Related references
Note: Only part of the references are listed.
Article
Biochemistry & Molecular Biology
Bo Zhang et al.
Summary: The impact of anesthetic management on the prognosis of cancer patients undergoing surgery is controversial. This study showed that propofol, a specific type of anesthetic, promotes cancer cell metastasis by inhibiting ferroptosis through the Nrf2 pathway. These findings have implications for the choice of anesthetic during tumor surgery.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hind Bouchaoui et al.
Summary: Ferroptosis, an iron-dependent regulated cell death triggered by high lipid peroxide levels, has been implicated in neurodegenerative diseases like Parkinson's disease (PD). The exact pathways and conditions leading to the death of dopaminergic neurons in PD remain unknown. This study shows that altering the PUFA composition in dopaminergic neuron membranes can determine susceptibility to ferroptosis, and cotreatment with iron promotes lipid peroxidation and cell death. Inhibition of specific enzymes involved in the lipid peroxidation pathway could be potential targets for neuroprotective strategies in PD.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Claire Conche et al.
Summary: Investigating the effect of ferroptosis in the tumour microenvironment, specifically focusing on liver cancer, to identify potential combinatory therapies. The study genetically altered GPx4 in mouse models for hepatocellular carcinoma and colorectal cancer to analyze the impact of ferroptosis on tumor cells and the immune response. The findings revealed a context-specific ferroptosis-induced immune response that could be used in the treatment of liver tumors and liver metastases.
Review
Cell Biology
Liyan Deng et al.
Summary: Inflammation is a defensive response to irritation and is involved in various diseases. Ferroptosis, a type of cell death regulated by multiple cellular metabolic pathways, has been found to be associated with inflammation. Targeting ferroptosis shows great prospects in preventing and treating inflammatory diseases.
INFLAMMATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Vincent Wai-Hin Yuen et al.
Summary: This study aims to investigate how genetic composition and specific oncogenic pathways regulate the immune composition of hepatocellular carcinoma (HCC) and affect the response to immune checkpoint inhibitors (ICIs). By establishing mouse models with genetic genotypes similar to human HCCs using genome-editing techniques, the researchers found that "hot tumors" driven by genetic mutations responded well to anti-PD-1 treatment, while "cold tumors" did not. In addition, they discovered that the TKI sorafenib can enhance the sensitivity of "cold tumors" caused by certain genetic mutations to anti-PD-1 treatment.
JOURNAL OF HEPATOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Dong Liu et al.
Summary: Emerging evidence indicates that tryptophan metabolism serves as a new anti-ferroptotic pathway to promote tumor growth. Tryptophan metabolites serotonin and 3-hydroxyanthranilic acid act as potent radical trapping antioxidants to inhibit ferroptotic cell death. Monoamine oxidase A degrades serotonin and deficiency of MAOA renders cancer cells resistant to ferroptosis. Kynureninase confers cells resistance to ferroptotic cell death, while 3-hydroxyanthranilate 3,4-dioxygenase blocks ferroptosis inhibition by consuming 3-HA. In addition, the expression level of HAAO is positively correlated with lipid peroxidation and clinical outcome.
Article
Engineering, Environmental
Xin Qin et al.
Summary: Electro-Fenton (e-Fenton) is a promising method for wastewater treatment by generating powerful .OH through the decomposition of electro-generated H2O2 catalyzed by Fe2+. However, developing a catalyst capable of simultaneously producing H2O2 and accelerating Fe2+ regeneration remains a challenge. In this study, a hollow porous carbon sphere catalyst (HPCS) was developed to enhance H2O2 generation and Fe3+/Fe2+ cycling by constructing an electron-rich microenvironment via surface curvature regulation. The HPCS-TPOS catalyst with a larger curvature structure showed higher Fe2+ regeneration efficiency (35.5%) compared to the HPCS-S catalyst (22.8%). The HPCS-TPOS also exhibited a higher H2O2 production rate (47.2 mmol L-1 h-1) surpassing state-of-the-art e-Fenton catalysts. These findings provide new insights into the design of efficient catalysts for wastewater treatment by regulating curvature structures.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Medicine, Research & Experimental
Yi Xu et al.
