ELECTROCHEMICAL SENSOR OF MULTIWALLED CARBON NANOTUBE ELECTRODE MODIFIED BY 1-PHENYL-3-METHYL-4-ORTHOFLUORO BENZOYL-5-PYRAZOLONE FOR SENSING DOPAMINE

This work explicates a simple, rapid, and sensitive method for the electrochemical detection of dopamine (DOP) utilising 1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone (HPMoFBP)/multiwalled carbon nanotube (MWCNT) carbon paste electrode (CPE). The electrochemical behaviour of DOP was performed through cyclic voltammetry and square wave voltammetry. HPMoFBP/MWCNT showed a higher current at the lower potential for the oxidation of DOP compared to bare MWCNT. The sensor's improved electrocatalytic activity was observed to detect in a 1.0 x 10-1 M phosphate buffer saline (PBS) solution at pH 8.0. A good linear regression analysis was observed between electrical response and the concentration of DOP in the range of 1 to 1000 mu M. Under optimized experimental conditions, 1.0 x 10-7 M has been determined as the limit of detection (LOD). The sensor has expressed considerable sensitivity towards DOP detection without interference and is successfully used to determine DOP in dopamine hydrochloride injection.

Automated summary

This study presents a simple, rapid, and sensitive method for electrochemical detection of dopamine using 1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone/multiwalled carbon nanotube carbon paste electrode. Cyclic voltammetry and square wave voltammetry were used to investigate the electrochemical behavior of dopamine. HPMoFBP/MWCNT showed enhanced electrocatalytic activity for dopamine oxidation compared to bare MWCNT. The sensor exhibited good linearity between electrical response and dopamine concentration in the range of 1 to 1000 mu M, with a limit of detection of 1.0 x 10-7 M.