☆ 4.4 Review

Theranostic Nanoprobes with Aggregation-Induced NIR-II Emission: from Molecular Design to Biomedical Application

CHEMBIOCHEM (2023)

Related references

Note: Only part of the references are listed.
Review Chemistry, Multidisciplinary

The Chemistry of Organic Contrast Agents in the NIR-II Window

Jing Mu et al.

Summary: Optical imaging is a non-invasive method with high resolution and sensitivity. Researchers have focused on developing contrast agents with near-infrared absorption or emission to improve imaging quality. This review summarizes recent advances in organic luminescent and photoacoustic materials and discusses their imaging performance and potential applications.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Article Medicine, Research & Experimental

Platelet–neutrophil hybrid membrane-coated gelatin nanoparticles for enhanced targeting ability and intelligent release in the treatment of non-alcoholic steatohepatitis

Wei Xie et al.

Nanomedicine-Nanotechnology Biology and Medicine (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Biomimetic Nanoparticles Enabled by Cascade Cell Membrane Coating for Direct Cross-Priming of T Cells

Fangjie Chen et al.

Summary: This study utilized cascade cell membrane coating to prepare biomimetic nanoparticles that can manipulate the cross-priming of T cells, leading to strong antitumor immune responses. Combination with clinical anti-programmed death-1 antibodies demonstrated the potential of this approach in enhancing tumor regression and survival rate.

SMALL (2022)

Add to Collection
Article Optics

Orthogonal Aza-BODIPY-BODIPY dyad as heavy-atom free photosensitizer for photo-initiated antibacterial therapy

Dongliang Yang et al.

Summary: A novel halogen-free photosensitizer, NDB, was synthesized in this study. The ROS generation capability of NDB under 730 nm laser illumination was found to be 3-fold higher than that of the commercial ICG, suggesting its potential application in photo-initiated antibacterial therapy.

JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES (2022)

Add to Collection
Article Materials Science, Biomaterials

An erythrocyte membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of breast cancer

Jia-Qian Li et al.

Summary: Nano drug delivery systems using molybdenum disulfide (MoS2) nanosheets camouflaged with red blood cell membrane (RBC membrane) have been developed for tumor therapy. The MoS2-RBC nanocomposites exhibit good stability, biocompatibility, and immune evasion ability. The system shows pH-dependent drug release behavior and the combination of chemotherapy and photothermal therapy is more effective than single therapy. In vivo experiments confirm the accumulation of the carrier materials at the tumor site and the complete inhibition of tumor growth with minimal side effects.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Small-Molecule Fluorophores for Near-Infrared IIb Imaging and Image-Guided Therapy of Vascular Diseases

Yang Li et al.

Summary: Accurate and dynamic visualization of vascular diseases is crucial for preventing further deterioration. This study presents a novel near-infrared fluorophore that enables high-resolution imaging and real-time feedback of therapeutic efficacy. These findings open up new possibilities for vascular-related phenomena and disease assessment.

CCS CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Multimodal Imaging-Guided Photothermal Immunotherapy Based on a Versatile NIR-II Aggregation-Induced Emission Luminogen

Dingyuan Yan et al.

Summary: A versatile theranostic agent, TPA-BT-DPTQ, was designed and prepared for simultaneous fluorescence imaging, photoacoustic imaging, photothermal imaging, and thermal eradication of tumors. The photothermal therapy mediated by TPA-BT-DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of distant tumors. Combining photothermal therapy with a PD-L1 antibody prevents cancer metastasis and recurrence.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Article Engineering, Environmental

Biomimetic neutrophil and macrophage dual membrane-coated nanoplatform with orchestrated tumor-microenvironment responsive capability promotes therapeutic efficacy against glioma

Ying Yin et al.

Summary: This study presents an effective approach for treating malignant glioma based on neutrophil-macrophage hybrid membrane coating nanotechnology. The biomimetic nanoparticle can overcome the blood-brain barrier and target glioma, showing high therapeutic efficacy.

CHEMICAL ENGINEERING JOURNAL (2022)

Add to Collection
Review Chemistry, Inorganic & Nuclear

Low temperature photothermal therapy: Advances and perspectives

Ke Yang et al.

Summary: Photothermal therapy (PTT) is attracting increasing attention due to its high selectivity, non-invasiveness, negligible drug resistance, oxygen independence, and minimal side effects. However, there are still challenges in its clinical application, such as effectively eliminating tumors without damaging surrounding normal tissues, and overcoming cell tolerance to heat.

