Ichthyotic skin phenotype induced by the chronic activation of Toll-like receptor 2, and autoinflammation

We read with great interest 'Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype' by Tagoe et al. Their findings expand our recent understanding of how certain kinds of autoinflammation contribute to the pathogenesis of ichthyosis. Inspired by the report by Tagoe et al., we suggest that their unique autosomal recessive congenital ichthyosis in vitro models have several characteristics in common with autoinflammatory keratinization diseases.

Automated summary

This article summarizes the study by Tagoe et al., in which they found that chronic activation of Toll-like receptor 2 leads to the development of ichthyotic skin phenotype. Their findings extend our understanding of the pathogenesis of ichthyosis caused by certain types of autoinflammation. Inspired by Tagoe et al.'s report, we suggest that their unique autosomal recessive congenital ichthyosis in vitro models share similarities with autoinflammatory keratinization diseases.