4.7 Review

MicroRNA regulation of phenotypic transformations in vascular smooth muscle: relevance to vascular remodeling

Related references

Note: Only part of the references are listed.
Article Hematology

CircRNA circCOL1A1 Acts as a Sponge of miR-30a-5p to Promote Vascular Smooth Cell Phenotype Switch through Regulation of Smad1 Expression

Meng Ye et al.

Summary: The noncoding circular RNA circCOL1A1, transcribed by the COL1A1 gene, is upregulated during the switch of vascular smooth muscle cells (VSMCs) from the contractile to the synthetic phenotype. Through competition with miR-30a-5p, circCOL1A1 promotes VSMC phenotype switch by alleviating the inhibitory effect of miR-30a-5p on its target SMAD1, thereby suppressing transforming growth factor-beta (TGF-beta) signaling. CircCOL1A1 may serve as a novel marker or therapeutic target for atherosclerosis.

THROMBOSIS AND HAEMOSTASIS (2023)

Article Cardiac & Cardiovascular Systems

LncRNA SENCR overexpression attenuated the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection via the miR-206/myocardin axis

Yi Song et al.

Summary: This study found that SENCR inhibits vascular smooth muscle cell proliferation, migration, and synthetic phenotype-related gene expression in aortic dissection through the miR-206/myocardin axis, thereby maintaining the contractile phenotype and suppressing aortic dilatation.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2022)

Article Medicine, General & Internal

Long non-coding RNA LINC00299 knockdown inhibits ox-LDL-induced T/G HA-VSMC injury by regulating miR-135a-5p/XBP1 axis in atherosclerosis

Ming Chang et al.

Summary: This study revealed the regulatory function of LINC00299/miR-135a-5p/XBP1 axis in AS development and proposed a potential therapeutic strategy for AS treatment.

PANMINERVA MEDICA (2022)

Article Cell Biology

CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease

Yuan Liu et al.

Summary: Moyamoya disease (MMD) is a chronic cerebrovascular disease with unknown etiology and pathophysiological changes. The circZXDC-miR-125a-3p-ABCC6 axis plays a pivotal role in the progression of MMD.

CELLS (2022)

Article Cardiac & Cardiovascular Systems

LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin

Junyi Yu et al.

Summary: This study identifies a VSMC-enriched long noncoding RNA called phenotype switching regulator (PSR) and its encoded protein arteridin as important regulators in VSMC phenotype switching and vascular remodeling. They interact with transcription factor YBX1 to modulate transcriptional reprogramming and could be potential therapeutic targets for VSMC phenotype switching-related vascular remodeling.

CIRCULATION RESEARCH (2022)

Article Cell Biology

The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis

Shulan Pi et al.

Summary: The P2RY12 receptor plays a crucial role in regulating macrophagy and VSMC-derived foam cell formation in advanced atherosclerosis, by inhibiting cholesterol efflux and blocking autophagy pathways. Inhibition of the P2RY12 receptor may be a potential therapeutic target for treating atherosclerosis.

AUTOPHAGY (2021)

Article Cell Biology

Suppression of miR-4463 promotes phenotypic switching in VSMCs treated with Ox-LDL

Xueqin Wang et al.

Summary: This study demonstrated that miR-4463 is a novel regulator of VSMC function under hypoxic conditions, modulating VSMC phenotypic switching via the JNK and ERK signaling pathways. Downregulation of miR-4463 enhances VSMC migration and phenotypic transformation, with bFGF potentially being the target gene of miR-4463.

CELL AND TISSUE RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis

Mandy O. J. Grootaert et al.

Summary: The study reveals that SIRT6 protein expression in VSMCs is reduced in human and mouse plaque VSMCs and is positively regulated by CHIP. SIRT6 plays a role in regulating telomere maintenance and VSMC lifespan, inhibiting atherosclerosis through its deacetylase activity.

CIRCULATION RESEARCH (2021)

Article Medical Laboratory Technology

Role of Kruppel-like factor 4 in atherosclerosis

Chen Yang et al.

