4.5 Article

Using Oncotype DX breast recurrence score® assay to define the role of neoadjuvant endocrine therapy in early-stage hormone receptor-positive breast cancer

Related references

Note: Only part of the references are listed.
Article Oncology

Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study

N. Harbeck et al.

Summary: Adjuvant abemaciclib combined with endocrine therapy significantly improved invasive disease-free survival in patients with early breast cancer, with an acceptable safety profile. Ki-67 index was prognostic but did not affect the benefits of abemaciclib. The robust treatment benefit of abemaciclib extended beyond the planned 2-year treatment period.

ANNALS OF ONCOLOGY (2021)

Article Oncology

Neoadjuvant endocrine therapy use in early stage breast cancer during the covid-19 pandemic

Ko Un Park et al.

Summary: During the COVID-19 pandemic in the US, physicians showed a preference for neoadjuvant endocrine therapy (NET) for ER + BC patients, with an increase in the favor of axillary lymph node dissection (ALND) in cases of low volume metastatic axillary disease as the duration of NET extended.

BREAST CANCER RESEARCH AND TREATMENT (2021)

Article Medicine, General & Internal

21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer

Kevin Kalinsky et al.

Summary: The study showed that among premenopausal women with hormone-receptor-positive, HER2-negative breast cancer and one to three positive lymph nodes with a recurrence score of 25 or lower, the addition of chemotherapy to endocrine therapy led to longer invasive disease-free survival and distant relapse-free survival compared to endocrine therapy alone. However, postmenopausal women with similar characteristics did not benefit from adjuvant chemotherapy in terms of invasive disease-free survival.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Oncology

Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline

Larissa A. Korde et al.

Summary: The guideline recommendations for neoadjuvant therapy for breast cancer suggest that patients should be managed by multidisciplinary teams and that appropriate candidates include those with inflammatory breast cancer or residual disease that may prompt a change in therapy.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Effectiveness of a Short Duration of Neoadjuvant Endocrine Therapy in Patients with HR plus Breast Cancer-An NCDB Analysis (2004-2016)

Macy M. Goldbach et al.

Summary: The study found that short, moderate, and long durations of neoadjuvant endocrine therapy did not result in significant differences in pathologic response, with objective response rates of 56.7%, 52.1%, and 49.0% respectively. For patients with HR+ breast cancer, short-term neoadjuvant endocrine therapy may be a safe and effective way to delay surgery.

ANNALS OF SURGICAL ONCOLOGY (2021)

Review Oncology

Clinical utility of the 21-gene assay in predicting response to neoadjuvant endocrine therapy in breast cancer: A systematic review and meta-analysis

M. G. Davey et al.

Summary: This study aimed to investigate the impact of OncotypeDX Recurrence Score (RS) on patients with ER+/ HER2- breast cancer undergoing neoadjuvant endocrine therapy (NET). The results showed that patients with low to intermediate RS were more likely to respond to NET, while those with high-risk RS were less likely to achieve partial response or conversion to breast conservation surgery.

BREAST (2021)

Article Oncology

MONARCH 2: Subgroup Analysis of Patients Receiving Abemaciclib Plus Fulvestrant as First-Line and Second-Line Therapy for HR+, HER2--Advanced Breast Cancer

Patrick Neven et al.

Summary: Abemaciclib plus fulvestrant demonstrated significant improvements in PFS and OS compared to placebo plus fulvestrant in HR+, HER2(-) advanced breast cancer patients in both first- and second-line treatment subgroups. The benefits were particularly pronounced in patients with primary resistance to endocrine therapy and visceral disease.

CLINICAL CANCER RESEARCH (2021)

Article Medicine, General & Internal

Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer

J. A. Sparano et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Palbociclib and Letrozole in Advanced Breast Cancer

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Oncology

Role of endocrine therapy in the neoadjuvant surgical setting

JM Dixon

ANNALS OF SURGICAL ONCOLOGY (2004)