Related references
Note: Only part of the references are listed.
Article
Oncology
Nicholas R. Anderson et al.
Summary: Using a mouse model of FLT3-ITD AML, researchers found that FLT3-ITD AML LSC were enriched within the ST-HSC population and had increased expression of CXCR4. Deletion of CXCL12 from the microenvironment enhanced targeting of AML cells by Flt3-TKI plus chemotherapy treatment, including enhanced LSC targeting. Inhibition of p38 signaling reduced the maintenance of Flt3-ITD AML LSC and enhanced their sensitivity to treatment.
Article
Endocrinology & Metabolism
Yunyi Xu et al.
Summary: This study reveals a novel regulatory mechanism involving SOX9, HMGB3, and NANOG in prostate cancer progression. SOX9 activates the transcription of NANOG by binding to a specific cis-regulatory element in its promoter, and HMGB3 acts as a partner of SOX9 to enhance this transactivation. Overexpression of SOX9 and HMGB3 is associated with increased cell survival, cell migration, and poor prognosis in prostate cancer.
Review
Oncology
Maria Ovejero-Sanchez et al.
Summary: This article reviews the alterations in DNA damage response (DDR) pathways in ovarian cancer (OC), and the therapeutic potential of targeting the DDR for the treatment of OC. Failures in DDR have been associated with the development, progression, and chemoresistance of OC. Defects in DNA repair pathways, such as DNA double-strand break repair by homologous recombination and ARID1A mutations, have been found in different OC subtypes. Preclinical and clinical studies have shown promise in targeting the DDR to fight OC.
Review
Oncology
Susana Banerjee et al.
Summary: This article discusses the research progress on NaPi2b as a novel biomarker for treatment and patient selection in ovarian cancer. NaPi2b is highly expressed in ovarian tumors and can be used for tumor mapping and therapeutic targeting. Clinical trial results have shown successful detection of NaPi2b in ovarian cancer patients, and it has the potential to elicit therapeutic responses.
CANCER TREATMENT REVIEWS
(2023)
Article
Oncology
Shuai Dong et al.
Summary: This study found that the expressions of SYT7 and HMGB3 were significantly upregulated in thyroid cancer tissues and cells. SYT7 could regulate the ubiquitination of HMGB3 through its interaction with BRCA1, thereby affecting the progression of thyroid cancer.
ENDOCRINE-RELATED CANCER
(2022)
Article
Medicine, General & Internal
Changfa Xia et al.
Summary: The study compared the latest cancer profiles, trends, and determinants between China and the USA in 2022. China has a higher incidence of lung cancer, while the USA has more cases of breast cancer. Recent years have seen a significant decrease in lung and colorectal cancer rates in the USA, while liver cancer rates have slightly increased. In China, rates for stomach, liver, and esophageal cancer have decreased gradually, but colorectal cancer rates have increased for the whole population.
CHINESE MEDICAL JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Sriya Kudaravalli et al.
Summary: Therapeutic resistance and metastatic progression are the main causes of cancer deaths, with cancer stem cells (CSCs) playing a crucial role in these processes. p38 MAPK is important for CSC development and maintenance, and its targeting can enhance chemotherapy sensitivity and prevent metastatic progression.
Article
Cell Biology
Hanlin Ma et al.
Summary: This study found that the overexpression of HMGB3 is associated with shorter overall survival and drug resistance in high-grade serous ovarian carcinoma. HMGB3 interacts with PARP1 to promote PARPi resistance, and targeted inhibition of HMGB3 may overcome PARPi resistance in ovarian cancer therapy.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Ashok Iyaswamy et al.
Summary: The accumulation of phosphorylated Tau aggregates and A beta oligomers are crucial factors in the development of Alzheimer's disease. A study found that the fluorescent probe F-SLOH effectively inhibited A beta aggregation and reduced various neuropathological changes in AD mouse models by promoting autophagy lysosomal degradation pathway.
Article
Cell Biology
Wenjing Gong et al.
Summary: This study found that HMGB3 is highly expressed in colorectal cancer and is associated with patients' survival rate and immune infiltration. Knockdown of HMGB3 can downregulate proteins associated with colorectal cancer, suggesting that HMGB3 may serve as an important target for future colorectal cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Dale W. Garsed et al.
Summary: This study analyzed the genomic, transcriptomic, and methylomic profiles of patients with advanced-stage HGSC who survived more than 10 years after diagnosis. Long-term survivors had more alterations in DNA repair genes and higher neoantigen load. Patients were clustered into survival groups based on genomic and immune cell signatures, including different subsets of patients with BRCA1 alterations. Specific combinations of genetic and immune factors contribute to long-term survival in HGSC.
Article
Oncology
Junfen Xu et al.
Summary: This study characterized the heterogeneity of HGSOC using single-cell RNA sequencing, revealing a gene model for predicting patient outcomes, major cell components in the tumor microenvironment, and potential immunotherapeutic value.
CLINICAL CANCER RESEARCH
(2022)
Review
Immunology
Taiqing Liu et al.
