Related references
Note: Only part of the references are listed.Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly
Hongjie Li et al.
SCIENCE (2022)
An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination
Oguz Kanca et al.
ELIFE (2022)
Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia
Liping Wang et al.
SCIENCE ADVANCES (2022)
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease
Priyanka Baloni et al.
COMMUNICATIONS BIOLOGY (2022)
Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function
Juyeon Jo et al.
EMBO REPORTS (2021)
ABCD1 and X-linked adrenoleukodystrophy: A disease with a markedly variable phenotype showing conserved neurobiology in animal models
Joshua Manor et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2021)
Neurotoxic reactive astrocytes induce cell death via saturated lipids
Kevin A. Guttenplan et al.
NATURE (2021)
Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes
Matthew J. Moulton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Brain inflammation triggers macrophage invasion across the blood-brain barrier in Drosophila during pupal stages
Bente Winkler et al.
SCIENCE ADVANCES (2021)
CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE
Huan Wang et al.
JCI INSIGHT (2021)
Characterization of the Drosophila Adult Hematopoietic System Reveals a Rare Cell Population With Differentiation and Proliferation Potential
Manon Boulet et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function
Ye-Jin Park et al.
ISCIENCE (2021)
Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases
Hirotaka Goto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
Myelin-specific CD8(+) T cells exacerbate brain inflammation in CNS autoimmunity
Catriona A. Wagner et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction
Nadav I. Weinstock et al.
NEURON (2020)
Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms
Hyung-lok Chung et al.
NEURON (2020)
The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation
Xiaoyun Ding et al.
GENES & DEVELOPMENT (2020)
White matter and neurological disorders
Han-Gyu Bae et al.
ARCHIVES OF PHARMACAL RESEARCH (2020)
Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation
Alessandra Roggeri et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Brainstem development requires galactosylceramidase and is critical for pathogenesis in a model of Krabbe disease
Nadav Weinstock et al.
NATURE COMMUNICATIONS (2020)
The role of glial-neuronal metabolic cooperation in modulating progression of multiple sclerosis and neuropathic pain
Rachel R. Robinson et al.
IMMUNOTHERAPY (2019)
The ORMDL/Orm-serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes
Deanna L. Davis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington's Disease Pre-clinical Model
Alba Di Pardo et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)
Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases
Sara Grassi et al.
FRONTIERS IN PHARMACOLOGY (2019)
Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis
Claudia Volpi et al.
EXPERT OPINION ON DRUG DISCOVERY (2019)
Glial Phagocytic Receptors Promote Neuronal Loss in Adult Drosophila Brain
Ketty Hakim-Mishnaevski et al.
CELL REPORTS (2019)
An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms
Oguz Kanca et al.
eLife (2019)
Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing
Qingyun Li et al.
NEURON (2019)
A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain
Kristofer Davie et al.
CELL (2018)
Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain
Guang Lin et al.
CELL METABOLISM (2018)
Multiple Sclerosis: Mechanisms and Immunotherapy
Clare Baecher-Allan et al.
NEURON (2018)
Normal aging induces A1-like astrocyte reactivity
Laura E. Clarke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation
Christina F. Vogelaar et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Tools Allowing Independent Visualization and Genetic Manipulation of Drosophila melanogaster Macrophages and Surrounding Tissues
Attila Gyoergy et al.
G3-GENES GENOMES GENETICS (2018)
Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders
Alba Di Pardo et al.
FRONTIERS IN NEUROSCIENCE (2018)
White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes
Sara E. Nasrabady et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)
Screening and Analysis of Janelia FlyLight Project Enhancer-Gal4 Strains Identifies Multiple Gene Enhancers Active During Hematopoiesis in Normal and Wasp-Challenged Drosophila Larvae
Tsuyoshi Tokusumi et al.
G3-GENES GENOMES GENETICS (2017)
The Glia of the Adult Drosophila Nervous System
Malte C. Kremer et al.
GLIA (2017)
A zebrafish model of X-linked adrenoleukodystrophy recapitulates key disease features and demonstrates a developmental requirement for abcd1 in oligodendrocyte patterning and myelination
Lauren R. Strachan et al.
HUMAN MOLECULAR GENETICS (2017)
Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications
Andreas R. Janecke et al.