Summary: This study demonstrated the induction of ferroptosis in BC cells by AA both in vitro and in vivo. AA showed synergistic effects with chemotherapeutic agents and inhibited the growth of BC cells. These findings suggest that AA could be a promising agent for the treatment of BC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Yu Mi et al.
Summary: UVB-induced oxidative stress may enhance the sensitivity of lens epithelial cells to ferroptotic stress, leading to age-related cataracts.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Shunv Cai et al.
Summary: Trabectedin induces ferroptosis in non-small cell lung cancer cells through upregulating iron, reactive oxygen species, and lipid peroxidation. This finding suggests the potential of trabectedin as an effective treatment for NSCLC.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Biochemistry & Molecular Biology
Raphae Rodriguez et al.
Summary: Ferroptosis is a unique type of non-apoptotic cell death that occurs due to the unrestrained peroxidation of phospholipids, resulting in the production of lethal oxygen radicals mediated by iron. It has been observed in various organisms, including mammals, where it can serve as a defense mechanism against pathogens and be utilized by T cells for effective killing of tumor cells. Conversely, ferroptosis is considered to be one of the main cell death mechanisms contributing to degenerative diseases. Recent studies suggest that certain cancers exhibit vulnerabilities to ferroptosis, particularly in dedifferentiating and persister cancer cells that are dependent on iron. Exploiting this dependence on iron may hold therapeutic benefits.
Article
Cell Biology
Deng Guan et al.
Summary: Research revealed that DpdtbA resisted TGF-beta 1-induced EMT through ferritinophagy-mediated ROS production, promoting EMT inhibition. Additionally, activation of Nrf2 played a role in regulating the cellular redox environment changes.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Jong-Jer Lee et al.
Summary: This study demonstrates that 5-LOX plays a crucial role in ROS-induced cell death in the retinal pigment epithelium (RPE). The inhibition of 5-LOX activity can alleviate ROS-induced damage and promote retinal cell survival.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Nutrition & Dietetics
Eikan Mishima et al.
Summary: Ferroptosis is a regulated cell death process characterized by excessive lipid peroxidation of cellular membranes caused by disruption of the antioxidant defense system and/or imbalanced cellular metabolism. Unlike other forms of regulated cell death, the sensitivity of cells to lipid peroxidation and ferroptosis is directly regulated by various metabolic pathways and nutritional aspects. The hallmarks of ferroptosis have been observed in various diseases, making the modulation of ferroptosis a potential therapeutic approach.
ANNUAL REVIEW OF NUTRITION
(2022)
Article
Oncology
Ngoc T. Vu et al.
Summary: This study reveals that CERK inhibition induces ferroptosis in mutant KRAS NSCLC cells by modulating VDAC, leading to reduced cell survival. Additionally, CERK inhibition synergizes with cisplatin to inhibit in vivo tumor growth in NSCLC.
MOLECULAR CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Santhi Latha Pandrangi et al.
Summary: This paper discusses the importance of iron in regulating cell death in tumor cells and cancer stem cells, as well as the molecular characteristics of iron-induced ferroptosis and apoptosis.
Review
Biochemistry & Molecular Biology
Guo-Wei Qiu et al.
Summary: This article reviews the iron acquisition pathways utilized by cyanobacteria to overcome the challenges of low concentrations and poor bioavailability of certain iron species. It highlights that cyanobacteria not only increase iron fluxes through transport, but also employ behavioral traits and intricate interactions with bacteria to address iron scarcity.
TRENDS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Bao Liu et al.
Summary: The study successfully developed a novel targeted drug delivery system for enhancing immunotherapy of drug-resistant GBM and demonstrated its significant inhibitory effect on tumor growth and prolonged survival time in mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xumin Zhou et al.
