platform showed sensitivity to biomarker concentrations and supported detailed impedance data analysis through electrochemical fitting. Human subject-based studies and mechanical resiliency studies highlighted the flexibility and high sensitivity of the platform.

RSC ADVANCES (2021)

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Summary: This paper explores the diverse applications of aptamers in biosensors, focusing on their binding configurations and signal transduction strategies. Researchers are interested in the potential of aptamers for clinical diagnosis, aiming to enhance sensitivity and detection limits of target determination.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Extended gate field-effect-transistor for sensing cortisol stress hormone

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Summary: A wearable electronic chip that can monitor the circadian rhythm of cortisol in real-time has been developed. The device shows high sensitivity and accuracy in detecting cortisol concentrations in physiological fluid.

COMMUNICATIONS MATERIALS (2021)

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Point-of-use sweat biosensor to track the endocrine-inflammation relationship for chronic disease monitoring

Sayali Upasham et al.

Summary: The hypothalamic-pituitary-adrenal axis plays a key role in maintaining homeostasis and its disturbance during disease affliction leads to imbalanced responses. By monitoring cortisol and TNF-alpha levels through an electrochemical detection system in human sweat, the impact of chronic stress on the body's homeostasis can be comprehensively evaluated. This wearable system is designed for point-of-use chronic disease self-monitoring and management.

FUTURE SCIENCE OA (2021)

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Biofuel powered glucose detection in bodily fluids with an n-type conjugated polymer

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Stretchable fabric generates electric power from woven thermoelectric fibers

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TALANTA (2020)

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Kenjiro Fukuda et al.

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Carbon threads sweat-based supercapacitors for electronic textiles

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Yi-Lang Chen et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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BIOMICROFLUIDICS (2020)

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A. J. Bandodkar et al.

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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SCIENTIFIC REPORTS (2020)

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Alison Gray et al.

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Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides

Csaba Mihalyi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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BIOSENSORS-BASEL (2020)

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LAB ON A CHIP (2020)

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Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities

Sungbong Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Sweat and saliva cortisol response to stress and nutrition factors

Paul Pearlmutter et al.

SCIENTIFIC REPORTS (2020)

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R. A. Potyrailo et al.

FARADAY DISCUSSIONS (2020)

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Tomoyuki Yokota et al.

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SLOCK (sensor for circadian clock): passive sweat-based chronobiology tracker

Sayali Upasham et al.

LAB ON A CHIP (2020)

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Ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels

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LAB ON A CHIP (2020)

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MATTER (2020)

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Sekar Madhu et al.

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Flexible, low volume detection of chronobiology biomarkers from human sweat

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ANALYST (2020)

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ANALYST (2020)

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Investigation of Cortisol Dynamics in Human Sweat Using a Graphene-Based Wireless mHealth System

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MATTER (2020)

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ENERGY & ENVIRONMENTAL SCIENCE (2020)

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Wearable and flexible electronics for continuous molecular monitoring

Yiran Yang et al.

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Xuecheng He et al.

ANALYTICAL CHEMISTRY (2019)

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Noninvasive Diabetes Monitoring through Continuous Analysis of Sweat Using Flow-Through Glucose Biosensor

Elena V. Karpova et al.

ANALYTICAL CHEMISTRY (2019)

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Bio-Integrated Wearable Systems: A Comprehensive Review

Tyler R. Ray et al.

CHEMICAL REVIEWS (2019)

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Review Biotechnology & Applied Microbiology

Accessing analytes in biofluids for peripheral biochemical monitoring

Jason Heikenfeld et al.

NATURE BIOTECHNOLOGY (2019)

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Aptamer-based lateral flow assay for point of care cortisol detection in sweat

Shima Dalirirad et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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BIOSENSORS & BIOELECTRONICS (2019)

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Integrated Transcriptomic and Proteomic Analysis of Human Eccrine Sweat Glands Identifies Missing and Novel Proteins

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MOLECULAR & CELLULAR PROTEOMICS (2019)

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ADVANCED MATERIALS TECHNOLOGIES (2019)

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Sauna, sweat and science II - do we sweat what we drink?

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ISOTOPES IN ENVIRONMENTAL AND HEALTH STUDIES (2019)

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Inkjet-printed stretchable and low voltage synaptic transistor array

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Noninvasive Sweat-Lactate Biosensor Emplsoying a Hydrogel-Based Touch Pad

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A Fully Integrated and Self-Powered Smartwatch for Continuous Sweat Glucose Monitoring

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Bioinspired Janus Textile with Conical Micropores for Human Body Moisture and Thermal Management

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Metabolomic stability of exercise-induced sweat

Sean W. Harshman et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2019)

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NANO LETTERS (2019)

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ACS APPLIED MATERIALS & INTERFACES (2019)

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Synthetic α-L-Threose Nucleic Acids Targeting BcL-2 Show Gene Silencing and in Vivo Antitumor Activity for Cancer Therapy

Fei Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Public, Environmental & Occupational Health

Consequences of chronic diseases and other limitations associated with old age - a scoping review

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BMC PUBLIC HEALTH (2019)

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Dry double-sided tape for adhesion of wet tissues and devices

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Jonathan Sabate del Rio et al.