Summary: KLF4 plays a crucial role in atherosclerosis, regulating foam cell formation, vascular smooth muscle cells phenotypic transformation, and other important processes.

CLINICA CHIMICA ACTA (2021)

Article Cardiac & Cardiovascular Systems

CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin

Kunzhe Dong et al.

Summary: CARMN is a highly conserved SMC-specific long noncoding RNA that plays a crucial role in maintaining the contractile phenotype of VSMCs, and it is the first noncoding RNA discovered to interact with myocardin.

CIRCULATION (2021)

Article Cardiac & Cardiovascular Systems

Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells

Yiming Liu et al.

Summary: Circular RNA circ-FNDC3B is highly expressed in VSMCs and AAA tissues, and its silencing can ameliorate cytotoxicity triggered by Ang-II at least partially depending on the regulation of the miR-143-3p/ADAM10 axis.

INTERNATIONAL HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm

Jorge Oller et al.

Summary: Mitochondrial dysfunction is a hallmark of aortic aneurysm disease in Marfan syndrome, and boosting mitochondrial function through enhancing Tfam levels shows promise as a potential therapeutic strategy for managing aortic aneurysms.

CIRCULATION (2021)

Article Biochemistry & Molecular Biology

MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation

Jingyu Wang et al.

Summary: Atherosclerosis, a chronic inflammatory disease and leading cause of death worldwide, has been linked to dysregulation of microRNAs (miRNAs). In this study, miR-520c-3p was found to reduce atherosclerotic plaque size and collagen content, and inhibit proliferation and migration of VSMCs by targeting RelA/p65, indicating a potential therapeutic strategy for atherosclerosis.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

Article Pharmacology & Pharmacy

Osteogenic differentiation and calcification of human aortic smooth muscle cells is induced by the RCN2/STAT3/miR-155-5p feedback loop

Jian Zhao et al.

Summary: This study reveals that RCN2 is a crucial regulator of vascular calcification under hyperphosphatemic conditions, promoting osteogenic differentiation and calcification of HASMCs by inducing STAT3 phosphorylation. Moreover, a feedback loop involving RCN2/STAT3/miR-155-5p plays an important role in vascular calcification, suggesting that targeting this feedback loop may potentially reverse high phosphate-induced VC.

VASCULAR PHARMACOLOGY (2021)

Article Endocrinology & Metabolism

miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers

Marycarmen Arevalo-Martinez et al.

Summary: The study found that miR-126 plays a crucial role in the metabolic memory of T2DM patients' VSMCs, enhancing the efficacy of Kv1.3 blockers in preventing restenosis by activating the MEK/ERK pathway.

MOLECULAR METABOLISM (2021)

Article Cardiac & Cardiovascular Systems

MiR-4787-5p Regulates Vascular Smooth Muscle Cell Apoptosis by Targeting PKD1 and Inhibiting the PI3K/Akt/FKHR Pathway

Lei Wang et al.

Summary: This study highlighted the crucial role of miR-4787-5p in the pathobiology of aortic dissection (AD) by regulating vascular smooth muscle cell (VSMC) apoptosis. It was found that miR-4787-5p targets PC1 gene in VSMCs to induce apoptosis, and also deactivates the PI3K/Akt/FKHR signaling pathway.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2021)

Review Cell Biology

MicroRNA-mediated regulation of glucose and lipid metabolism

Pamela Agbu et al.

Summary: MicroRNAs play a crucial role in regulating systemic metabolism, particularly glucose and lipid metabolism, and their misexpression can lead to metabolic diseases. They are emerging as potential therapeutic targets and metabolic biomarkers.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Review Engineering, Biomedical

Vascular Mechanobiology: Homeostasis, Adaptation, and Disease

Jay D. Humphrey et al.

Summary: Cells in the vascular wall are highly sensitive to mechanical changes. In healthy arteries, mechanical forces regulate signaling and gene expression for vessel wall remodeling, but diseases often involve maladaptive remodeling and compromised homeostatic mechanisms. Disease progression is characterized by positive feedback loops that generate mechanobiological instabilities, ultimately overriding homeostatic pathways.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021 (2021)

Article Cardiac & Cardiovascular Systems

The miR-182/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-β-signalling pathways in an SMC/EC-crosstalk-associated manner

Yongyi Bai et al.