COORDINATION CHEMISTRY REVIEWS (2022)

Add to Collection
Review Materials Science, Biomaterials

Lymph Node Mapping for Tumor Micrometastasis

Meng Han et al.

Summary: Lymph node mapping is crucial for preventing, prognosing, and treating tumor micrometastasis. Traditional clinical detection methods still have limitations, which drives the development of fluorescent probes. Recent research has focused on newly designed nanoparticles with promising properties for lymph node mapping.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

Add to Collection
Review Chemistry, Analytical

AIE-Active Photosensitizers: Manipulation of Reactive Oxygen Species Generation and Applications in Photodynamic Therapy

Hao Yu et al.

Summary: Photodynamic therapy is a non-invasive approach for tumor elimination that is gaining increasing attention. The development of aggregation-induced emission (AIE) active photosensitizers has opened up new possibilities for overcoming the limitations of traditional photodynamic therapy.

BIOSENSORS-BASEL (2022)

Add to Collection
Article Nanoscience & Nanotechnology

A Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging

Hongyue Lou et al.

Summary: This study reports a novel small molecule NIR-IIb dye and nanoparticle that enable high-quality fluorescence imaging and photothermal therapy in the near-infrared window. The results demonstrate that the nanoprobe can successfully image various tumors and has high photothermal therapy efficacy, indicating its potential for a broad range of biomedical applications.

ACS APPLIED MATERIALS & INTERFACES (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Biomimetic Aggregation-Induced Emission Nanodots with Hitchhiking Function for T Cell-Mediated Cancer Targeting and NIR-II Fluorescence-Guided Mild-Temperature Photothermal Therapy

Xing Yang et al.

Summary: In this study, biomimetic aggregation-induced emission (AIE) photothermal agents with hitchhiking ability (DC@BPBBT dots) were developed by coating the nanoaggregates of the NIR AIE polymeric photothermal agents with dendritic cell (DC) membranes. The DC@BPBBT dots can be hitchhiked on endogenous T cells, leading to enhanced tumor delivery efficiency. Additionally, these dots were found to activate T cells to secrete TNF-alpha, effectively reducing the expression of HSP70 and rendering tumor cells more sensitive to heat.

ADVANCED FUNCTIONAL MATERIALS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

H2O2-Responsive NIR-II AIE Nanobomb for Carbon Monoxide Boosting Low-Temperature Photothermal Therapy

Gongcheng Ma et al.

Summary: Low-temperature photothermal therapy (PTT) is a promising therapeutic strategy, but the expression of heat shock proteins (HSPs) can hinder its efficacy. Researchers have developed a smart nanobomb that can explode in the tumor microenvironment and release carbon monoxide (CO) to inhibit the expression of HSPs, thereby improving the effectiveness of low-temperature PTT.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Article Engineering, Biomedical

Huang a,1, 1, Deliang Wang b, a, d, a, Qiao Jin a, b,**, Ben

Yue Huang et al.

Summary: The development of antibiotics resistance has become a global health issue. Photothermal therapy offers a potential solution for treating multidrug-resistant bacterial infections. In this study, a polymeric luminogen with aggregation-induced emission was synthesized and used as a photothermal agent. The effectiveness of the agent was demonstrated in animal models of infected wounds.

BIOMATERIALS (2022)

Add to Collection
Article Engineering, Biomedical

Recent advances of aggregation-induced emission materials for fluorescence image-guided surgery

Wei He et al.

Summary: This article investigates the application of aggregation-induced emission materials in intraoperative guidance, with a focus on deep tissue penetration ability, high brightness, and targeted strategies for tumor or other pathology. The article outlines representative interdisciplinary achievements and briefly discusses the challenges and future opportunities of AIE materials.

BIOMATERIALS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging

Hanchen Shen et al.

Summary: This article introduces a new NIR-II fluorescence imaging technique, which utilizes the AIE strategy to design a NIR-II dye with high QY. The dye is used for CL and PL resonance energy transfer, achieving high-quality imaging in animal experiments.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Targeted Immunoimaging of Tumor-Associated Macrophages in Orthotopic Glioblastoma by the NIR-IIb Nanoprobes

Hongqin Zhu et al.