Summary: This study demonstrates that HnRNP L knockdown decreases PD-L1 expression, restores cancer cell sensitivity to T-cell killing, and enhances antitumor immunity in castration-resistant prostate cancer (CRPC). The findings suggest that targeting HnRNP L may be a novel therapeutic strategy to improve the efficacy of PD-1/PD-L1 blockade and promote an immune response against CRPC.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Zaihuan Lin et al.
Summary: In this study, we found that HIF-1α promotes the stability of SLC7A11 by upregulating lncRNA-PMAN, thereby inhibiting iron overload in GC cells. These findings provide theoretical support for the identification of diagnostic biomarkers and therapeutic targets for peritoneal metastasis in gastric cancer.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi et al.
Summary: Patient outcomes from current cancer therapy are unsatisfactory, but recent biomedical and nanotechnological advancements have created an opportunity to combine these with conventional treatments. Ferroptosis, an iron-dependent regulated cell death, has been explored for its potential in cancer therapy. This review summarizes the recent developments in ferroptosis-based nanomaterials and discusses the future of ferroptosis, nanomedicine, and cancer therapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chengli Liu et al.
Summary: The study showed that decreased taurine levels in the cerebrospinal fluid of SAH patients could be improved by taurine treatment, leading to amelioration of neurological impairment, oxidative stress, iron accumulation, BBB integrity, and neuronal ferroptosis. Taurine attenuates these effects by regulating the GABAB/AKT/GSK3 beta/beta-catenin signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Shijie Zhan et al.
Summary: Ovarian cancer is a highly lethal gynecological cancer due to the lack of effective early diagnosis and treatment for chemoresistance and metastasis. The lipid-enriched microenvironment in the peritoneal fluid has been found to promote metabolic reprogramming in metastatic ovarian cancer cells, using free fatty acids as the main energy source. Inducing ferroptosis, a form of programmed cell death, may be a viable target to prevent cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Xuhui Tong et al.
Summary: This article discusses the molecular processes and effects of necroptosis, pyroptosis, ferroptosis, and cuproptosis on tumor cell proliferation and cancer metastasis, as well as the complex effects of these novel types of tumor cell death on the tumor microenvironment and regulated death of other cells in the microenvironment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Kerong Chen et al.
Summary: A new nanocomplex is developed in this study to trigger ferroptosis and photodynamic therapy, showing potential anti-tumor effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Rina Kim et al.
Summary: Ferroptosis is a unique and targetable immunosuppressive mechanism in the tumor microenvironment, which can be pharmacologically modulated to limit tumor progression. It induces spontaneous death of PMN-MDSCs in the tumor microenvironment and limits the activity of human and mouse T cells.
Article
Cell Biology
Shicheng Sun et al.
Summary: This study investigates the role of hypoxia in SAS-induced ferroptosis in glioma. Hypoxia suppresses SAS-induced ferroptosis by upregulating SLC7A11 expression through the activation of the PI3K/AKT/HIF-1 alpha pathway. The combination therapy of PX-478 and SAS shows a synergistic effect in inhibiting glioma growth in vivo. Therefore, targeting hypoxia and using combination therapy may be a potential strategy against glioma.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Yi Liu et al.
Summary: This study identified the involvement of Uhrf1 in mediating ferroptosis of chemically injured AEC2 cells through de novo promoter-specific methylation of GPX4 and FSP1 genes, thus accelerating the process of pulmonary fibrosis. Inhibition of Uhrf1 can prevent the formation of ferroptosis and block the progression of pulmonary fibrosis.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Qin Dang et al.
Summary: Ferroptosis is an unconventional iron-dependent programmed cell death that has significant implications in treating drug-resistant cancers and modulating immune tolerance.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Zhi Lin et al.
Summary: This study reveals the role of the lipid flippase SLC47A1 in ferroptosis, providing a metabolic target for overcoming drug resistance.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Changmei Yang et al.
