4.7 Article

Neighbourhood social deprivation and risk of prostate cancer

Journal

BRITISH JOURNAL OF CANCER
Volume 129, Issue 2, Pages 335-345

Publisher

SPRINGERNATURE
DOI: 10.1038/s41416-023-02299-7

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A study found that men living in socially deprived neighborhoods have an increased risk of prostate cancer, with higher risks for those who are divorced, widowed, or living alone. These findings suggest the need for targeted public health interventions.
BackgroundStriking geographic variations in prostate cancer incidence suggest an aetiological role for spatially-distributed factors. We assessed whether neighbourhood social deprivation, which can reflect limited social contacts, unfavourable lifestyle and environmental exposures, is associated with prostate cancer risk.MethodsIn 2005-2012, we recruited 1931 incident prostate cancer cases and 1994 controls in a case-control study in Montreal, Canada. Lifetime residential addresses were linked to an area-based social deprivation index around recruitment (2006) and about 10 years earlier (1996). Logistic regression estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs).ResultsMen residing in areas characterised by greater social deprivation had elevated prostate cancer risks (ORs of 1.54 and 1.60 for recent and past exposures, respectively; highest vs lowest quintiles), independently from area- and individual-level confounders and screening patterns. The increase in risk with recent high social deprivation was particularly elevated for high-grade prostate cancer at diagnosis (OR 1.87, 95% CI 1.32-2.64). Associations were more pronounced for neighbourhoods with higher proportions of separated/divorced or widowed individuals in the past, and with higher percentages of residents living alone recently.ConclusionsThese novel findings, suggesting that neighbourhood-level social deprivation increases the risk of prostate cancer, point out to potential targeted public health interventions.

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