Summary: This study reports the development of a fluorescence imaging method using Er-based rare-earth nanoparticles for targeted imaging of M2-type tumor-associated macrophages (TAMs). By optimizing the core-shell structure and shell thickness, the fluorescence signal of the nanoparticles in the second near-infrared (NIR-IIb) range can be significantly enhanced, enabling high-sensitivity in vivo imaging. The nanoparticles functionalized with a targeting peptide show notable specificity in vitro and in vivo experiments, suggesting their potential as a diagnostic tool for assessing the progression and prognosis of glioblastoma.

SMALL (2022)

Add to Collection
Review Engineering, Biomedical

D-A Type NIR-II Organic Molecules: Strategies for the Enhancement Fluorescence Brightness and Applications in NIR-II Fluorescence Imaging-Navigated Photothermal Therapy

Yan Chen et al.

Summary: The article introduces design strategies using organic D-A type molecules to enhance fluorescence brightness and showcases various applications in tissue imaging under NIR-II FI, including PTT and PTT-based combination therapy. Additionally, the current challenges and future development directions of NIR-II organic molecules for NIR-II FI-guided PTT are summarized.

ADVANCED HEALTHCARE MATERIALS (2022)

Add to Collection
Article Engineering, Biomedical

NIR-II and visible fluorescence hybrid imaging-guided surgery via aggregation-induced emission fluorophores cocktails

Xiaoxiao Fan et al.

Summary: Fluorescence imaging-guided surgery is a significant technique for precision surgery. This study proposes a hybrid navigation surgery using NIR-II and visible fluorescence assisted by aggregation-induced emission nanoparticles (AIE NPs). The combination of NIR-II and visible fluorescence allows for deep tissue localization and easy surgical navigation, improving the surgical process.

MATERIALS TODAY BIO (2022)

Add to Collection
Review Pharmacology & Pharmacy

Progress and recent trends in photodynamic therapy with nanoparticles

Kiyon Rhew et al.

Summary: This review discusses the progress and trends in nanoplatform-based photodynamic therapy (PDT) for various cancers and infectious diseases. The combination of nanotechnology and PDT has shown improved therapeutic efficacy and reduced side effects. However, more safety data are needed for these innovative strategies to advance into clinical trials.

JOURNAL OF PHARMACEUTICAL INVESTIGATION (2022)

Add to Collection
Review Pharmacology & Pharmacy

Decorated bacteria and the application in drug delivery

Feng Wu et al.

Summary: The use of living bacteria as therapeutic agents or drug carriers has shown great potential in treating various diseases. However, the fragility of cells and inadequate therapeutic responses are challenges in achieving effective treatment. Surface decoration of bacteria has emerged as a strategy to enhance their resistance to environmental stressors and endow them with additional characteristics. This review systematically introduces the advancements in surface modification technologies for bacteria, with a focus on single-cell surface decoration strategies. The review highlights the applications of surface-decorated bacteria in improving the bioavailability and efficacy of therapeutic agents, as well as targeted drug delivery. The promises and challenges of using surface-decorated bacteria in cancer therapy, intestinal disease treatment, bioimaging, and diagnosis are discussed, with implications for future clinical translation.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Recent advances in drug delivery and targeting to the brain

Bharti Sethi et al.

Summary: The article discusses the blood-brain barrier (BBB) and the challenges in delivering drugs to the brain. Nanomedicine is proposed as a promising approach, with nanoparticles (NPs) carrying specific ligands for controlled drug delivery. The article also summarizes the recent advancements in brain-specific NPs for different pathological conditions and discusses the fundamental properties of brain-targeted NPs.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection
Review Chemistry, Inorganic & Nuclear

2,1,3-Benzothiadiazole derivative AlEgens for smart phototheranostics

Hua Gu et al.

Summary: Light-mediated nano-theranostics (LMNT) is a promising precision medicine technology. The combination of 2,1,3-Benzothiadiazole derivatives (BTDs) and aggregation-induced emission luminogens (AlEgens) shows great potential in LMNT applications. This review focuses on the development of BTDs-AlEgens in terms of molecular design strategy, smart bioimaging, and tumor phototherapy, as well as the correlation between chemical structures, photophysical properties, and phototheranostic outcomes.

COORDINATION CHEMISTRY REVIEWS (2022)

Add to Collection
Article Materials Science, Multidisciplinary

Molecular engineering of AIE luminogens for NIR-II/IIb bioimaging and surgical navigation of lymph nodes

Shanliang Song et al.

