Journal
CELL
Volume 186, Issue 4, Pages 690-692Publisher
CELL PRESS
DOI: 10.1016/j.cell.2023.01.004
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A study in Science shows that reducing gut bacteria in mice with genetic risk for AD can reduce neuropathology, but this effect is sex-dependent. This effect can be reversed by administering short-chain fatty acids, suggesting that specific bacterial metabolites increase susceptibility to AD.
The gut microbiota is implicated in risk for Alzheimer's disease (AD). A study in Science reports that depleting gut bacteria in mice with genetic risk for AD reduces neuropathology in a sex-dependent manner. This is reversed by administering short-chain fatty acids, suggesting that specific bacterial metabolites increase susceptibility to AD.
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