Summary: The study identified oncologic miR-182 as a new regulator of pulmonary artery hypertension (PAH) targeting Myadm, and suggested that the balance between the BMP and TGF-beta signalling pathways is disrupted in PAH. Hypoxia triggers pathological progression in PAH by downregulating BMP/SMAD1/5/8 expression and enhancing TGF-beta/SMAD2/3 signalling pathway. miR-182 gain-of-function inhibits the progression in PAH, while loss-of-function increases the pathological progression. The study also indicated a crosstalk between endothelial cells and smooth muscle cells in the BMP-TGF-beta pathway associated with NOS3/NO/cGMP.

BASIC RESEARCH IN CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis

Joseph M. Miano et al.

Summary: Studying the phenotypic modulation of vascular smooth muscle cells is crucial for understanding the pathogenesis of atherosclerosis and developing new therapies. Recent technological and conceptual advances shed light on the multifunctionality and plasticity of VSMCs.

CIRCULATION (2021)

Review Biochemistry & Molecular Biology

The Expanding Role of Alternative Splicing in Vascular Smooth Muscle Cell Plasticity

Immanuel D. Green et al.

Summary: Vascular smooth muscle cells (VSMCs) exhibit remarkable phenotypic plasticity, allowing them to differentiate or dedifferentiate based on environmental cues. Alternative splicing plays a crucial role in VSMC gene expression regulation, contributing to protein diversity and alterations in gene expression levels. Recent advancements in splicing-modulating therapies hold promise for treating VSMC-related pathologies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

MicroRNAs: The Link between the Metabolic Syndrome and Oncogenesis

Adriana Fodor et al.

Summary: MetS is a complex entity that increases the risk of various diseases, including type two diabetes, cardiovascular diseases, and certain types of cancer. miRNAs play an important role in cancer genesis, progression, and metastasis, and the altered secretion of miRs in adipose tissue may explain their involvement in oncogenesis. The interaction between miRs expressed in adipose tissue, their dysregulation, and cancer pathogenesis are still intriguing, as miRNAs exhibit both carcinogenic and tumor suppressor effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Cellular Crosstalk between Endothelial and Smooth Muscle Cells in Vascular Wall Remodeling

Nerea Mendez-Barbero et al.

Summary: Pathological vascular wall remodeling refers to the changes in structure and function of the vessel wall in response to injury, potentially leading to cardiovascular disease. Communication between endothelial cells and vascular smooth muscle cells is crucial for vasculature development and vessel homeostasis, with aberrant communication associated with various disease states including vascular wall remodeling. Different mechanisms such as paracrine regulations and direct contact play a role in this interplay.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Circ_0002984 induces proliferation, migration and inflammation response of VSMCs induced by ox-LDL through miR-326-3p/VAMP3 axis in atherosclerosis

Ruogu Li et al.

Summary: In this study, circ_0002984 was found to be up-regulated in atherosclerosis patients and ox-LDL-incubated VSMCs, leading to suppression of VSMC viability, cell cycle distribution, and migration capacity, as well as inhibition of inflammation. Circ_0002984 was shown to modulate cell proliferation, migration, and inflammation in VSMCs by regulating miR-326-3p and VAMP3, suggesting its potential as a therapeutic strategy for atherosclerosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Review Pharmacology & Pharmacy

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

Suowen Xu et al.

Summary: The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in maintaining multiorgan health and homeostasis. Dysfunction of the vascular endothelium is associated with various diseases and is implicated in severe coronavirus disease 2019. Therapeutic approaches targeting endothelial dysfunction may have potential for treatment of cardiovascular and many other diseases.

PHARMACOLOGICAL REVIEWS (2021)

Review Cell Biology

Ferroptosis: the potential value target in atherosclerosis

Siyu Ouyang et al.