Summary: This study conducted molecular engineering to design a near-infrared-II aggregation-induced emission luminogen with ultralong absorption wavelength for lymph node imaging and surgical navigation. Compared with the clinically used indocyanine green, the designed nanoparticles showed longer retention time, higher penetration depth, better signal-to-noise ratio, and greater photostability, enabling fast and accurate navigation of sentinel lymph nodes.

MATTER (2022)

Add to Collection
Article Materials Science, Biomaterials

Halogen-bridged binuclear iridium(iii) complexes with enhanced photodynamic therapeutic effects in mitochondria

Jinxiao Lyu et al.

Summary: This study found that halogen-bridged binuclear iridium complexes exhibited excellent performance in generating O-1(2) and killing tumor cells through inducing apoptosis. By molecular design and modification, the efficiency of photodynamic therapy can be enhanced by replacing the bridging halogen atoms with heavier atoms and targeting the complex in mitochondria.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Molecular Engineering of NIR-II Fluorophores for Improved Biomedical Detection

Zuhai Lei et al.

Summary: The development of fluorophores for the NIR-II window is a significant and vibrant field in chemistry, biology, and engineering, with wavelength, brightness, and stability being crucial factors. Progress has been made in synthesizing D-A-D and D-pi-A fluorophores, as well as constructing off-on and ratiometric probes.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

Wei Zhu et al.

Summary: A novel NIR-emissive zwitterionic luminogen with AIE features was designed and synthesized for cancer phototheranostics, showing excellent performance in NIR-II fluorescence imaging-guided synergistic phototherapy against cancer, due to its long emission wavelength, effective ROS generation, and high photothermal conversion efficiency.

ADVANCED FUNCTIONAL MATERIALS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Bright and Stable NIR-II J-Aggregated AIE Dibodipy-Based Fluorescent Probe for Dynamic In Vivo Bioimaging

Qisong Zhang et al.

Summary: An organic dye emitting in the second near-infrared window with enhanced fluorescence intensity was developed for in vivo bioimaging and biosensing applications, enabling high frame rate imaging.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Chemistry, Multidisciplinary

High-Performance Near-Infrared Aggregation-Induced Emission Luminogen with Mitophagy Regulating Capability for Multimodal Cancer Theranostics

Yue Li et al.

Summary: An NIR fluorophore TACQ with aggregation-induced emission activity was developed for mitochondrial targeting multimodal cancer theranostics. The TACQ exhibited bright NIR emission, high photothermal conversion efficiency, and efficient generation of reactive oxygen species, making it an efficient theranostic agent for NIR fluorescence and photothermal imaging-guided synergistic chemo-photothermal and photodynamic therapy.

ACS NANO (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Heavy-Atom-Free Photosensitizers: From Molecular Design to Applications in the Photodynamic Therapy of Cancer

Van-Nghia Nguyen et al.

Summary: Photodynamic therapy (PDT) has great potential for cancer treatment due to its spatiotemporal selectivity and noninvasive nature, but the lack of ideal photosensitizers hinders its full potential. Developing advanced smart photosensitizers without heavy atoms has shown significant progress in better meeting the clinical requirements of PDT.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Donor/π-Bridge Manipulation for Constructing a Stable NIR-II Aggregation-Induced Emission Luminogen with Balanced Phototheranostic Performance**

Dingyuan Yan et al.

Summary: The study successfully constructed highly stable NIR-II AIEgen DPBTA-DPTQ nanoparticles using benzo[c]thiophene as an electron-rich and bulky donor/π-bridge, achieving acceptable fluorescence quantum yield and excellent photothermal conversion efficiency. DPBTA-DPTQ showed good biocompatibility and efficient photothermal therapeutic effects in in vitro tests, demonstrating potential for photothermal eradication of tumors in mouse models.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Engineering, Biomedical

Self-assembled AIEgen nanoparticles for multiscale NIR-II vascular imaging

Yaxi Li et al.

Summary: In recent decades, research on fluorogens with aggregation-induced emission (AIEgens) has been intensively conducted with a focus on biomedical applications. One efficient strategy involves designing amphiphilic AIEgens that can self-assemble into uniform nanoparticles for high-resolution intravital vascular fluorescence imaging with a significant penetration depth.

BIOMATERIALS (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Thanh Chung Pham et al.