Summary: In this study, we found that 4,4'-dimethoxychalcone (DMC) induces ferroptosis in cancer cells by activating the Keap1/Nrf2/HMOX1 pathway and inhibiting ferrochelatase (FECH). These findings shed light on the mechanisms of DMC in inhibiting cancer cell growth and provide a new insight into the biological functions of flavonoids.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Nutrition & Dietetics
Xu Yang et al.
Summary: This review summarizes the impact of iron on male reproductive functions and the mechanism of testicular ferroptosis, aiming to provide a theoretical basis for understanding the relationship between ferroptosis and male reproductive function.
Review
Immunology
Xiaowen Qi et al.
Summary: This article presents the characteristics of breast cancer and the importance of ferroptosis in tumor treatment, emphasizing the hope of reversing tumor resistance and improving treatment outcomes through inducing ferroptosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Materials Science, Biomaterials
Seong Dong Jeong et al.
Summary: This study reports a tannic acid (TA)-Fe3+-coated doxorubicin (DOX)-encapsulated micelle for inducing immunogenic cell death (ICD) through apoptosis/ferroptosis pathways. The in vivo results show that the combination treatment considerably inhibits tumor growth and improves antitumor immunity.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Shuang Wang et al.
Summary: Dioscin exerts a renoprotective effect by reducing oxidative injury, apoptosis, and ferroptosis in the kidneys through the Nrf2/HO-1 signaling pathway, providing new insights into the prevention of acute kidney injury.
Article
Cell Biology
Zhuo Gao et al.
Summary: The present study demonstrated that Lys treatment induced ferroptosis to exert antitumor effects in HCT116 and SW480 CRC cells by modulating Nrf2 signaling.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Cell Biology
Yunxi Du et al.
Summary: Ferroptosis is a new iron-dependent form of programmed cell death, closely related to the pathophysiological processes of many diseases. Recent studies have identified key targets and regulators, which are of great significance for related research.
CELL DEATH DISCOVERY
(2022)
Review
Endocrinology & Metabolism
Mengmeng Ou et al.
Summary: This review discusses the role and regulatory mechanisms of ferroptosis in neurological diseases. Current research mainly focuses on the key pathways of ferroptosis, and it has been found that ferroptosis plays a bidirectional regulatory role in neurological diseases. However, further exploration is needed to uncover the specific regulatory mechanisms of ferroptosis in neurological diseases.
MOLECULAR METABOLISM
(2022)
Article
Oncology
Alhasan Alsalman et al.
Summary: This study provides evidence of associations between different CD8(+) T cell subsets and disease-free survival (DFS) in colorectal cancer (CRC) patients. The study found that higher levels of certain circulating and tumor-infiltrating CD8(+) T cell subsets were associated with improved clinical outcomes in CRC patients.
Article
Chemistry, Multidisciplinary
Luwen Zhu et al.
Summary: This study describes the fabrication of a ferritin-hijacking nanoparticle that can induce endogenous ferroptosis without introducing Fenton-reactive metals. The nanoparticle specifically accumulates around ferritin and generates reactive oxygen species upon laser irradiation, leading to the destruction of ferritin, activation of endogenous ferroptosis, and direct killing of tumor cells. The released iron from ferritin further enhances photodynamic therapy and amplifies oxidative stress.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Yangsook Song Green et al.
Summary: This study found that targeting ISCA2 protein can reduce HIF-1/2 alpha protein levels and inhibit the development of clear cell renal cell carcinoma (ccRCC) by inducing ferroptosis. ISCA2 inhibition not only decreases HIF-2 alpha protein levels by blocking IRE-dependent translation, but can also reduce HIF-1 alpha translation at higher concentrations through unknown mechanisms. Additionally, ISCA2 inhibition triggers the iron starvation response, leading to iron/metals overload and cell death.
Article
Cell Biology
Xiaodong Su et al.
Summary: This study discovered that enhancing HIF signals can induce ferroptosis in chemoresistant GBM cells, leading to suppressed tumor growth. The effectiveness of this method was further confirmed in vivo, providing new approaches to improve GBM treatment.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Yuying Han et al.
