Journal
CANCER SCIENCE
Volume 114, Issue 7, Pages 2931-2938Publisher
WILEY
DOI: 10.1111/cas.15796
Keywords
cell survival; linear quadratic model; predictive model; radiation; radiobiology
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The study found that the linear quadratic (LQ) model, which is commonly used in radiobiological modeling, suffers from nonmonotonic behavior and poor extrapolation. It also leads to unrealistic predictions with negative beta values. In comparison, the power model and the linear model perform better in cross-validation. Therefore, the LQ model is not a valid predictive dose-response model for cell survival and alternative models need to be investigated.
The linear quadratic (LQ) model has been the dominant tool in preclinical radiobiological modeling of cell survival as a function of dose. However, as a second-order polynomial approximation, it suffers from two well-known pitfalls: nonmonotonic behavior and poor extrapolation. This study examined the raw data of 253 sets of photons and 943 sets of the ion beam from the Particle Irradiation Data Ensemble (PIDE) project to understand how often the LQ model could result in a negative beta, which would give unrealistic predictions. Additionally, the predictive performance of the LQ model, the power model, and the linear model's predictive performance was studied using leave-one-out cross-validation (LOOCV) and twofold cross-validation. It was found that, when fitted to the LQ model, 7.5% of the photon and 29.8% of the ion beam dose-response data would result in negative beta, compared to 0.77% and 2.0%, respectively, reported in published works. The LQ model performed poorly in LOOCV compared to the alternative power model, and performed the worst among the three models in twofold cross-validation. The LQ model leads to unrealistic parameters, which are vastly under-reported in published studies, and performs poorly in standard cross-validation tests. Therefore, the LQ model is not a valid predictive dose-response model for cell survival. Alternative models need to be investigated.
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