4.7 Article

The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection

Related references

Note: Only part of the references are listed.
Review Microbiology

Clostridioides difficile spore germination: initiation to DPA release

Marko Baloh et al.

Summary: This review provides an overview of the understanding of C. difficile spore germination, including the factors involved in germinant recognition, cortex degradation and DPA release.

CURRENT OPINION IN MICROBIOLOGY (2022)

Article Chemistry, Multidisciplinary

Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives

Walter Hofer et al.

Summary: The rise of antimicrobial resistance poses a severe threat to public health. Chlorotonil, a new antibiotic targeting multidrug resistant pathogens, was found to have promising activities. However, its pharmaceutical properties needed improvement. By semisynthesis, derivatives with enhanced solubility were obtained, and their stability and activity were verified in vivo.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Microbiology

The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia

A. D. Reed et al.

Summary: Proline is an essential amino acid used by C. difficile for growth and disease. Its modified form, hydroxyproline, is abundant in collagen and can be degraded by host proteases. The ability to dehydrate hydroxyproline is widespread among gut microbiota, including C. difficile and commensal Clostridia. In vitro experiments showed that C. difficile and other Clostridia strains had different alterations in gene expression in the presence of hydroxyproline, suggesting that its metabolism could affect nutrient competition. Further understanding of these differences will be important in determining their role.

MSPHERE (2022)

Article Microbiology

A Vancomycin HPLC Assay for Use in Gut Microbiome Research

Chenlin Hu et al.

Summary: The human microbiome project has revolutionized our understanding of the interaction between commensal microbes and human health. In this study, a simple and fast HPLC method was validated for quantitative fecal vancomycin analysis and the reproducibility of results were tested, establishing sample condition standards for quantitative HPLC studies on vancomycin pharmacokinetics with the human microbiome.

MICROBIOLOGY SPECTRUM (2022)

Article Microbiology

In vivo commensal control of Clostridioides difficile virulence

Brintha P. Girinathan et al.

Summary: Different species of Clostridia can protect against or worsen Clostridioides difficile infection in mice by modulating the pathogen's colonization, growth, and virulence through altering the gut-nutrient environment. This research lays the groundwork for mechanistically informed therapies to counter C. difficile disease using systems biology approaches to define host-commensal-pathogen interactions in vivo.

CELL HOST & MICROBE (2021)

Article Multidisciplinary Sciences

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

Joshua R. Fletcher et al.

Summary: Through the analysis of tcdR mutants in two strains of Clostridioides difficile and omics, this study found that toxin-induced inflammation significantly alters the metabolism pathways of C. difficile and the gut microbiota. The host cell gene expression characteristics promote the in vivo growth of C. difficile. Furthermore, inflammation induced by C. difficile toxin activity excludes Bacteroides genus members that can utilize essential nutrients released from collagen degradation.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Unravelling the collateral damage of antibiotics on gut bacteria

Lisa Maier et al.

Summary: The study categorized the activity spectra of antibiotics in gut bacteria, revealing distinct inhibition patterns of different antibiotic classes. The findings suggest potential strategies to protect beneficial bacteria by screening for drugs that counteract antibiotic activity.

NATURE (2021)

Review Microbiology

Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium

Amber D. Reed et al.

Summary: Commensal Clostridium in the gut play a crucial role in resisting colonization by Clostridioides difficile by altering bile acids, producing inhibitory metabolites, and competing for essential nutrients. Understanding the mechanisms of action of these metabolites on C. difficile and other gut pathogens is essential for developing urgently needed new therapeutics for C. difficile infection.

MICROORGANISMS (2021)

Review Microbiology

A short chain fatty acid-centric view of Clostridioides difficile pathogenesis

Anna L. Gregory et al.