Summary: Cell death plays a crucial role in atherosclerosis, with ferroptosis accelerating endothelial dysfunction. Disordered intracellular iron damages various cell types and affects lipid peroxidation, oxidative stress, inflammation, and dyslipidemia in AS. The exact mechanisms through which ferroptosis initiates AS development and progression remain unclear.

CELL DEATH & DISEASE (2021)

Article Multidisciplinary Sciences

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

Qing Zhang et al.

Summary: This study summarized natural compounds that exert protective effects against oxidative stress in vascular endothelial cells (ECs), including phenylpropanoids, flavonoids, terpenoids, and alkaloids. These compounds alleviate EC apoptosis by activating the Nrf2/HO-1 signaling pathway, showing potential for the treatment of atherosclerosis.

JOURNAL OF ADVANCED RESEARCH (2021)

Article Biochemistry & Molecular Biology

miR-31-5p Promotes Oxidative Stress and Vascular Smooth Muscle Cell Migration in Spontaneously Hypertensive Rats via Inhibiting FNDC5 Expression

Bing Zhou et al.

Summary: miR-31-5p plays a crucial role in oxidative stress and VSMC migration by inhibiting FNDC5 expression, leading to increased oxidative stress and cell migration in SHR. The imbalance of miR-31-5p and FNDC5 exacerbates oxidative stress and cell migration in vascular smooth muscle cells.

BIOMEDICINES (2021)

Article Cardiac & Cardiovascular Systems

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

Jorg Taubel et al.

Summary: The study evaluated the safety and mechanism of action of CDR132L in patients with chronic ischemic heart failure, showing that CDR132L is safe and well tolerated, effectively reducing miR-132 levels and improving cardiac function.

EUROPEAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

Jorg Taubel et al.

Summary: The first-in-class miR-132 inhibitor, CDR132L, showed good safety and tolerability in HF patients. It effectively reduced miR-132 levels, decreased NT-proBNP levels, and potentially improved cardiac function.

EUROPEAN HEART JOURNAL (2021)

Review Medicine, Research & Experimental

New insights into phenotypic switching of VSMCs induced by hyperhomocysteinemia: Role of endothelin-1 signaling

Yulong Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Biochemistry & Molecular Biology

The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation

Anastasia Poznyak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cardiac & Cardiovascular Systems

Reduced stiffness and augmented traction force in type 2 diabetic coronary microvascular smooth muscle

Patricia E. McCallinhart et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

miR-128-3p Is a Novel Regulator of Vascular Smooth Muscle Cell Phenotypic Switch and Vascular Diseases

Floriana Maria Farina et al.

CIRCULATION RESEARCH (2020)

Article Cardiac & Cardiovascular Systems

Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype

Kehui Yang et al.

EUROPEAN HEART JOURNAL (2020)

Review Cell Biology

miRNAs, oxidative stress, and cancer: A comprehensive and updated review

Seyed Omar Ebrahimi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

Dihydroartemisinin alleviates high glucose-induced vascular smooth muscle cells proliferation and inflammation by depressing the miR-376b-3p/KLF15 pathway

Bingqi Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration

Nanju Park et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease

Wojciech Ornatowski et al.

REDOX BIOLOGY (2020)

Review Cell Biology

The multifaceted roles of microRNAs in differentiation

Himani Galagali et al.

CURRENT OPINION IN CELL BIOLOGY (2020)

Article Medicine, Research & Experimental

Long Non-coding RNA PEBP1P2 Suppresses Proliferative VSMCs Phenotypic Switching and Proliferation in Atherosclerosis

Xingqiang He et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Article Medicine, Research & Experimental

Involved in Differentiation and Survival of Vascular Smooth Muscle Cells

Yeong-Hwan Lim et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Review Medicine, Research & Experimental

Type H blood vessels in bone modeling and remodeling

Yi Peng et al.

THERANOSTICS (2020)

Article Biochemistry & Molecular Biology

Hypoxia-induced miR-1260b regulates vascular smooth muscle cell proliferation by targeting GDF11

Minhyeong Seong et al.

