Application of antibiotic bone cement in the treatment of infected diabetic foot ulcers in type 2 diabetes

BackgroundIn this study, we try to investigate the effect of antibiotic bone cement in patients with infected diabetic foot ulcer (DFU).MethodsThis is a retrospective study, including fifty-two patients with infected DFU who had undergone treated between June 2019 and May 2021. Patients were divided into Polymethylmethacrylate (PMMA) group and control group. 22 patients in PMMA group received antibiotic bone cement and regular wound debridement, and 30 patients in control group received regular wound debridement. Clinical outcomes include the rate of wound healing, duration of healing, duration of wound preparation, rate of amputation, and frequency of debridement procedures.ResultsIn PMMA group, twenty-two patients (100%) had complete wound healing. In control group, twenty-eight patients (93.3%) had wound healing. Compared with control group, PMMA group had fewer frequencies of debridement procedures and shorter duration of wound healing (35.32 +/- 3.77 days vs 44.37 +/- 7.44 days, P < 0.001). PMMA group had five minor amputation, while control group had eight minor amputation and two major amputation. Regarding the rate of limb salvage, there was no limb lose in PMMA group and two limb losses in control group.ConclusionThe application of antibiotic bone cement is an effective solution for infected DFU treatment. It can effectively decreased the frequency of debridement procedures and shorten the healing duration in patients with infected DFU.

Automated summary

This retrospective study investigated the effect of antibiotic bone cement on patients with infected diabetic foot ulcer (DFU). The results showed that compared with the control group, the PMMA group had a higher complete wound healing rate, fewer frequencies of debridement procedures, and a shorter healing duration. The application of antibiotic bone cement is an effective solution for infected DFU treatment.