The unknown functions of a known protein: the case of coagulation factor XI

Letter Cardiac & Cardiovascular Systems

Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure With Preserved Ejection Fraction

Yang Cao et al.

CIRCULATION (2022)

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Editorial Material Cardiac & Cardiovascular Systems

What to expect from drug targeting factor XI?

Magdolna Nagy et al.

CARDIOVASCULAR RESEARCH (2022)

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Article Multidisciplinary Sciences

Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure

Yang Cao et al.

Summary: Tissue-tissue communication through endocrine factors is crucial for physiological homeostasis. A study on mice showed that coagulation factor XI (FXI), a protein derived from the liver, protects against diastolic dysfunction, a key trait of heart failure with preserved ejection fraction. FXI was found to activate the BMP-SMAD1/5 pathway in the heart and inhibit genes associated with inflammation and fibrosis, by cleaving and activating extracellular matrix-associated BMP7. This study reveals a protective role of FXI in heart injury that is separate from its role in blood coagulation.

SCIENCE (2022)

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Review Medicine, General & Internal