Summary: This review presents a robust strategy for designing photosensitizers for different species, highlighting the importance of organic PSs in photodynamic therapy. While previous studies have focused on nanomaterials and traditional PSs, this review sets out to report recent innovative strategies for developing organic photosensitizers for enhanced PDT, providing detailed examples to offer intuitive and specific insights to readers.

CHEMICAL REVIEWS (2021)

Add to Collection
Article Chemistry, Applied

Unexpected effect of iodine atoms in heptamethine cyanine dyes on the photodynamic eradication of Gram-positive and Gram-negative pathogens

Olga Semenova et al.

Summary: The introduction of iodine atoms into organic dye molecules has been shown to enhance photodynamic therapy efficacy, with mono-iodinated dyes exhibiting the most pronounced phototoxic effect on E. coli and P. aeruginosa. This study synthesized a series of near-IR iodinated cyanine dyes and found that the photodynamic eradication efficacy varies with the number of iodine atoms, with varying effects on different microbial pathogens. Additionally, the presence of a triethylammonium group in the dye molecule affects the photokilling activity of different bacteria species.

DYES AND PIGMENTS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Molecular Engineering of Near-Infrared-II Photosensitizers with Steric-Hindrance Effect for Image-Guided Cancer Photodynamic Therapy

Shuai Gao et al.

Summary: A new type of photosensitizer was designed in this study, capable of emitting fluorescence in the NIR-II window and producing sufficient singlet oxygen. The nanoparticles demonstrated high efficiency in tumor imaging and photodynamic therapy in mice.

ADVANCED FUNCTIONAL MATERIALS (2021)

Add to Collection
Article Nanoscience & Nanotechnology

Encapsulation of NIR-II AIEgens in Virus-like Particles for Bioimaging

Xuehong Min et al.

Summary: The development of organic nanoparticles with NIR-II fluorescence properties, encapsulated in virus-like particles as templates, enables high-quality in vivo imaging and image-guided surgeries, representing a new type of AIE nanoprobes for biomedical imaging.

ACS APPLIED MATERIALS & INTERFACES (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Precise Molecular Engineering of Small Organic Phototheranostic Agents toward Multimodal Imaging-Guided Synergistic Therapy

Zengming Yang et al.

Summary: This study successfully utilized precise molecular engineering to develop organic fluorophores with multimodal imaging-guided synergistic therapy functions, and designed a high-performance phototheranostic agent MeTIC, providing potential clinical design principles for cancer treatment.

ACS NANO (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Biologically Excretable Aggregation-Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine

Zhe Feng et al.

Summary: The newly designed PEGylated AIE (OTPA-BBT) dots with strong absorption, extremely high NIR-II PLQY, and long aliphatic chain design can be excreted from animal bodies. These dots emit bright fluorescence beyond 1100 nm and are used for monitoring cerebral vasculature and gastrointestinal tract, demonstrating biosafety.

ADVANCED MATERIALS (2021)

Add to Collection
Review Multidisciplinary Sciences

Low-Temperature Photothermal Therapy: Strategies and Applications

Xiulin Yi et al.

Summary: This study summarises strategies for achieving low-temperature PTT using nanomaterials, introduces the synthesis, characteristics, and applications of these nanoplatforms, and discusses the synergistic cancer therapeutic effect of combining PTT with other treatment modalities.

RESEARCH (2021)

Add to Collection
Article Engineering, Biomedical

One-for-all phototheranostics: Single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy

Haifei Wen et al.

Summary: This study successfully constructs a versatile theranostic agent with aggregation-induced emission (AIE) characteristics, providing both multimodality imaging and therapy functions. The theranostic agent exhibits good biocompatibility and excellent therapeutic efficacy, making it a promising platform for practical cancer diagnosis and treatment.

BIOMATERIALS (2021)

Add to Collection
Article Engineering, Biomedical

Nanobody modified high-performance AIE photosensitizer nanoparticles for precise photodynamic oral cancer therapy of patient-derived tumor xenograft

Wenbo Wu et al.

Summary: Photodynamic therapy is a promising noninvasive treatment for patients with superficial tumors, with AIEPS5-NPs-NB showing superior 1O2 generation, bright emission, and targeted delivery capabilities in comparison to traditional PS nanoparticles.

BIOMATERIALS (2021)

Add to Collection
Article Engineering, Biomedical

Incorporating spin-orbit coupling promoted functional group into an enhanced electron D-A system: A useful designing concept for fabricating efficient photosensitizer and imaging-guided photodynamic therapy

Zengming Yang et al.

