Journal
CANCER SCIENCE
Volume 114, Issue 7, Pages 2787-2797Publisher
WILEY
DOI: 10.1111/cas.15814
Keywords
antitumor immunity; CD8(+) T cell; Cxcr3; Utx
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CD8(+) T cells are important for antitumor immune responses and Utx plays a role in regulating their effector function. In this study, it was found that Utx promotes CD8(+) T-cell-dependent antitumor immune responses through epigenetic regulation.
CD8(+) T cells play a central role in antitumor immune responses. Epigenetic gene regulation is essential to acquire the effector function of CD8(+) T cells. However, the role of Utx, a demethylase of histone H3K27, in antitumor immunity remains unclear. In this study, we examined the roles of Utx in effector CD8(+) T-cell differentiation and the antitumor immune response. In a murine tumor-bearing model, an increased tumor size and decreased survival rate were observed in T-cell-specific Utx KO (Utx KO) mice compared with wild-type (WT) mice. The number of CD8(+) T cells in tumor-infiltrating lymphocytes (TILs) was significantly decreased in Utx KO mice. We found that the acquisition of effector function was delayed and attenuated in Utx KO CD8(+) T cells. RNA sequencing revealed that the expression of effector signature genes was decreased in Utx KO effector CD8(+) T cells, while the expression of naive or memory signature genes was increased. Furthermore, the expression of Cxcr3, which is required for the migration of effector CD8(+) T cells to tumor sites, was substantially decreased in Utx KO CD8(+) T cells. These findings suggest that Utx promotes CD8(+) T-cell-dependent antitumor immune responses partially through epigenetic regulation of the effector function.
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