BMB REPORTS (2020)

Article Cardiac & Cardiovascular Systems

MiR-26b Suppresses the Development of Stanford Type A Aortic Dissection by Regulating HMGA2 and TGF-β/Smad3 Signaling Pathway

Ping Yang et al.

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY (2020)

Article Medicine, Research & Experimental

Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair

Zhi Zeng et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Genetics & Heredity

MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling

Charlene Watterston et al.

PLOS GENETICS (2019)

Article Biochemistry & Molecular Biology

MicroRNA (miRNA)-to-miRNA Regulation of Programmed Cell Death 4 (PDCD4)

Pamela Ajuyah et al.

MOLECULAR AND CELLULAR BIOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Vascular smooth muscle cells in atherosclerosis

Gemma L. Basatemur et al.

NATURE REVIEWS CARDIOLOGY (2019)

Article Biochemistry & Molecular Biology

Perivascular adipose tissue-derived extracellular vesicle miR-221-3p mediates vascular remodeling

Xinzhi Li et al.

FASEB JOURNAL (2019)

Review Cardiac & Cardiovascular Systems

Treating oxidative stress in heart failure: past, present and future

Atze van der Pol et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

Article Respiratory System

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

Marc Humbert et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Biochemistry & Molecular Biology

MicroRNA-146a sponge therapy suppresses neointimal formation in rat vein grafts

Bo-Jun Cao et al.

IUBMB LIFE (2019)

Review Cell Biology

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

Kioomars Saliminejad et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Cardiac & Cardiovascular Systems

MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model

Hiroomi Nishio et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2019)

Review Pharmacology & Pharmacy

The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease

Francesca Vacante et al.

VASCULAR PHARMACOLOGY (2019)

Review Chemistry, Multidisciplinary

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Anna Sorushanova et al.

ADVANCED MATERIALS (2019)

Article Biochemistry & Molecular Biology

MiR-93 regulates vascular smooth muscle cell proliferation, and neointimal formation through targeting Mfn2

Shengdong Feng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Cardiac & Cardiovascular Systems

MicroRNA-132 targeting PTEN contributes to cilostazol-promoted vascular smooth muscle cell differentiation

Wei-Jan Chen et al.

ATHEROSCLEROSIS (2018)

Article Biochemistry & Molecular Biology

Regulatory crosstalk between KLF5, miR-29a and Fbw7/CDC4 cooperatively promotes atherosclerotic development

Bin Zheng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Medicine, Research & Experimental

MicroRNA-145 alleviates high glucose-induced proliferation and migration of vascular smooth muscle cells through targeting ROCK1

Mantian Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Medicine, Research & Experimental

MicroRNA-574-5p promotes cell growth of vascular smooth muscle cells in the progression of coronary artery disease

Zhongmeng Lai et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Cardiac & Cardiovascular Systems

Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms

John R. Petrie et al.

CANADIAN JOURNAL OF CARDIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

From genetics to response to injury: vascular smooth muscle cells in aneurysms and dissections of the ascending aorta

Jean-Baptiste Michel et al.

CARDIOVASCULAR RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis

Mandy O. J. Grootaert et al.

CARDIOVASCULAR RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Role of smooth muscle cells in coronary artery bypass grafting failure

Kerry Wadey et al.

CARDIOVASCULAR RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

Andrew L. Durham et al.

CARDIOVASCULAR RESEARCH (2018)

Article Cardiac & Cardiovascular Systems

MiR-135a Promotes Inflammatory Responses of Vascular Smooth Muscle Cells From db/db Mice via Downregulation of FOXO1

Xiaochun Lu et al.

INTERNATIONAL HEART JOURNAL (2018)

Article Biochemistry & Molecular Biology

MicroRNA-21 drives the switch to a synthetic phenotype in human saphenous vein smooth muscle cells

Aliah R. Alshanwani et al.

IUBMB LIFE (2018)

Article Medicine, Research & Experimental

UHRF1 epigenetically orchestrates smooth muscle cell plasticity in arterial disease

Leonardo Elia et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Medicine, Research & Experimental

Akt modulation by miR-145 during exercise-induced VSMC phenotypic switching in hypertension

Jingwen Liao et al.