Summary: The study describes the construction of high-performance photosensitizers through engineering, with TaTIC identified as the best candidate for photodynamic therapy due to its superior reactive oxygen species generation and bright near-infrared fluorescence. Encapsulated into nanoparticles, TaTIC exhibited excellent PDT performance in a mouse model, showing great therapeutic potential.

BIOMATERIALS (2021)

Add to Collection
Article Engineering, Biomedical

Starlike polymer brush-based ultrasmall nanoparticles with simultaneously improved NIR-II fluorescence and blood circulation for efficient orthotopic glioblastoma imaging

Shangyu Chen et al.

Summary: The authors developed ultrasmall TQFP-10 NPs with bright NIR-II fluorescence, prolonged blood circulation, and enhanced tumor accumulation for efficient orthotopic GBM imaging. Compared to traditional NPs, TQFP-10 NPs exhibited higher NIR-II fluorescence quantum yield and longer blood circulation half-life, leading to significantly improved tumor-to-normal tissue ratio in GBM imaging.

BIOMATERIALS (2021)

Add to Collection
Review Engineering, Biomedical

Recent Advances in AIEgen-Based Photodynamic Therapy and Immunotherapy

Menglei Zha et al.

Summary: Cancer, a major threat to public health, lacks effective treatments. Photodynamic therapy using photosensitizers to generate ROS for killing cancer cells has emerged as a noninvasive anti-cancer strategy. A new class of photosensitizers with aggregation-induced emission (AIE) character shows promise for enhancing PDT efficacy.

ADVANCED HEALTHCARE MATERIALS (2021)

Add to Collection
Article Engineering, Biomedical

A two-in-one Janus NIR-II AIEgen with balanced absorption and emission for image-guided precision surgery

S. Liu et al.

Summary: This study proposed a method for designing Janus NIR-II fluorophores by incorporating different electronic donors into one molecule, resulting in balanced absorption and emission properties in fluorescent dyes. The approach combines the advantages of intense absorption from planar architecture and high fluorescence quantum yield from twisted motif.

MATERIALS TODAY BIO (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Aggregation-induced emission fluorophores based on strong electron-acceptor 2,2′-(anthracene-9,10-diylidene) dimalononitrile for biological imaging in the NIR-II window

Zhicheng Yang et al.

Summary: In this study, three novel donor-acceptor-donor type second near-infrared AIE fluorophores based on strong electron-acceptor have been successfully developed for bioimaging. These fluorophores exhibit good photostability and high resolution for mouse ear vessel imaging after encapsulation in nanoparticles with good biocompatibility.

CHEMICAL COMMUNICATIONS (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

Xueze Zhao et al.

Summary: This review summarizes recent progress in developing photosensitizers (PSs) for photodynamic therapy, including enhanced tolerance, improved selectivity, and deep tissue applicability. PSs are classified based on molecular design and application, with strategies for designing and future perspectives briefly outlined.

CHEMICAL SOCIETY REVIEWS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

An easily synthesized AIE luminogen for lipid droplet-specific super-resolution imaging and two-photon imaging

Yanzi Xu et al.

Summary: An imaging platform of DTPA-BT-M with aggregation-induced emission (AIE) characteristics was developed for lipid droplets (LDs)-specific super-resolution cellular imaging and deep-penetrated tissue imaging. DTPA-BT-M showed superior fluorescence properties and a high photoluminescence quantum yield, allowing for ultra-high resolution imaging of LDs via STED nanoscopy and deep tissue penetration in BALB/C nude mice lung tissue via TPF microscopy.

MATERIALS CHEMISTRY FRONTIERS (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Nanoprobes with aggregation-induced emission for theranostics

Wenbo Wu et al.

Summary: Theranostics integrates diagnosis and therapy, reducing side effects and saving time and cost. AIE NPs have shown superior performance in theranostic applications, especially in designing multifunctional AIE molecules for phototherapy.

MATERIALS CHEMISTRY FRONTIERS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging

Zhe Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Add to Collection
Article Engineering, Biomedical

High performance one-for-all phototheranostics: NIR-II fluorescence imaging guided mitochondria-targeting phototherapy with a single-dose injection and 808 nm laser irradiation

Qi Wang et al.

BIOMATERIALS (2020)

Add to Collection
Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Exploring BODIPY Derivatives as Singlet Oxygen Photosensitizers for PDT

Ruth Prieto-Montero et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Fluoro-Photoacoustic Polymeric Renal Reporter for Real-Time Dual Imaging of Acute Kidney Injury

Penghui Cheng et al.