HUMAN MUTATION (2017)
CNS inflammation and neurodegeneration
Tanuja Chitnis et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome
Rathi Prasad et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency
Svjetlana Lovric et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Effect of Fingolimod on Neural Stem Cells: A Novel Mechanism and Broadened Application for Neural Repair
Yuan Zhang et al.
MOLECULAR THERAPY (2017)
The role of peripheral immune cells in the CNS in steady state and disease
Marco Prinz et al.
NATURE NEUROSCIENCE (2017)
The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D
Lucy Liu et al.
CELL METABOLISM (2017)
MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome
Julia Wang et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2017)
S1P1 Deletion in Oligodendroglial Lineage Cells: Effect on Differentiation and Myelination
Danuta E. Dukala et al.
GLIA (2016)
Axon ensheathment and metabolic supply by glial cells in Drosophila
Stefanie Schirmeier et al.
BRAIN RESEARCH (2016)
Drosophila Schipl Links Expanded and Tao-1 to Regulate Hippo Signaling
Hyung-Lok Chung et al.
DEVELOPMENTAL CELL (2016)
New tools for studying microglia in the mouse and human CNS
Mariko L. Bennett et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Sphingosine 1-Phosphate Receptor Modulators in Multiple Sclerosis
Adnan M. Subei et al.
CNS DRUGS (2015)
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
Richard L. Proia et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster
Claude Wicker-Thomas et al.
JOURNAL OF LIPID RESEARCH (2015)
Sterile Inflammation in Drosophila
Zeeshan Shaukat et al.
MEDIATORS OF INFLAMMATION (2015)
Drosophila Central Nervous System Glia
Marc R. Freeman
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
Plug-and-Play Genetic Access to Drosophila Cell Types using Exchangeable Exon Cassettes
Fengqiu Diao et al.
CELL REPORTS (2015)
Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology
Takayuki Sassa et al.
BIOMOLECULES & THERAPEUTICS (2014)
A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases
Shinya Yamamoto et al.
CELL (2014)
Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein
Ilker Karaca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
An update on the biology of sphingosine 1-phosphate receptors
Victoria A. Blaho et al.
JOURNAL OF LIPID RESEARCH (2014)
Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila
Fillip Port et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Genetic elevation of Sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila
Mario Pantoja et al.
DEVELOPMENT (2013)
Highly Improved Gene Targeting by Germline-Specific Cas9 Expression in Drosophila
Shu Kondo et al.
GENETICS (2013)
Ceramide Phosphoethanolamine Biosynthesis in Drosophila Is Mediated by a Unique Ethanolamine Phosphotransferase in the Golgi Lumen
Ana M. Vacaru et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
A new metabolomic workflow for early detection of Alzheimer's disease
Clara Ibanez et al.
JOURNAL OF CHROMATOGRAPHY A (2013)
Biological functions of sphingomyelins
J. Peter Slotte
PROGRESS IN LIPID RESEARCH (2013)
FlyPrimerBank: An Online Database for Drosophila melanogaster Gene Expression Analysis and Knockdown Evaluation of RNAi Reagents
Yanhui Hu et al.
G3-GENES GENOMES GENETICS (2013)
A Global In Vivo Drosophila RNAi Screen Identifies a Key Role of Ceramide Phosphoethanolamine for Glial Ensheathment of Axons
Aniket Ghosh et al.
PLOS GENETICS (2013)
A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells
Takayuki Sassa et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)
Mammalian ORMDL Proteins Mediate the Feedback Response in Ceramide Biosynthesis
Deanna L. Siow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice
Shigetomo Fukuhara et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation
Marc Engelen et al.
JOURNAL OF INHERITED METABOLIC DISEASE (2012)
Fiji: an open-source platform for biological-image analysis
Johannes Schindelin et al.
NATURE METHODS (2012)
Bezafibrate for X-Linked Adrenoleukodystrophy
Marc Engelen et al.
PLOS ONE (2012)
Sphingosine-1-phosphate signaling and its role in disease
Michael Maceyka et al.
TRENDS IN CELL BIOLOGY (2012)
An integrative approach to ortholog prediction for disease-focused and other functional studies
Yanhui Hu et al.
BMC BIOINFORMATICS (2011)
Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
Cris S. Constantinescu et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors
Ikuko Yonamine et al.
