Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 68, Issue 25, Pages 2850-2870Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2016.09.972
Keywords
diabetes mellitus; diagnostics; energy metabolism; heart failure; ischemic heart disease; obesity
Categories
Funding
- American Heart Association [4FTF20440012]
- Massachusetts General Hospital Heart Center Hassenfeld Scholar Award
- NIH [R01-DK081572]
- Heart and Stroke Foundation of Canada
- CDA
- Canadian Institutes for Health Research
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Perturbations in cardiac energy metabolism are major contributors to a number of cardiovascular pathologies. In addition, comorbidities associated with cardiovascular disease (CVD) can alter systemic and myocardial metabolism, often contributing to the worsening of cardiac function and health outcomes. State-of-the-art metabolomic technologies give us the ability to measure thousands of metabolites in biological fluids or biopsies, providing us with a metabolic fingerprint of individual patients. These metabolic profiles may serve as diagnostic and/or prognostic tools that have the potential to significantly alter the management of CVD. Herein, the authors review how metabolomics can assist in the interpretation of perturbed metabolic processes, and how this has improved our ability to understand the pathology of ischemic heart disease, atherosclerosis, and heart failure. Taken together, the integration of metabolomics with other omics platforms will allow us to gain insight into pathophysiological interactions of metabolites, proteins, genes, and disease states, while advancing personalized medicine. (C) 2016 by the American College of Cardiology Foundation.
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