ADVANCED MATERIALS (2020)

Add to Collection
Article Multidisciplinary Sciences

Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Yuanyuan Li et al.

NATURE COMMUNICATIONS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

An All-Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging-Guided Synergistic Therapy

Zhijun Zhang et al.

ADVANCED MATERIALS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics

Guanjun Deng et al.

ACS NANO (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Incorporation of Planar Blocks into Twisted Skeletons: Boosting Brightness of Fluorophores for Bioimaging beyond 1500 Nanometer

Shunjie Liu et al.

ACS NANO (2020)

Add to Collection
Article Chemistry, Multidisciplinary

An NIR-II-Emissive Photosensitizer for Hypoxia-Tolerant Photodynamic Theranostics

Lanqing Li et al.

ADVANCED MATERIALS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

HClO-Activated Fluorescence and Photosensitization from an AIE Nanoprobe for Image-Guided Bacterial Ablation in Phagocytes

Min Wu et al.

ADVANCED MATERIALS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Planar and Twisted Molecular Structure Leads to the High Brightness of Semiconducting Polymer Nanoparticles for NIR-IIa Fluorescence Imaging

Shunjie Liu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection
Review Chemistry, Multidisciplinary

Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

Chunyan Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection
Review Chemistry, Multidisciplinary

Aggregation-enhanced theranostics: AIE sparkles in biomedical field

Miaomiao Kang et al.

AGGREGATE (2020)

Add to Collection
Article Polymer Science

Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics

Jaleesa Bresseleers et al.

POLYMERS (2020)

Add to Collection
Article Materials Science, Multidisciplinary

Making the Best Use of Excited-State Energy: Multimodality Theranostic Systems Based on Second Near-Infrared (NIR-II) Aggregation-Induced Emission Luminogens (AIEgens)

Wenhan Xu et al.

ACS MATERIALS LETTERS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Molecular engineering of a high quantum yield NIR-II molecular fluorophore with aggregation-induced emission (AIE) characteristics for in vivo imaging

Pengfei Xu et al.

NANOSCALE (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm

Yang Li et al.

CHEMICAL SCIENCE (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Molecular engineering of D-A-D conjugated small molecule nanoparticles for high performance NIR-II photothermal therapy

Wei Shao et al.

MATERIALS HORIZONS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Molecular Engineering of an Organic NIR-II Fluorophore with Aggregation-Induced Emission Characteristics for In Vivo Imaging

Wei Wu et al.

SMALL (2019)

Add to Collection
Article Nanoscience & Nanotechnology

Photostable Iridium(III)-Cyanine Complex Nanoparticles for Photoacoustic Imaging Guided Near-Infrared Photodynamic Therapy in Vivo

Qi Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Add to Collection
Article Materials Science, Multidisciplinary

Quaternary Ammonium Salt Based NIR-II Probes for In Vivo Imaging

Chunrong Qu et al.

ADVANCED OPTICAL MATERIALS (2019)

Add to Collection
Article Multidisciplinary Sciences

Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics

Shuai Gao et al.

NATURE COMMUNICATIONS (2019)

Add to Collection
Article Biophysics

Towards biocompatible NIR-II nanoprobes - transfer of hydrophobic Ag2S quantum dots to aqueous solutions using phase transfer catalysed hydrolysis of poly(maleic anhydride-alt-1-octadecene)

Grzegorz Rotko et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Graphene-Oxide-Modified Lanthanide Nanoprobes for Tumor-Targeted Visible/NIR-II Luminescence Imaging

Xiaorong Song et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Boosting Fluorescence-Photoacoustic-Raman Properties in One Fluorophore for Precise Cancer Surgery

Ji Qi et al.

CHEM (2019)

Add to Collection
Review Materials Science, Multidisciplinary

A New Generation of NIR-II Probes: Lanthanide-Based Nanocrystals for Bioimaging and Biosensing

Yong Fan et al.

ADVANCED OPTICAL MATERIALS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Solvent Magic for Organic Particles

Bing Guo et al.

ACS NANO (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Direct visualization of the ouzo zone through aggregation-induced dye emission for the synthesis of highly monodispersed polymeric nanoparticles

Eshu Middha et al.