Summary: Clostridioides difficile is an opportunistic diarrheal pathogen with significant global morbidity and mortality. Disrupted gut microbiome, often caused by antibiotic treatment, is the primary risk factor for C. difficile infection, emphasizing the critical role of C. difficile-microbiome interactions. Short chain fatty acids (SCFAs) in the gut, produced by the gut microbiome, have impacts on the host and C. difficile biology. Understanding the relationship between C. difficile and SCFAs may lead to new approaches for managing C. difficile infection and other gastrointestinal pathogens.

PLOS PATHOGENS (2021)

Article Microbiology

Bile acid-independent protection against Clostridioides difficile infection

Andrea Martinez Aguirre et al.

Summary: Infections of Clostridioides difficile result from disruptions to the normal colonic microbiota, often caused by broad-spectrum antibiotics. While secondary bile acids are toxic to C. difficile, their generation through 7 alpha-dehydroxylation is not necessary for protection against C. difficile infection. Instead, bacteria that 7 alpha-dehydroxylate primary bile acids protect against C. difficile through bile acid-independent mechanisms, suggesting that Stickland metabolism plays a key role in consuming essential nutrients for C. difficile growth.

PLOS PATHOGENS (2021)

Article Multidisciplinary Sciences

Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics

Cornelis H. van Werkhoven et al.

Summary: This study reports the incidence of Clostridioides difficile infection (CDI) and assesses potential clinical characteristics and biomarkers to predict CDI in 1,007 patients aged 50 and above receiving newly initiated antibiotic treatment.

NATURE COMMUNICATIONS (2021)

Article Microbiology

Clearance of Clostridioides difficile Colonization Is Associated with Antibiotic-Specific Bacterial Changes

Nicholas A. Lesniak et al.

Summary: The gut bacterial community plays a crucial role in preventing pathogens like C. difficile from colonizing and causing infection. Different antibiotic treatments result in varying changes in the bacterial community, affecting the ability to clear C. difficile colonization. Understanding how different gut bacterial communities eliminate C. difficile colonization will help improve C. difficile infection treatments in the future.

MSPHERE (2021)

Review Infectious Diseases

Burden of Clostridioides difficile infection (CDI)-a systematic review of the epidemiology of primary and recurrent CDI

Elaine Finn et al.

Summary: This study summarized the evidence on the epidemiology and clinical burden of Clostridioides difficile infection, finding variations in incidence rates and risk factors across different countries.

BMC INFECTIOUS DISEASES (2021)

Review Chemistry, Multidisciplinary

Towards the sustainable discovery and development of new antibiotics

Marcus Miethke et al.

Summary: There is a growing demand for novel antimicrobials to treat infections caused by multidrug-resistant bacterial pathogens, but there is currently a lack of investment in this field. New agents with innovative chemistry and modes of action are urgently needed to combat the public health threat posed by antimicrobial resistance. The consortium proposes short-term and long-term solutions to overcome urgent limitations in research and funding, aiming to bridge the gap between academic, industrial, and political stakeholders to improve the ability to discover and develop new antibiotics.

NATURE REVIEWS CHEMISTRY (2021)

Review Gastroenterology & Hepatology

Evolution of clinical guidelines for antimicrobial management of Clostridioides difficile infection

Abdelkader Chaar et al.

Summary: Clostridioides difficile infection (CDI) has been an epidemic for many years, with the biggest challenge being preventing recurrence. Clinical treatment guidelines have evolved over time, moving from earlier recommendations of drug treatments to modern recommendations with multiple options and immune-boosting therapies.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2021)

Article Biochemical Research Methods

DEqMS: A Method for Accurate Variance Estimation in Differential Protein Expression Analysis

Yafeng Zhu et al.

MOLECULAR & CELLULAR PROTEOMICS (2020)

Review Public, Environmental & Occupational Health

Antimicrobial resistance inClostridioides(Clostridium)difficilederived from humans: a systematic review and meta-analysis

Mohammad Sholeh et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2020)

Article Biochemical Research Methods

Virulence Factors Produced by Staphylococcus aureus Biofilms Have a Moonlighting Function Contributing to Biofilm Integrity

Alexander C. Graf et al.

