Mapping cross-species connectome atlas of human and macaque striatum

Cross-species connectome atlas (CCA) that can provide connectionally homogeneous and homologous brain nodes is essential and customized for cross-species neuroscience. However, existing CCAs were flawed in design and coarse-grained in results. In this study, a normative mapping framework of CCA was proposed and applied on human and macaque striatum. Specifically, all striatal voxels in the 2 species were mixed together and classified based on their represented and characterized feature of within-striatum resting-state functional connectivity, which was shared between the species. Six pairs of striatal parcels in these species were delineated in both hemispheres. Furthermore, this striatal parcellation was demonstrated by the best-matched whole-brain functional and structural connectivity between interspecies corresponding subregions. Besides, detailed interspecies differences in whole-brain multimodal connectivities and involved brain functions of these subregions were described to flesh out this CCA of striatum. In particular, this flexible and scalable mapping framework enables reliable construction of CCA of the whole brain, which would enable reliable findings in future cross-species research and advance our understandings into how the human brain works.

Automated summary

This study proposes a normative mapping framework for a cross-species connectome atlas (CCA) and applies it to the human and macaque striatum. By classifying striatal voxels based on their shared within-striatum resting-state functional connectivity, six corresponding striatal parcels are delineated in both species. The study also demonstrates the best-matched whole-brain connectivity between interspecies corresponding regions and describes interspecies differences in whole-brain multimodal connectivities and brain functions.