Summary: Ovarian cancer is a common gynecologic malignancy with poor prognosis and high mortality. The tumor microenvironment in ovarian cancer is regulated by interferons (IFNs), which have bidirectional effects on cancer cell growth and immune cell activation. IFNs can assist in various types of therapy for ovarian cancer, except for some pathways that may cause drug resistance. IFNs have the potential to modulate the tumor microenvironment and provide new combination strategies for ovarian cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
P. K. Harinee Throwba et al.
Summary: There is a potential correlation between ovarian cancer, endometriosis, and PCOS, which may trigger cancer progression and metastasis through genetic and epigenetic factors.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Priyanshu Sharma et al.
Summary: This study reveals, for the first time, the role of HMGB3 in the regulation of autophagy and apoptosis in breast cancer cells, and it has therapeutic implications.
Review
Biochemistry & Molecular Biology
Dibyashree Chhetri et al.
Summary: DCLK1, a tumor stem cell marker in various cancers, is closely associated with tumor cell proliferation and metastasis. Targeting the DCLK1 gene and regulating the pathways controlled by DCLK1 may provide potential strategies to inhibit tumor growth and metastasis in gastrointestinal cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Karthikeyan Selvarasu et al.
Summary: This study found that KIF5B is involved in tau homeostasis in AD cells and animal models. By decreasing KIF5B levels, abnormal tau behavior can be reduced, thereby preventing and slowing down AD and other tauopathies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, Research & Experimental
Yaqi Zhang et al.
Summary: This study identified FOXK2 as a highly expressed stemness-specific transcription factor in ovarian cancer, which regulates the expression of IRE1? and activates stemness pathways. The findings shed light on potentially targetable pathways in cancer stem cells (CSCs) and provide valuable insights for developing new treatments.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Bin Wen et al.
Summary: The HMGB protein family, including HMGB1, HMGB2, HMGB3, and HMGB4, regulates DNA replication, transcription, recombination, and repair, and functions as cytokines mediating responses to infection, injury, and inflammation. Among them, HMGB3 plays a crucial role in regulating normal hematopoietic stem cells and its expression levels are closely related to leukemia development.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Marco Giordano et al.
Summary: This study implicates L1CAM in the tumorigenic function of OCSC, showing that L1CAM promotes stemness-related properties in OC cells and tumor initiation. The L1CAM/FGFR1/SRC/STAT3 signaling pathway is identified as a novel driver of OC stemness, providing evidence for potential OC eradication through targeting this pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Musalula Sinkala et al.
Summary: The study revealed the correlation between mutations in MAPK pathway genes and patient prognosis, as well as the dose-responses of cancer cells to MAPK pathway inhibitors, providing new insights for guiding the development of innovative therapies. The vulnerabilities in specific pathway genes identified in this study have great potential for clinical applications in guiding the use of MAPK targeting drugs.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell Biology
Ping Liu et al.
Summary: High expression of lncRNA CTBP1-DT in high-grade serous ovarian cancer (HGSOC) is associated with poor prognosis and promotes malignant biological behaviour of cancer cells by competitively binding to miR-188-5p to protect MAP3K3 from degradation. These findings suggest that lncRNA CTBP1-DT may serve as a potential biomarker and therapeutic target for HGSOC progression.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Xiaodan Zhong et al.
Summary: By data mining and experimental research, it was found that HMGB3 plays an important role in neuroblastoma, promoting cell growth, proliferation, and invasion, and is associated with unfavorable clinical outcomes in patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Cheng-Xi Sun et al.
Summary: MiR-216a is hypermethylated in the promoter region in esophageal cancer, leading to downregulation, while its downstream protein HMGB3 is upregulated. MiR-216a can affect cell proliferation, migration, invasion, apoptosis, and the activity of the Wnt/beta-catenin pathway in esophageal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Linlin Yuan et al.
Summary: The identification of an RNA called LINC00319 that is associated with worse outcomes for LSCC patients could lead to new therapeutic approaches for this form of throat cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Kaiwen Zhang et al.
Summary: High expression of HMGB3 in nasopharyngeal carcinoma is associated with micronuclei formation and metastasis, while HMGB3-containing nEXOs from NPC cells can accelerate angiogenesis and correlate positively with tumor metastasis. This study suggests that nEXO HMGB3 could serve as a significant biomarker for NPC metastasis and provide a basis for anti-angiogenesis therapy in clinical metastasis.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Isha Gaurav et al.
Summary: Peptides, consisting of amino acid strings, have gained significant attention in cancer research for their advantages, such as better biosafety and targeting ability. Conjugating peptides with nano delivery systems provides targeted delivery benefits for cancer therapy, and has potential for diagnosing malignant cancer progression.
Article
Oncology
Zhiyuan Hu et al.
Review
Biochemistry & Molecular Biology
Shannon Lee et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Yunjing Li et al.
BIOLOGICAL CHEMISTRY
(2020)
Article
Oncology
Shichao Zhuang et al.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2020)
Article
Oncology
Anirban Mukherjee et al.
Review
Oncology
Cornelia Braicu et al.
Article
Multidisciplinary Sciences
Zheying Zhang et al.
Article
Multidisciplinary Sciences
Michael J. Nemeth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2006)
Article
Hematology
MJ Nemeth et al.