4.8 Article

Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort

Joseph A. Rothwell et al.

Summary: This study found that adherence to WCRF/AICR guidelines is associated with colorectal cancer risk, and specific changes in metabolites are more strongly associated with risk than the overall WCRF/AICR score.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Oncology

Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis

Neil Murphy et al.

Summary: This study found a causal effect of higher fasting insulin levels on increased colorectal cancer risk, while no significant effect was observed for glucose traits or type 2 diabetes.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2022)

Review Endocrinology & Metabolism

Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies

Jakub Morze et al.

Summary: Based on this updated systematic review and meta-analysis, several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with the risk of type 2 diabetes.

DIABETES CARE (2022)

Article Endocrinology & Metabolism

Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies

Jakub Morze et al.

Summary: An updated systematic review and meta-analysis found that several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with type 2 diabetes risk. However, there were substantial heterogeneity observed for some of the metabolites, indicating the need for further research in this area.

DIABETES CARE (2022)

Article Biochemistry & Molecular Biology

Pre-Diagnostic Circulating Metabolites and Colorectal Cancer Risk in the Cancer Prevention Study-II Nutrition Cohort

Marjorie L. McCullough et al.

Summary: Untargeted metabolomic studies identified several metabolites associated with colorectal cancer risk, including various classes of substances. Five metabolites were positively associated, and one was inversely associated with CRC risk. Further large pooled prospective analyses are needed to confirm or refute these findings and to discover and replicate metabolites associated with colorectal cancer risk.

METABOLITES (2021)

Article Oncology

Investigation of circulating metabolites associated with breast cancer risk by untargeted metabolomics: a case-control study nested within the French E3N cohort

Elodie Jobard et al.

Summary: Perturbations in circulating metabolites were observed in premenopausal but not postmenopausal breast cancer cases. Metabolites such as histidine, N-acetyl glycoproteins, glycerol, and ethanol were associated with breast cancer risk, particularly in the premenopausal subgroup.

BRITISH JOURNAL OF CANCER (2021)

Article Nutrition & Dietetics

Associations between dietary amino acid intakes and blood concentration levels

Isabel Iguacel et al.

Summary: The study found weak positive correlations and dose responses between most essential and conditionally essential AA intake and blood concentrations, but not for non-essential AAs.

CLINICAL NUTRITION (2021)

Article Oncology

Circulating tryptophan metabolites and risk of colon cancer: Results from case-control and prospective cohort studies

Nikos Papadimitriou et al.

Summary: The study found that higher plasma tryptophan levels may be associated with a lower risk of colon cancer, while increased serotonin levels may be linked to a higher risk of colon cancer. Additionally, the kynurenine-to-tryptophan ratio may reflect altered tryptophan metabolism during colon cancer development.

INTERNATIONAL JOURNAL OF CANCER (2021)

Article Biochemistry & Molecular Biology

A Metabolic Model of Intestinal Secretions: The Link between Human Microbiota and Colorectal Cancer Progression

Pejman Salahshouri et al.

Summary: The study highlights the significant impact of alterations in gut microbiome on the development of colorectal cancer, including the potential to provoke mutations and transform adenomas into carcinomas, as well as promote or inhibit cancer progression through influencing metabolites.

METABOLITES (2021)

Article Oncology

Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium

Anne J. M. R. Geijsen et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

Review Biochemistry & Molecular Biology

Amino acids in cancer

Elizabeth L. Lieu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Editorial Material Gastroenterology & Hepatology

Tyrosine and Glutamine-Leucine Are Metabolic Markers of Early-Stage Colorectal Cancers

Jiankang Li et al.

GASTROENTEROLOGY (2019)

Article Biotechnology & Applied Microbiology

Metabolomics Analysis in Serum from Patients with Colorectal Polyp and Colorectal Cancer by 1H-NMR Spectrometry

Jinping Gu et al.

DISEASE MARKERS (2019)

Article Nutrition & Dietetics

Clinical Significance of Serum Glutamine Level in Patients with Colorectal Cancer

Hang Huong Ling et al.

NUTRIENTS (2019)

Article Cardiac & Cardiovascular Systems

High plasma glutamate and low glutamine-to-glutamate ratio are associated with type 2 diabetes: Case-cohort study within the PREDIMED trial

Xiaoran Liu et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2019)

Article Oncology

Plasma metabolites associated with colorectal cancer: A discovery-replication strategy

Anne J. M. R. Geijsen et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Article Multidisciplinary Sciences

Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo

Yiqing Zhao et al.

SCIENTIFIC REPORTS (2019)

Article Oncology

Prospective study of blood metabolites associated with colorectal cancer risk

Xiang Shu et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

Article Gastroenterology & Hepatology

Serum metabolomics analysis for early detection of colorectal cancer

Kazuhiko Uchiyama et al.

JOURNAL OF GASTROENTEROLOGY (2017)

Review Oncology

Dietary Patterns and Colorectal Cancer Risk: a Review of 17 Years of Evidence (2000-2016)

Fred K. Tabung et al.

CURRENT COLORECTAL CANCER REPORTS (2017)

Article Oncology

Glutamine Metabolism in Cancer: Understanding the Heterogeneity

Ahmad A. Cluntun et al.

TRENDS IN CANCER (2017)

Article Medicine, Research & Experimental

Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities

Jermaine Goveia et al.

EMBO MOLECULAR MEDICINE (2016)

Article Multidisciplinary Sciences

Human gut microbes impact host serum metabolome and insulin sensitivity

Helle Krogh Pedersen et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

The gut microbiota modulates host amino acid and glutathione metabolism in mice

Adil Mardinoglu et al.

MOLECULAR SYSTEMS BIOLOGY (2015)

Review Allergy

Histamine and gut mucosal immune regulation

S. Smolinska et al.

ALLERGY (2014)

Article Biochemical Research Methods

Metabonomics Identifies Serum Metabolite Markers of Colorectal Cancer

Binbin Tan et al.

JOURNAL OF PROTEOME RESEARCH (2013)

Article Endocrinology & Metabolism

Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics

Werner Roemisch-Margl et al.

METABOLOMICS (2012)

Article Multidisciplinary Sciences

A Novel Serum Metabolomics-Based Diagnostic Approach for Colorectal Cancer

Shin Nishiumi et al.

PLOS ONE (2012)

Article Health Policy & Services

UK Biobank: Current status and what it means for epidemiology

Naomi Allen et al.

HEALTH POLICY AND TECHNOLOGY (2012)

Article Endocrinology & Metabolism

Diabetes and Cancer A consensus report

Edward Giovannucci et al.

DIABETES CARE (2010)

Review Allergy

Histamine, histamine receptors and their role in immune pathology

M. Jutel et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2009)

Review Gastroenterology & Hepatology

The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas

Edward Govannucci et al.

GASTROENTEROLOGY (2007)

Review Medicine, General & Internal

Colorectal cancer

J Weitz et al.

LANCET (2005)

Article Public, Environmental & Occupational Health

European prospective investigation into cancer and nutrition (EPIC):: study populations and data collection

E Riboli et al.

PUBLIC HEALTH NUTRITION (2002)