The Role of P2Y6 Receptors in the Mechanisms of the Neuroprotective Effect of Citicoline

Spontaneous bioelectrical activity of the brain and the duration of gasping were recorded in mice during modeling of global strangulation ischemia of the brain against the background of preventive administration of citicoline. The maximum neuroprotective effect of citicoline was observed when it was administered 60 min before the simulation of ischemia and was completely prevented by preliminary administration of a selective P2Y6 receptor antagonist MRS2578. The obtained experimental data attest to the leading role of receptor mechanisms in the implementation of neuroprotective activity of citicoline.

Automated summary

This study observed the effect of pre-administration of citicoline on spontaneous bioelectrical activity and gasping duration in mice during global strangulation ischemia of the brain. The results showed that citicoline exhibited the maximum neuroprotective effect when administered 60 min before ischemia simulation and this effect was completely prevented by pre-administration of a selective P2Y6 receptor antagonist, MRS2578. The experimental data suggest the leading role of receptor mechanisms in the neuroprotective activity of citicoline.