Localization of depressive symptoms based on focal brain lesions: adding ′resilience′ to ′risk′

Article Biochemistry & Molecular Biology

Increased global integration in the brain after psilocybin therapy for depression

Richard E. Daws et al.

Summary: Psilocybin therapy has the potential to treat depression by increasing brain network integration, according to two clinical trials. The antidepressant response to psilocybin was rapid and sustained, while escitalopram had milder effects on brain network organization.

NATURE MEDICINE (2022)

Add to Collection

Article Psychology, Biological

Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease

Shan H. Siddiqi et al.

Summary: By combining data from lesions, deep brain stimulation and transcranial magnetic stimulation studies, researchers have identified common brain circuitry associated with depression. The connectivity to this circuit predicted the efficacy of antidepressant treatment and the circuits were similar across different datasets. This convergence on a specific brain circuit may represent improved neurostimulation targets for depression and other disorders.

NATURE HUMAN BEHAVIOUR (2021)

Add to Collection

Review Neurosciences