LIFE SCIENCES (2018)

Article Biotechnology & Applied Microbiology

Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions

Hong Jin et al.

MOLECULAR THERAPY (2018)

Article Multidisciplinary Sciences

Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

Rafael Radi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Endocrinology & Metabolism

A Novel Regulator of Type II Diabetes: MicroRNA-143

Biao Li et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

Article Hematology

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

Isola A. M. Brown et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Circ-SATB2 upregulates STIM1 expression and regulates vascular smooth muscle cell proliferation and differentiation through miR-939

Yan-yang Mao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Cardiac & Cardiovascular Systems

Cbx3 inhibits vascular smooth muscle cell proliferation, migration, and neointima formation

Cheng Zhang et al.

CARDIOVASCULAR RESEARCH (2018)

Review Genetics & Heredity

Kruppel-like factor 4 (KLF4): What we currently know

Amr M. Ghaleb et al.

Article Medicine, Research & Experimental

MicroRNA-182 prevents vascular smooth muscle cell dedifferentiation via FGF9/PDGFR signaling

Nana Dong et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

Induction of MiR133a expression by IL-19 targets LDLRAPI. and reduces oxLDL uptake in VSMC

Khatuna Gabunia et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

MicroRNA-124 controls human vascular smooth muscle cell phenotypic switch via Sp1

Yangfeng Tang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

Article Hematology

Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504

Marpadga A. Reddy et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

Article Hematology

Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients

Lan Sun et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

Article Clinical Neurology

MicroRNA and gene expression changes in unruptured human cerebral aneurysms

Kimon Bekelis et al.

JOURNAL OF NEUROSURGERY (2016)

Review Neurosciences

Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation

A. N. Kapustin et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Article Cardiac & Cardiovascular Systems

NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia

Tayyab Adeel Afzal et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

Article Cardiac & Cardiovascular Systems

Novel Fabrication of MicroRNA Nanoparticle-Coated Coronary Stent for Prevention of Post-Angioplasty Restenosis

Hui-Lian Che et al.

KOREAN CIRCULATION JOURNAL (2016)

Article Hematology

Local MicroRNA Modulation Using a Novel Anti-miR21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis

Dong Wang et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1

Juan Xu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Cardiac & Cardiovascular Systems

Down-regulation of miR-23b induces phenotypic switching of vascular smoothmuscle cells in vitro and in vivo

Claudio Iaconetti et al.

CARDIOVASCULAR RESEARCH (2015)

Letter Cardiac & Cardiovascular Systems

miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation

Bin Zheng et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migration

Qishan Chen et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Article Cell Biology

Kaempferol inhibits vascular smooth muscle cell migration by modulating BMP-mediated miR-21 expression

Kwangho Kim et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2015)

Review Biotechnology & Applied Microbiology

Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling

Dmitry A. Chistiakov et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Biochemistry & Molecular Biology

miRNA-221 and miRNA-222 synergistically function to promote vascular calcification

N. C. W. Mackenzie et al.

CELL BIOCHEMISTRY AND FUNCTION (2014)

Article Biochemistry & Molecular Biology

Down-Regulation of miR-96 by Bone Morphogenetic Protein Signaling is Critical for Vascular Smooth Muscle Cell Phenotype Modulation

Sunghwan Kim et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2014)

Article Cardiac & Cardiovascular Systems

Effect of microRNA-145 to prevent vein graft disease in rabbits by regulation of smooth muscle cell phenotype

Motoaki Ohnaka et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2014)

Article Cardiac & Cardiovascular Systems

miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat

Elise Merlet et al.

CARDIOVASCULAR RESEARCH (2013)

Review Biochemical Research Methods

Extracellular matrix signaling in morphogenesis and repair

Kelly C. Clause et al.

CURRENT OPINION IN BIOTECHNOLOGY (2013)

Article Endocrinology & Metabolism

MiR-133a Modulates Osteogenic Differentiation of Vascular Smooth Muscle Cells

Xiao-Bo Liao et al.

ENDOCRINOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction

Fabiola Olivieri et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

Article Cell Biology

Elevation of miR-221 and-222 in the internal mammary arteries of diabetic subjects and normalization with metformin

Chasity B. Coleman et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2013)

Article Cardiac & Cardiovascular Systems

MicroRNA-204 regulates vascular smooth muscle cell calcification in vitro and in vivo

Rong-Rong Cui et al.

CARDIOVASCULAR RESEARCH (2012)

Article Cardiac & Cardiovascular Systems

MicroRNA-145 Targeted Therapy Reduces Atherosclerosis

Fina Lovren et al.

CIRCULATION (2012)

Article Cardiac & Cardiovascular Systems

miR-29b Participates in Early Aneurysm Development in Marfan Syndrome

Denis R. Merk et al.

CIRCULATION RESEARCH (2012)

Article Cardiac & Cardiovascular Systems

Serum levels of microRNAs in patients with heart failure

Yaron Goren et al.

EUROPEAN JOURNAL OF HEART FAILURE (2012)

Article Medicine, Research & Experimental

MicroRNAs that target Ca2+ transporters are involved in vascular smooth muscle cell calcification

Ting Gui et al.

LABORATORY INVESTIGATION (2012)

Article Cell Biology

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

Eduard Hergenreider et al.

NATURE CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

Mir-206 Regulates Pulmonary Artery Smooth Muscle Cell Proliferation and Differentiation

Samuel Jalali et al.

PLOS ONE (2012)

Article Cell Biology

MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion

Lars Maegdefessel et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Article Hematology

Induction of MicroRNA-1 by Myocardin in Smooth Muscle Cells Inhibits Cell Proliferation

Jie Chen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

New Horizons in Cardioprotection Recommendations From the 2010 National Heart, Lung, and Blood Institute Workshop

Lisa Schwartz Longacre et al.

CIRCULATION (2011)

Article Cardiac & Cardiovascular Systems

MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo

Daniele Torella et al.

CIRCULATION RESEARCH (2011)

Article Cardiac & Cardiovascular Systems

MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation

Reinier A. Boon et al.

CIRCULATION RESEARCH (2011)

Article Biochemistry & Molecular Biology

The miR-143/145 Cluster Is a Novel Transcriptional Target of Jagged-1/Notch Signaling in Vascular Smooth Muscle Cells

Joshua M. Boucher et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Cardiac & Cardiovascular Systems

Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome

Christian Widera et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)

Review Immunology

Type 2 diabetes as an inflammatory disease

Marc Y. Donath et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Article Hematology

MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function

Sebastian Albinsson et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

Article Medicine, Research & Experimental

A translational study of circulating cell-free microRNA-1 in acute myocardial infarction

Yunhui Cheng et al.

CLINICAL SCIENCE (2010)

Article Biochemistry & Molecular Biology

Repression of Versican Expression by MicroRNA-143

Xiaobo Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

The extracellular matrix at a glance

Christian Frantz et al.

JOURNAL OF CELL SCIENCE (2010)

Article Urology & Nephrology

The MicroRNA-Processing Enzyme Dicer Maintains Juxtaglomerular Cells

Maria Luisa S. Sequeira-Lopez et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Article Cardiac & Cardiovascular Systems

A Necessary Role of miR-221 and miR-222 in Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia

Xiaojun Liu et al.

CIRCULATION RESEARCH (2009)

Article Medical Laboratory Technology

Plasma miR-208 as a Biomarker of Myocardial Injury

Xu Ji et al.

CLINICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Induction of MicroRNA-221 by Platelet-derived Growth Factor Signaling Is Critical for Modulation of Vascular Smooth Muscle Phenotype

Brandi N. Davis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

Kimberly R. Cordes et al.

NATURE (2009)

Article Multidisciplinary Sciences

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

Tamia A. Harris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

MicroRNAs and other tiny endogenous RNAs in C-elegans

V Ambros et al.

CURRENT BIOLOGY (2003)

Article Medicine, General & Internal

Toll-like receptor 4 polymorphisms and atherogenesis

S Kiechl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)