JOURNAL OF CELL BIOLOGY (2011)
Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models
Roman Chrast et al.
JOURNAL OF LIPID RESEARCH (2011)
Spinster Controls Dpp Signaling during Glial Migration in the Drosophila Eye
Yeliz Yuva-Aydemir et al.
JOURNAL OF NEUROSCIENCE (2011)
FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
Ji Woong Choi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Central nervous system myelin: structure, synthesis and assembly
Shweta Aggarwal et al.
TRENDS IN CELL BIOLOGY (2011)
Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids
Delphine Milhas et al.
FEBS LETTERS (2010)
Myelination and support of axonal integrity by glia
Klaus-Armin Nave
NATURE (2010)
Systematic genetic analysis of muscle morphogenesis and function in Drosophila
Frank Schnorrer et al.
NATURE (2010)
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
Volker Brinkmann et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis
Alina Kulakowska et al.
NEUROSCIENCE LETTERS (2010)
Lineage Tracing of Lamellocytes Demonstrates Drosophila Macrophage Plasticity
Martin Stofanko et al.
PLOS ONE (2010)
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis
Yusuke Ohno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila
Reinhard Bauer et al.
EMBO JOURNAL (2009)
Regulation and function of the melanization reaction in Drosophila
Huaping Tang
FLY (2009)
Adult Ceramide Synthase 2 (CERS2)-deficient Mice Exhibit Myelin Sheath Defects, Cerebellar Degeneration, and Hepatocarcinomas
Silke Imgrund et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Ensheathing Glia Function as Phagocytes in the Adult Drosophila Brain
Johnna Doherty et al.
JOURNAL OF NEUROSCIENCE (2009)
Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology
Tao Liu et al.
GENOME BIOLOGY (2009)
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
Cungui Mao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2008)
Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
Jennifer S. Ziegenfuss et al.
NATURE (2008)
Cell-nonautonomous function of ceramidase in photoreceptor homeostasis
Jairaj K. Acharya et al.
NEURON (2008)
Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: Consequences for mode of action in multiple sclerosis
Carolyn A. Foster et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
A κB sequence code for pathway-specific innate immune responses
Matthew S. Busse et al.
EMBO JOURNAL (2007)
Definition of Drosophila hemocyte subsets by cell-type specific antigens
Eva Kurucz et al.
ACTA BIOLOGICA HUNGARICA (2007)
PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan
Takashi Kaneko et al.
NATURE IMMUNOLOGY (2006)
The Drosophila cell corpse engulfment receptor draper mediates glial clearance of severed axons
Jennifer M. MacDonald et al.
NEURON (2006)
Genetic mosaic with dual binary transcriptional systems in Drosophila
SL Lai et al.
NATURE NEUROSCIENCE (2006)
Ageing and the brain
R Peters
POSTGRADUATE MEDICAL JOURNAL (2006)
Active induction of experimental allergic encephalomyelitis
Ingunn M. Stromnes et al.
NATURE PROTOCOLS (2006)
Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer
B Dermaut et al.
JOURNAL OF CELL BIOLOGY (2005)
Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network
H Rosen et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Enzymes of sphingolipid metabolism in Drosophila melanogaster
U Acharya et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
Cellular and genetic analysis of wound healing in Drosophila larvae
MJ Galko et al.
PLOS BIOLOGY (2004)
Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes
SA Sinenko et al.
ONCOGENE (2004)
Sphingosine-1-phosphate: An enigmatic signalling lipid
S Spiegel et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Unrestricted synaptic growth in spinster -: A late endosomal protein implicated in TGF-β-mediated synaptic growth regulation
ST Sweeney et al.
NEURON (2002)
An immune-responsive serpin regulates the melanization cascade in Drosophila
E De Gregorio et al.
DEVELOPMENTAL CELL (2002)
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
M Gottar et al.
NATURE (2002)
Oligoclonal expansion of memory CD8(+) T cells in cerebrospinal fluid from multiple sclerosis patients
M Jacobsen et al.
BRAIN (2002)
Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster
Y Nakano et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Clonal expansions of CD8+ T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
H Babbe et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
Myelin synthesis in the peripheral nervous system
B Garbay et al.
PROGRESS IN NEUROBIOLOGY (2000)