Cellular crosstalk in atherosclerotic plaque microenvironment

Atherosclerosis is an underlying pathology of many vascular diseases as a result of cellular, structural and molecular dysfunctions within the sub-endothelial space. This review deals with the events involved in the formation, growth and remodeling of plaque, including the cell recruitment, cell polarization, and cell fat droplets. It also describes cross talking between endothelial cells, macrophages, and vascular smooth muscle cells, as well as the cellular pathways involved in plaque development in the plaque microenvironment. Finally, it describes the plaque structural components and the role of factors involved in the rupture and erosion of plaques in the vessel.

Automated summary

This review summarizes the cellular, structural, and molecular dysfunctions involved in the formation, growth, and remodeling of atherosclerotic plaques. It discusses the recruitment, polarization, and accumulation of cells, as well as the communication between endothelial cells, macrophages, and vascular smooth muscle cells in the plaque microenvironment. Additionally, it elaborates on the structural components of plaques and the factors contributing to their rupture and erosion in the vessel.