4.4 Article

Serum alpha-CGRP levels are increased in COVID-19 patients with headache indicating an activation of the trigeminal system

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

A framework for manufacturing system reconfiguration and optimisation utilising digital twins and modular artificial intelligence

Gabriel Garate et al.

Summary: The study compared circulating levels of CGRP alpha and CGRP beta in healthy controls and hospitalized COVID-19 patients, and analyzed the impact of comorbidities and treatments on these concentrations. The results showed significantly higher levels of both CGRP isoforms in COVID-19 patients compared to controls, and the presence of arterial hypertension, obesity, or corticosteroid treatment affected the serum concentration of CGRP alpha.

ARCHIVES OF MEDICAL RESEARCH (2023)

Article Clinical Neurology

Salivary CGRP can monitor the different migraine phases: CGRP (in)dependent attacks

Alicia Alpuente et al.

Summary: This study found that salivary CGRP-LI levels were elevated in episodic migraine patients during interictal periods, and usually increased during migraine attacks in most patients. However, not every attack was CGRP-dependent, indicating potential differences in underlying pathophysiology and treatment response.

CEPHALALGIA (2022)

Article Clinical Neurology

Post-COVID-19 persistent headache: A multicentric 9-months follow-up study of 905 patients

David Garcia-Azorin et al.

Summary: The duration of headache during the acute phase of COVID-19 is 2 weeks, but approximately a fifth of patients experience persistent headache following a chronic daily pattern.

CEPHALALGIA (2022)

Article Clinical Neurology

Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19

Karl Messlinger et al.

Summary: Clinical publications consistently show that headache is a common and debilitating symptom in patients with COVID-19, often exhibiting migraine-like characteristics. Studies suggest that activation of the trigeminal nerve may contribute to both headache and anosmia in COVID-19 patients.

CEPHALALGIA (2022)

Letter Gastroenterology & Hepatology

Increase in Serum Calcitonin Gene-Related Peptide β (CGRPβ) Levels in COVID-19 Patients with Diarrhea: An Underlying Mechanism?

Gabriel Garate et al.

DIGESTIVE DISEASES AND SCIENCES (2022)

Article Clinical Neurology

Is Persistent Post-COVID Headache Associated With Protein-Protein Interactions Between Antibodies Against Viral Spike Protein and CGRP Receptor?: A Case Report

Esra Ozkan et al.

Summary: This study reports a severe and long-lasting case of post-COVID headache and the sudden cessation of headache with calcitonin gene-related peptide (CGRP) monoclonal antibody treatment. The study also suggests that the mimicry mechanism between viral proteins and CGRP receptors may explain this phenomenon.

FRONTIERS IN PAIN RESEARCH (2022)

Review Clinical Neurology

How does the brain change in chronic migraine? Developing disease biomarkers

Patricia Pozo-Rosich et al.

Summary: Data from various studies have been utilized to develop chronic migraine biomarkers, which may assist with diagnosis, prognosticating patient outcomes, predicting treatment responses, etc. However, further optimization and validation are still needed.

CEPHALALGIA (2021)

Article Clinical Neurology

HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanism

Hayrunnisa Bolay et al.

Summary: This study investigated the relationship between headache and circulating inflammatory molecules in COVID-19 patients. Results showed significantly elevated levels of HMGB1, NLRP3, ACE2, and IL-6 in the serum of patients with headache, indicating a stronger inflammatory response associated with headache. Additionally, COVID-19 patients with headache exhibited specific clinical characteristics such as increased frequency of pulmonary involvement and higher D-dimer levels.

JOURNAL OF HEADACHE AND PAIN (2021)

Article Multidisciplinary Sciences

Frequency and phenotype of headache in covid-19: a study of 2194 patients

David Garcia-Azorin et al.

Summary: Headache occurred in 23.4% of patients with confirmed COVID-19, being more intense in females. Headache was the most frequent first symptom of COVID-19, with characteristics of being bilateral with pressing quality and typically lasting for 7 days.

SCIENTIFIC REPORTS (2021)

Editorial Material Clinical Neurology

Could CGRP Antagonists Be Helpful in the Fight Against COVID-19?

Carrie E. Robertson

HEADACHE (2020)

Article Clinical Neurology

COVID-19 is a Real Headache!

Hayrunnisa Bolay et al.

HEADACHE (2020)

Article Clinical Neurology

Neurologic manifestations in hospitalized patients with COVID-19 The ALBACOVID registry

Carlos Manuel Romero-Sanchez et al.

NEUROLOGY (2020)

Article Clinical Neurology

Headache associated with COVID-19: Frequency, characteristics and association with anosmia and ageusia

Pedro Augusto Sampaio Rocha-Filho et al.

CEPHALALGIA (2020)

Review Clinical Neurology

Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis

Robin M. van Dongen et al.

CEPHALALGIA (2017)

Article Clinical Neurology

Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine

Eva Cernuda-Morollon et al.

NEUROLOGY (2013)

Article Clinical Neurology

Endothelial progenitor cells A new key for endothelial dysfunction in migraine

Xiana Rodriguez-Osorio et al.

NEUROLOGY (2012)