Summary: Ferroptosis, a regulated cell death induced by iron-dependent lipid peroxidation, is important in tumor development and drug resistance. In this study, we found that LINC00239 is significantly overexpressed in colorectal cancer (CRC) tissues and its high expression predicts poorer survival and prognosis in CRC patients. We also demonstrated that LINC00239 inhibits ferroptosis, decreasing the anti-tumor activity of certain drugs. Importantly, LINC00239 interacts with Keap1 to regulate ferroptosis, suggesting a potential therapeutic strategy for CRC patients with low LINC00239 expression.
CELL DEATH & DISEASE
(2022)
Article
Cell & Tissue Engineering
Huan Feng et al.
Summary: The study demonstrates that HUCMSCs can effectively and safely alleviate erectile dysfunction in T1DM and T2DM ED rats by attenuating diabetes-induced ferroptosis in CCSMCs. Furthermore, it provides significant evidence for the development of HUCMSCs as a viable therapeutic strategy for DMED.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Pharmacology & Pharmacy
Kai Sun et al.
Summary: This review discusses the importance of ferritinophagy in ferroptosis and autophagy, as well as its role in cancer development. The studies provide new insights into the mechanisms of ferritinophagy and promising treatments for cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yusong Luo et al.
Summary: Glioma is a common intracranial malignant tumor and current treatment options are not very effective. Recently, a new form of cell death called ferroptosis has been discovered, which plays a significant role in the treatment of gliomas.
Review
Cell Biology
Tianyu Ma et al.
Summary: Ferroptosis is a form of cell death characterized by iron accumulation and lipid peroxidation, with GPX4 playing a crucial role in regulating this process. However, researchers have identified alternative pathways independent of GPX4 in ferroptosis. Studying these independent pathways can provide better insights into preventing and treating related diseases.
CELL DEATH DISCOVERY
(2022)
Review
Cell Biology
Deting Gong et al.
Summary: Ferroptosis, triggered by intracellular iron, leads to cell death through the accumulation of lipid peroxidation. Cancer cells can evade ferroptosis by activating antioxidant signaling pathways. Besides transcriptional regulation, ferroptosis can also be modulated by ubiquitination or autophagic degradation. Induction of ferroptosis enhances immune cell activity, but it may impair T cell activity as well. Therefore, rational combined therapy is crucial for cancer treatment.
CELL DEATH DISCOVERY
(2022)
Article
Obstetrics & Gynecology
Xiaodong Wu et al.
Summary: The study evaluated the expression levels of SLC7A11 and GPX4 in relation to platinum resistance and prognosis in patients with epithelial ovarian cancer (EOC). The results showed that high co-expression of SLC7A11 and GPX4 was associated with an increased risk of platinum resistance and poor prognosis. Additionally, inhibition of SLC7A11 and GPX4 decreased platinum resistance.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Cell Biology
Xin Chen et al.
Summary: Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation. Lipoxygenase is the main promoter of ferroptosis, while GPX4 is the central repressor of this process.
Review
Biology
Jianlin Zhang et al.
Summary: Ferritin, a vital iron-storage protein, plays a key role in regulating cellular iron metabolism and oxidative stress. It forms a unique spherical cage structure to safely store iron and prevent oxidative damage. The expression of ferritin is regulated by iron status and oxidative stress, and it functions by catalyzing oxidation and mediating iron recycling within cells.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Leng Han et al.
Summary: The study shows that elevated ferroptosis impairs the maturation and function of dendritic cells (DCs), limiting their role in antitumor immunity. However, genetic depletion of PPARG restores the function of DCs, enhancing their antitumor immune activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xiang Luo et al.
Summary: This study establishes a novel pathway for the phagocytic clearance of ferroptotic cells and identifies key molecules involved in the process. The results demonstrate that SAPE-OOH on the surface of ferroptotic cells acts as an eat-me signal and initiates phagocytosis by macrophages through TLR2 recognition.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Cell Biology
Daolin Tang et al.
Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.
Review
Biochemistry & Molecular Biology
Golnaz Morad et al.
Summary: This passage discusses the unprecedented advances in cancer treatment with immune checkpoint blockade (ICB), highlighting the critical need for insights into factors intrinsic and extrinsic to the host that impact ICB response and toxicity. There has been substantial progress in understanding the impact of host-intrinsic factors and the exposome on host physiology and response to treatment, representing the hallmarks of response, resistance, and toxicity to ICB in current day.
Article
Oncology
Xin Hong et al.
Summary: Circulating tumor cells shed by cancer into the bloodstream coordinately upregulate lipogenesis and iron homeostasis pathways, contributing to resistance to BRAF inhibitors. The lipogenesis regulator SREBP2 induces transcription of iron carrier TF, reducing oxidative stress and conferring resistance to ferroptosis inducers. Presence of CTCs with high lipogenic and iron metabolic signatures is correlated with adverse clinical outcome in melanoma patients.
Article
Oncology
Jefte M. Drijvers et al.
Summary: Metabolic vulnerabilities of CD8(+) T cells and cancer cells were identified through a high-throughput in vitro pharmacologic screening platform, with CD8(+) T cells found to be more sensitive to ferroptosis induction. The screening platform may also be useful for rapid testing of compounds targeting antitumor CD8(+) T-cell function and potential therapeutic targets.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Huabin Zhu et al.
Summary: MDSCs are immune suppressive cells that accumulate in pathological conditions to suppress T cell immune response. ASAH2 is highly expressed in tumor-infiltrating MDSCs and acts as a survival factor, targeting ASAH2 can induce MDSC ferroptosis to suppress MDSC accumulation in cancer immunotherapy.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Oncology
Xin Chen et al.
Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Cell Biology
Jiawen Yang et al.
Summary: This study demonstrates that cetuximab enhances the cytotoxic effect of RSL3 on KRAS mutant CRC cells by regulating the p38/Nrf2/HO-1 axis to promote ferroptosis. These findings suggest a potential strategy to overcome drug resistance in KRAS mutant colorectal cancer.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Zhang-Wei Hu et al.
Summary: The study found different expression regulation of FTL and FTH1 in various human cancers, which were associated with patient prognosis and tumor-infiltrating immune cells, suggesting their important role in regulating tumor immunity to solid cancers.
Article
Cell Biology
Sophie M. Poznanski et al.
Summary: NK cells play a central role in anti-tumor immunity, but their dysfunction in the tumor microenvironment is a major barrier for cancer immunotherapies. Research showed that human NK cell dysfunction in the tumor microenvironment is caused by suppression of glucose metabolism, and activating the antioxidant pathway can restore NK cell function and enhance anti-tumor activity. Additionally, expanded NK cells with metabolic flexibility not only sustained metabolic fitness but also improved tumor killing in response to nutrient deprivation, showing the potential for exploiting metabolic flexibility in cancer immunotherapy.
Article
Biochemistry & Molecular Biology
Thais Oliveira et al.
Summary: Epithelial-to-mesenchymal transition (EMT) is a crucial process in development and wound healing, but it can also contribute to the progression and spread of aggressive tumors in cancer, as well as increase resistance to therapy. This study used the SW13 cell line to investigate the connection between iron metabolism and EMT, finding that HDAC inhibitor treatment led to increased iron accumulation, reduced expression of iron export proteins, and enhanced sensitivity to a form of iron-mediated cell death called ferroptosis. These findings suggest potential implications for improving iron-targeted chemotherapeutic strategies in cancer treatment.
Review
Immunology
Samarth Hegde et al.
Summary: MDSCs are a widely discussed biological entity in immunology, commonly describing cells that arise during chronic inflammation with T cell immunosuppressive functions. Currently lacking clear definitions and a unifying framework across pathologies, we propose a framework based on activation signals to classify MDSCs as discrete cell states. Developing this knowledge of myeloid states across pathological conditions may transform how diseases are grouped and treated.