MATERIALS CHEMISTRY FRONTIERS (2019)

Add to Collection
Article Materials Science, Multidisciplinary

Development of Polyene-Bridged Hybrid Rhodamine Fluorophores for High-Resolution NIR-II Imaging

Yibing Shi et al.

ACS MATERIALS LETTERS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Bright Aggregation-Induced-Emission Dots for Targeted Synergetic NIR-II Fluorescence and NIR-I Photoacoustic Imaging of Orthotopic Brain Tumors

Zonghai Sheng et al.

ADVANCED MATERIALS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Designing Efficient and Ultralong Pure Organic Room-Temperature Phosphorescent Materials by Structural Isomerism

Yu Xiong et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Local structural motifs in proteins: Detection and characterization of fragments inserted in helices

Nicole Balasco et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Polymerization-Enhanced Photosensitization

Wenbo Wu et al.

CHEM (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy

Nuernisha Alifu et al.

ACS NANO (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Multifunctional Liposome: A Bright AIEgen-Lipid Conjugate with Strong Photosensitization

Xiaolei Cai et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection
Review Materials Science, Biomaterials

Single-walled carbon nanotubes as optical probes for bio-sensing and imaging

Jing Pan et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

Add to Collection
Review Engineering, Biomedical

Near-infrared fluorophores for biomedical imaging

Guosong Hong et al.

NATURE BIOMEDICAL ENGINEERING (2017)

Add to Collection
Article Chemistry, Multidisciplinary

Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage

Xiaolei Cai et al.

ADVANCED MATERIALS (2016)

Add to Collection
Article Engineering, Biomedical

In vivo real-time visualization of mesenchymal stem cells tropism for cutaneous regeneration using NIR-II fluorescence imaging

Guangcun Chen et al.

BIOMATERIALS (2015)

Add to Collection
Article Chemistry, Physical

Biological imaging without autofluorescence in the second near-infrared region

Shuo Diao et al.

NANO RESEARCH (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics

Shidang Xu et al.

CHEMICAL SCIENCE (2015)

Add to Collection
Article Chemistry, Physical

Rational design of tetraphenylethylene-based luminescent down-shifting molecules: photophysical studies and photovoltaic applications in a CdTe solar cell from small to large units

Yilin Li et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2014)

Add to Collection
Article Materials Science, Biomaterials

Aggregation induced emission-based fluorescent nanoparticles: fabrication methodologies and biomedical applications

Xiqi Zhang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2014)

Add to Collection
Review Chemistry, Multidisciplinary

Triplet photosensitizers: from molecular design to applications

Jianzhang Zhao et al.

CHEMICAL SOCIETY REVIEWS (2013)

Add to Collection
Article Multidisciplinary Sciences

Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing

Kai Li et al.

SCIENTIFIC REPORTS (2013)

Add to Collection
Article Biochemistry & Molecular Biology

Multifunctional in vivo vascular imaging using near-infrared II fluorescence

Guosong Hong et al.

NATURE MEDICINE (2012)

Add to Collection
Article Chemistry, Multidisciplinary

Full emission color tuning in luminogens constructed from tetraphenylethene, benzo-2,1,3-thiadiazole and thiophene building blocks

Zujin Zhao et al.

CHEMICAL COMMUNICATIONS (2011)

Add to Collection
Review Chemistry, Multidisciplinary

Near-Infrared Organic Compounds and Emerging Applications

Gang Qian et al.

CHEMISTRY-AN ASIAN JOURNAL (2010)

Add to Collection
Review Biochemistry & Molecular Biology

Photodynamic therapy (PDT): A short review on cellular mechanisms and cancer research applications for PDT

C. A. Robertson et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2009)

Add to Collection
Article Nanoscience & Nanotechnology

A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice

Kevin Welsher et al.

NATURE NANOTECHNOLOGY (2009)

Add to Collection
News Item Nanoscience & Nanotechnology

BIOIMAGING Second window for in vivo imaging

Andrew M. Smith et al.

NATURE NANOTECHNOLOGY (2009)

Add to Collection
Article Oncology

Thermal ablation and high-temperature thermal therapy: Overview of technology and clinical implementation

CJ Diederich

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2005)

Add to Collection
Article Chemistry, Multidisciplinary

Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole

JD Luo et al.

CHEMICAL COMMUNICATIONS (2001)

Add to Collection
Article Chemistry, Multidisciplinary

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

H Maeda et al.

JOURNAL OF CONTROLLED RELEASE (2000)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.