Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 67, Issue 18, Pages 2161-2176Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2016.01.083
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The prospect of changing the plasticity of terminally differentiated cells toward pluripotency has completely altered the outlook for biomedical research. Human-induced pluripotent stem cells (iPSCs) provide a new source of therapeutic cells free from the ethical issues or immune barriers of human embryonic stem cells. iPSCs also confer considerable advantages over conventional methods of studying human diseases. Since its advent, iPSC technology has expanded with 3 major applications: disease modeling, regenerative therapy, and drug discovery. Here we discuss, in a comprehensive manner, the recent advances in iPSC technology in relation to basic, clinical, and population health. (C) 2016 by the American College of Cardiology Foundation.
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