Article
Medicine, Research & Experimental
Zhou Jiang et al.
Summary: Research shows that tumors with high TYRO3 expression exhibit resistance to PD-1/PD-L1 therapy by inhibiting tumor cell ferroptosis and altering the tumor microenvironment. Inhibition of TYRO3 promotes tumor ferroptosis and sensitizes resistant tumors to PD-1 therapy. This suggests that TYRO3 could be a predictive biomarker for patient selection and a promising therapeutic target to overcome resistance to PD-1/PD-L1 therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Fuwen Yao et al.
Summary: The study showed that high expression of hub FRGs in gastric cancer is associated with poor overall survival in patients, with CD4(+) T cells being the major infiltrated cells in the tumor microenvironment. Furthermore, the hub FRGs are significantly correlated with activated CD4(+) T cell infiltration, suggesting their potential role in mediating CD4(+) T cell activation through various signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Jing Wu et al.
Summary: This review outlines the characteristics of ferroptosis, its relevance in liver diseases, and the molecular mechanisms underlying common liver diseases. Challenges and promises for future investigations in ferroptosis regulation as a potential therapeutic target in clinical practice are also highlighted.
CELL DEATH DISCOVERY
(2021)
Review
Oncology
Shangli Zhu et al.
Summary: Macrophages are heterogeneous cells that can be classified into M1- and M2-like phenotypes, with M2-like macrophages playing a critical role in tumor microenvironment. They contribute to tumor progression by promoting tumor cell proliferation, angiogenesis, and immunosuppression.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Rundi Song et al.
Summary: Researchers have developed a immunotherapy method that enhances the immunogenicity of tumor cells by inducing ferroptosis, thereby improving the efficacy of cancer immunotherapy.
ADVANCED MATERIALS
(2021)
Article
Cell Biology
Emeline Dierge et al.
Summary: Excess uptake of specific polyunsaturated fatty acids can selectively induce ferroptosis in cancer cells under acidic conditions, potentially serving as an adjuvant antitumor modality to complement pharmacological approaches.
Review
Biochemistry & Molecular Biology
Vittoria Infantino et al.
Summary: In cancer cells, metabolic reprogramming under low-oxygen conditions is crucial for tumor survival, with HIF-1 playing a pivotal role. Mitochondria are key players in regulating cellular energy and closely interact with HIF-1 to drive metabolic and functional changes in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Zhengying Gu et al.
Summary: This study demonstrates that an iron-based metal organic framework nanoparticle and a ferroptosis-inducing agent synergistically induce mitochondrial alternation in TAMs, resulting in a radical metabolic switch from mitochondrial oxidative phosphorylation to glycolysis, which is resistant to anti-inflammatory stimuli challenge. The ferroptosis stress strengthened by the nanoformulation also drives multiple pro-inflammatory signaling pathways, enabling macrophage activation with potent tumoricidal activities. The ferroptosis-strengthened macrophage regulation strategy present in this study paves the way for TAM-centered antitumoral treatment to overcome the limitations of conventional methods.
Article
Cell Biology
Yanchun Li et al.
Summary: CISD3 plays a crucial regulatory role in cancer progression and ferroptosis, with its overexpression associated with poorer survival rates, while its depletion accelerates ferroptotic cell death. Depletion of CISD3 leads to metabolic reprogramming towards glutaminolysis, which is essential for mitochondrial oxidative phosphorylation.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Chengxian Xu et al.
Summary: Research shows that Gpx4 plays a crucial role in protecting Treg cells from lipid peroxidation and ferroptosis, regulating immune homeostasis and antitumor immunity. Deletion of Gpx4 can lead to lipid peroxidation and ferroptosis of Treg cells, affecting immune homeostasis and antitumor immunity. Neutralization of lipid peroxides and blockade of iron availability rescue ferroptosis of Gpx4-deficient Treg cells.
Article
Medicine, Research & Experimental
Chih-Hsiung Hsieh et al.