NATURE NANOTECHNOLOGY (2019)

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Proof of concept for identifying cystic fibrosis from perspiration samples

Zhenpeng Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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A dataset of continuous affect annotations and physiological signals for emotion analysis

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SCIENTIFIC DATA (2019)

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PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES (2019)

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TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

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NATURE BIOMEDICAL ENGINEERING (2019)

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ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Resettable skin interfaced microfluidic sweat collection devices with chemesthetic hydration feedback

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Construction of a flexible electrochemiluminescence platform for sweat detection

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CHEMICAL SCIENCE (2019)

Proceedings Paper Health Care Sciences & Services

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2019 E-HEALTH AND BIOENGINEERING CONFERENCE (EHB) (2019)

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Materials and structural designs of stretchable conductors

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DIGITAL COMMUNICATIONS AND NETWORKS (2019)

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Wearable sensors for monitoring the physiological and biochemical profile of the athlete

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NPJ DIGITAL MEDICINE (2019)

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JOURNAL OF CYSTIC FIBROSIS (2018)

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Journal of Cystic Fibrosis (2018)

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Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes

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LAB ON A CHIP (2018)

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Classification of micro-calcification in mammograms using scalable linear Fisher discriminant analysis

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MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2018)

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Heat transfer and fluid flow characteristics in multistaged Tesla valves

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NUMERICAL HEAT TRANSFER PART A-APPLICATIONS (2018)

Article Biochemistry & Molecular Biology

Effects of stimulation technique, anatomical region, and time on human sweat lipid mediator profiles

Karan Agrawal et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2018)

Article Biochemical Research Methods

Eccrine Sweat as a Biofluid for Profiling Immune Biomarkers

Benjamin A. Katchman et al.

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High-sensitivity ion detection at low voltages with current-driven organic electrochemical transistors

Matteo Ghittorelli et al.

NATURE COMMUNICATIONS (2018)

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INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Article Chemistry, Physical

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ACS ENERGY LETTERS (2018)

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ACS SENSORS (2018)

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Direct metabolite detection with an n-type accumulation mode organic electrochemical transistor

Anna Maria Pappa et al.

SCIENCE ADVANCES (2018)

Review Chemistry, Multidisciplinary

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Review Biochemical Research Methods

Guide to Selecting a Biorecognition Element for Biosensors

Marissa A. Morales et al.

BIOCONJUGATE CHEMISTRY (2018)

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LAB ON A CHIP (2018)

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Sweat in the pathogenesis of atopic dermatitis

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ALLERGOLOGY INTERNATIONAL (2018)

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Chonghe Wang et al.

NATURE BIOMEDICAL ENGINEERING (2018)

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Flexible Superwettable Tapes for On-Site Detection of Heavy Metals

Xuecheng He et al.

ANALYTICAL CHEMISTRY (2018)

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High-power hybrid biofuel cells using layer-by-layer assembled glucose oxidase-coated metallic cotton fibers

Cheong Hoon Kwon et al.

NATURE COMMUNICATIONS (2018)

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Sunil Kumar et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Article Information Science & Library Science

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Kuo-Lun Hsiao et al.

TELEMATICS AND INFORMATICS (2018)

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Anirban Paul et al.

ACS APPLIED NANO MATERIALS (2018)

Review Engineering, Electrical & Electronic

Wearable sweat sensors

Mallika Bariya et al.

NATURE ELECTRONICS (2018)

Article Engineering, Electrical & Electronic

A wearable pH sensor with high sensitivity based on a flexible charge-coupled device

Shogo Nakata et al.

NATURE ELECTRONICS (2018)

Article Chemistry, Multidisciplinary

Sweat-based wearable energy harvesting-storage hybrid textile devices

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ENERGY & ENVIRONMENTAL SCIENCE (2018)

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ADVANCED MATERIALS (2017)

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Advanced Materials for Printed Wearable Electrochemical Devices: A Review

Jayoung Kim et al.

ADVANCED ELECTRONIC MATERIALS (2017)

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Soft, stretchable, high power density electronic skin-based biofuel cells for scavenging energy from human sweat

Amay J. Bandodkar et al.

ENERGY & ENVIRONMENTAL SCIENCE (2017)

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Proteomic and peptidomic analysis of human sweat with emphasis on proteolysis

Yijing Yu et al.

JOURNAL OF PROTEOMICS (2017)

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Paper: A promising material for human-friendly functional wearable electronics

Hao Liu et al.

MATERIALS SCIENCE & ENGINEERING R-REPORTS (2017)

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Printable elastic conductors by in situ formation of silver nanoparticles from silver flakes

Naoji Matsuhisa et al.

NATURE MATERIALS (2017)

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NATURE NANOTECHNOLOGY (2017)

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Synergy of cAMP and calcium signaling pathways in CFTR regulation

Zoltan Bozoky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Biocompatible and totally disintegrable semiconducting polymer for ultrathin and ultralightweight transient electronics

Ting Lei et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform

Sam Emaminejad et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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SENSORS (2017)

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SMALL (2017)

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Electrochemical bioaffinity sensors for salivary biomarkers detection

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TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2017)

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CURRENT PSYCHIATRY REPORTS (2017)

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SCIENTIFIC REPORTS (2017)

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Article Biotechnology & Applied Microbiology

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Liyi Xie et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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NANO ENERGY (2017)

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FRONTIERS IN PEDIATRICS (2017)

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MICROSYSTEMS & NANOENGINEERING (2017)

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A novel organotypic 3D sweat gland model with physiological functionality

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PLOS ONE (2017)

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SCIENTIFIC REPORTS (2017)

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