MOLECULAR & CELLULAR PROTEOMICS (2019)

Article Evolutionary Biology

Day and Night: Metabolic Profiles and Evolutionary Relationships of Six Axenic Non-Marine Cyanobacteria

Sabine Eva Will et al.

GENOME BIOLOGY AND EVOLUTION (2019)

Review Gastroenterology & Hepatology

Treatment of recurrent Clostridium difficile colitis: a narrative review

Roy J. Hopkins et al.

GASTROENTEROLOGY REPORT (2018)

Article Medicine, General & Internal

Clostridium difficile infection and antibiotic-associated diarrhoea

Benjamin H. Mullish et al.

CLINICAL MEDICINE (2018)

Article Infectious Diseases

Short- and long-term effects of oral vancomycin on the human intestinal microbiota

Sandrine Isaac et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2017)

Article Biochemical Research Methods

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

Stefka Tyanova et al.

NATURE PROTOCOLS (2016)

Article Microbiology

A reference gene catalogue of the pig gut microbiome

Liang Xiao et al.

NATURE MICROBIOLOGY (2016)

Article Multidisciplinary Sciences

IMNGS: A comprehensive open resource of processed 16S rRNA microbial profiles for ecology and diversity studies

Ilias Lagkouvardos et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Two of a Kind-The Biosynthetic Pathways of Chlorotonil and Anthracimycin

Katrin Jungmann et al.

ACS CHEMICAL BIOLOGY (2015)

Article Food Science & Technology

Gut metabolites and bacterial community networks during a pilot intervention study with flaxseeds in healthy adult men

Ilias Lagkouvardos et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2015)

Article Microbiology

Antimalarial Activity of the Myxobacterial Macrolide Chlorotonil A

Jana Held et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

Article Gastroenterology & Hepatology

Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile

Robert A. Britton et al.

GASTROENTEROLOGY (2014)

Review Biochemistry & Molecular Biology

Clostridium difficile spore biology: sporulation, germination, and spore structural proteins

Daniel Paredes-Sabja et al.

TRENDS IN MICROBIOLOGY (2014)

Article Microbiology

Proline-Dependent Regulation of Clostridium difficile Stickland Metabolism

Laurent Bouillaut et al.

JOURNAL OF BACTERIOLOGY (2013)

Article Biochemical Research Methods

SINA: Accurate high-throughput multiple sequence alignment of ribosomal RNA genes

Elmar Pruesse et al.

BIOINFORMATICS (2012)

Article Immunology

Treatment of First Recurrence of Clostridium difficile Infection: Fidaxomicin Versus Vancomycin

Oliver A. Comely et al.

CLINICAL INFECTIOUS DISEASES (2012)

Article Biochemical Research Methods

UCHIME improves sensitivity and speed of chimera detection

Robert C. Edgar et al.

BIOINFORMATICS (2011)

Article Medicine, General & Internal

Fidaxomicin versus Vancomycin for Clostridium difficile Infection

Thomas J. Louie et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Multidisciplinary Sciences

Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample

J. Gregory Caporaso et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemical Research Methods

Search and clustering orders of magnitude faster than BLAST

Robert C. Edgar

BIOINFORMATICS (2010)

Software Review Chemistry, Multidisciplinary

Fityk: a general-purpose peak fitting program

Marcin Wojdyr

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2010)

Article Multidisciplinary Sciences

FastTree 2-Approximately Maximum-Likelihood Trees for Large Alignments

Morgan N. Price et al.

PLOS ONE (2010)

Article Chemistry, Multidisciplinary

Chlorotonil A, a macrolide with a unique gem-dichloro-1,3-dione functionality from Sorangium cellulosum, So ce1525

Klaus Gerth et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

Article Biotechnology & Applied Microbiology

Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy

Qiong Wang et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)

Article Biotechnology & Applied Microbiology

UniFrac: a new phylogenetic method for comparing microbial communities

C Lozupone et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2005)