Summary: This study demonstrates the dual properties of zero-valent-iron nanoparticles (ZVI-NP) in inducing cancer-specific cytotoxicity and anti-cancer immunity, highlighting their potential as an advanced integrated anti-cancer strategy. ZVI-NP not only induces cancer cell death but also enhances the anti-tumor immune response in animal models.
Article
Oncology
Xianlin Yi et al.
Summary: The study reveals differences in lipid metabolism in exosomes of hormone-sensitive and hormone-resistant prostate cancer cells, indicating potential for lipid-based biomarker screening. Phospholipids show varying compositions in exosomes from different cells, highlighting the importance of phosphatidylcholine and lysophosphatidylcholine in hormone-sensitive prostate cancer. Targeting lysophosphatidylcholine, autophagy, and ferroptosis pathways may offer new therapeutic strategies. The modified PEG precipitation technique shows promise for isolating prostate cancer cell exosomes for cancer screening.
Article
Cell Biology
Enyong Dai et al.
Article
Biochemistry & Molecular Biology
Alexandr A. Kapralov et al.
NATURE CHEMICAL BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Kewen Hu et al.
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Review
Oncology
Lorenzo Galluzzi et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Review
Cell Biology
Jing Yang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Sebastian Mueller et al.
Article
Chemistry, Multidisciplinary
Lisen Lin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Multidisciplinary Sciences
Julia I-Ju Leu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Enyong Dai et al.
NATURE COMMUNICATIONS
(2020)
Review
Pharmacology & Pharmacy
Amber M. Johnson et al.
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Oncology
Iuliia Efimova et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Review
Biochemistry & Molecular Biology
Caroline C. Philpott et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Annadurai Anandhan et al.
CELL CHEMICAL BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Izumi Yanatori et al.
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Toxicology
Christine Wenz et al.
ARCHIVES OF TOXICOLOGY
(2019)
Article
Multidisciplinary Sciences
Weimin Wang et al.
Article
Multidisciplinary Sciences
Jiao Wu et al.
Article
Cell Biology
Jianling Bi et al.
CELL DEATH & DISEASE
(2019)
Article
Oncology
Xueting Lang et al.
Article
Multidisciplinary Sciences
Kirill Bersuker et al.
Article
Biochemistry & Molecular Biology
Minghui Gao et al.
Review
Oncology
Montserrat Rojo de la Vega et al.
Review
Cell Biology
Hani Choudhry et al.
Review
Biochemistry & Molecular Biology
Jente van Staalduinen et al.
Article
Biochemistry & Molecular Biology
Huizhong Feng et al.
Review
Oncology
Meagan B. Ryan et al.
NATURE REVIEWS CLINICAL ONCOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Evan H. Baugh et al.
CELL DEATH AND DIFFERENTIATION
(2018)
Article
Cell Biology
Yanhong Zhang et al.
GENES & DEVELOPMENT
(2017)
Article
Cell Biology
Caitlin W. Brown et al.
JOURNAL OF CELL BIOLOGY
(2017)
Review
Multidisciplinary Sciences
Daniel S. Chen et al.
Article
Multidisciplinary Sciences
Vasanthi S. Viswanathan et al.
Article
Cell Biology
Ioannis Poursaitidis et al.
Review
Biochemistry & Molecular Biology
C. B. Medina et al.
CELL DEATH AND DIFFERENTIATION
(2016)
Article
Cell Biology
Matthew Jennis et al.
GENES & DEVELOPMENT
(2016)
Article
Biochemistry & Molecular Biology
Juan R. Cubillos-Ruiz et al.
Article
Immunology
Mai Matsushita et al.
JOURNAL OF EXPERIMENTAL MEDICINE
(2015)
Article
Multidisciplinary Sciences
Le Jiang et al.
Article
Biochemistry & Molecular Biology
Scott J. Dixon et al.
Article
Biochemistry & Molecular Biology
Wan Seok Yang et al.
CHEMISTRY & BIOLOGY
(2008)
