Journal
BRITISH JOURNAL OF DERMATOLOGY
Volume 188, Issue 5, Pages 601-609Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bjd/ljad010
Keywords
-
Categories
Ask authors/readers for more resources
65% of patients with moderate-to-severe hidradenitis suppurativa achieved a clinical response after 16 weeks of guselkumab treatment, which was well tolerated. Transcriptomic data supported the rationale for IL-23 inhibition with guselkumab, but did not consistently correlate with protein expression and clinical responses. Guselkumab seems to be beneficial only in a subgroup of HS patients, suggesting that the IL-23/T helper 17 axis is not central to the pathophysiology of HS.
Sixty-five per cent of patients with moderate-to-severe hidradenitis suppurativa (HS) achieved a clinical response after 16 weeks of treatment with guselkumab, which was well tolerated. Transcriptomic data supported the rationale for interleukin (IL)-23 inhibition with guselkumab in HS but did not consistently correlate with protein expression and clinical responses. Guselkumab seems to be of benefit only in a subgroup of patients with HS, indicating that the IL-23/T helper 17 axis is not central to the pathophysiology of HS. Background The effectiveness of available biologics for the treatment of hidradenitis suppurativa (HS) is limited. Additional therapeutic options are needed. Objectives To investigate the efficacy and mode of action of guselkumab [an anti-interleukin (IL)-23p19 monoclonal antibody] 200 mg subcutaneously every 4 weeks for 16 weeks in patients with HS. Methods An open-label, multicentre, phase IIa trial in patients with moderate-to-severe HS was carried out (NCT04061395). The pharmacodynamic response in skin and blood was measured after 16 weeks of treatment. Clinical efficacy was assessed using the Hidradenitis Suppurativa Clinical Response (HiSCR), the International Hidradenitis Suppurativa Severity Score System (IHS4), and the abscess and inflammatory nodule (AN) count. The protocol was reviewed and approved by the local institutional review board (METC 2018/694), and the study was conducted in accordance with good clinical practice guidelines and applicable regulatory requirements. Results Thirteen of 20 patients (65%) achieved HiSCR with a statistically significant decrease in median IHS4 score (from 8.5 to 5.0; P = 0.002) and median AN count (from 6.5 to 4.0; P = 0.002). The overall patient-reported outcomes did not show a similar trend. One serious adverse event, likely to be unrelated to guselkumab treatment, was observed. In lesional skin, transcriptomic analysis revealed the upregulation of various genes associated with inflammation, including immunoglobulins, S100, matrix metalloproteinases, keratin, B-cell and complement genes, which decreased in clinical responders after treatment. Immunohistochemistry revealed a marked decrease in inflammatory markers in clinical responders at week 16. Conclusions Sixty-five per cent of patients with moderate-to-severe HS achieved HiSCR after 16 weeks of treatment with guselkumab. We could not demonstrate a consistent correlation between gene and protein expression and clinical responses. The main limitations of this study were the small sample size and absence of a placebo arm. The large placebo-controlled phase IIb NOVA trial for guselkumab in patients with HS reported a lower HiSCR response of 45.0-50.8% in the treatment group and 38.7% in the placebo group. Guselkumab seems only to be of benefit in a subgroup of patients with HS, indicating that the IL-23/T helper 17 axis is not central to the pathophysiology of HS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available