4.3 Article

Postoperative serum interleukin-6 levels correlate with survival in stage I-III colorectal cancer

Related references

Note: Only part of the references are listed.
Article Oncology

Targeting stemness of cancer stem cells to fight colorectal cancers

Lei Du et al.

Summary: This review provides an overview of current progress in colorectal cancer stem cell (CCSC) studies, including specific surface markers, intrinsic signaling pathways, and tumor organoid models. The review highlights the potential of targeting CCSCs through monoclonal antibodies, natural or synthetic compounds, or immunotherapy. Combinatory approaches targeting the stemness network may be important for eradicating cancer, considering the heterogeneity and plasticity of CSCs.

SEMINARS IN CANCER BIOLOGY (2022)

Article Oncology

Increased Circulating Levels of CRP and IL-6 and Decreased Frequencies of T and B Lymphocyte Subsets Are Associated With Immune-Related Adverse Events During Combination Therapy With PD-1 Inhibitors for Liver Cancer

Yingying Yu et al.

Summary: This study evaluated the clinical biomarkers associated with immune-related adverse events (irAEs) and found that changes in C-reactive protein (CRP), interleukin-6 (IL-6), and lymphocyte subsets were associated with the occurrence of irAEs. Impairments in liver function and routine blood tests were also observed as important indicators of irAEs.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

The clinical value of C-reactive protein and its association with tumour location in patients undergoing curative surgery for colorectal cancer - a ScotScan collaborative study

Anniken J. Fuglestad et al.

Summary: This study confirms CRP as a strong prognostic marker of SIR in CRC patients, with right-sided tumors more often associated with SIR while the prognostic impact is stronger in left-sided tumors.

ACTA ONCOLOGICA (2022)

Article Surgery

Role of C-Reactive Protein, White Blood Cell Counts, and Serum Glucose Levels as Early Predictors of Infectious Complications After Laparoscopic Colorectal Surgery for Colorectal Cancer

Byung-Soo Park et al.

Summary: This study found that the CRP level on postoperative day 2 and the combined CRP and WBC on postoperative day 4 were effective predictors of infectious complications following laparoscopic colorectal surgery, while serum glucose levels had a low predictive value.

AMERICAN SURGEON (2022)

Article Oncology

Preoperative low absolute lymphocyte count to fibrinogen ratio correlated with poor survival in nonmetastatic colorectal cancer

Xiang Huang et al.

Summary: Preoperative absolute lymphocyte count (LC) and fibrinogen (FIB) are useful prognostic indicators in colorectal cancer (CRC). The LC to FIB ratio (LFR) also serves as a valuable prognostic indicator, with patients having a lower LFR experiencing poorer survival.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2022)

Article Gastroenterology & Hepatology

Impact of severe postoperative inflammatory response on recurrence after curative resection of colorectal cancer

Yuya Nakamura et al.

Summary: This study investigates the prognostic impact of severe postoperative inflammatory response after curative resection of colorectal cancer (CRC). The findings suggest that a severe inflammatory response in the early postoperative period increases the risk of recurrence, with patients having high C-reactive protein (CRP) levels experiencing earlier and persistently higher recurrence hazard than those with low CRP levels.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2022)

Article Oncology

Postoperative, but not preoperative, inflammation-based prognostic markers are prognostic factors in stage III colorectal cancer patients

Kohei Yasui et al.

Summary: This study suggests that postoperative changes in inflammation-based prognostic markers are more accurate in predicting overall survival and recurrence-free survival in patients with stage III CRC. The study found that patients with a normalised inflammatory state had better prognosis compared to those with persistently elevated inflammatory state.

BRITISH JOURNAL OF CANCER (2021)

Article Gastroenterology & Hepatology

The Elevation in Preoperative Procalcitonin Is Associated with a Poor Prognosis for Patients Undergoing Resection for Colorectal Cancer

Toru Miyake et al.

Summary: The study found that high preoperative PCT values in colorectal cancer patients were associated with poor overall survival (OS) but not with relapse-free survival (RFS) following surgical treatments. Additionally, gender, TNM classification, and PCT were identified as significant risk factors for cancer-specific OS in patients with colorectal cancer.

DIGESTIVE SURGERY (2021)

Article Biochemistry & Molecular Biology

IL-6 and IL-8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor

Bun Kim et al.

Summary: The study found that factors released from myofibroblasts may increase CSCs through IL-6/IL-8-induced HES1 activation in the tumor microenvironment, which might be mediated via the Notch/HES1 and STAT3 signaling pathways.

MOLECULAR CARCINOGENESIS (2021)

Article Multidisciplinary Sciences

Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy

Eric H. Bent et al.

Summary: In a mouse model of BCR-ABL(+) B-cell acute lymphoblastic leukemia, chemotherapy-induced anti-cancer immunity is suppressed by the tumor microenvironment through production of cytokine IL-6. IL-6 inhibits the efficacy of immunotherapy and promotes resistance to doxorubicin, impacting CD8(+) T-cell-mediated anti-cancer responses.

NATURE COMMUNICATIONS (2021)

Article Oncology

Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study

Xinwei Hua et al.

Summary: This study utilized a Mendelian randomization approach to assess the association between CRP concentrations and colorectal cancer-specific survival, and found no causal effect of circulating CRP concentrations on colorectal cancer-specific survival. Further research on genetically determined levels of other inflammatory biomarkers is needed for colorectal cancer survival outcomes.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2021)

Article Oncology

Association between post-treatment circulating biomarkers of inflammation and survival among stage II-III colorectal cancer patients

Xinwei Hua et al.

Summary: This study explored the associations of post-treatment inflammatory biomarkers with colorectal cancer survival. Elevated levels of CRP, IL-6, MCP-1, and adiponectin were associated with higher all-cause mortality, while IL-6 remained significant for CRC-specific mortality over 10 years. These findings suggest the potential of post-treatment inflammatory biomarkers, especially IL-6, as promising prognostic markers for stage II-III CRC patients.

BRITISH JOURNAL OF CANCER (2021)

Article Multidisciplinary Sciences

Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer

Thaer S. A. Abdalla et al.

Summary: The detection of circulating tumor cells in patients with colorectal cancer before surgery is an independent and strong prognostic factor for overall survival. This study suggests that it could improve the identification of high-risk patients in future clinical trials.

PLOS ONE (2021)

Article Multidisciplinary Sciences

Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery

Simone Di Franco et al.

Summary: Obesity is identified as a major risk factor for cancer related deaths. Visceral adipose-derived factors activate STAT3, inhibiting miR-200a and enhancing ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.

NATURE COMMUNICATIONS (2021)

Review Oncology

The prognostic utility of pre-treatment neutrophil-to-lymphocyte-ratio (NLR) in colorectal cancer: A systematic review and meta-analysis

Mate Naszai et al.

Summary: Inflammation is closely related to cancer, and NLR from routine blood testing serves as an easily accessible prognostic biomarker, aiding in assessing clinical outcomes in colorectal cancer patients. Combining results from numerous studies, high NLR was found to be associated with poor clinical outcomes, despite limitations in some studies, it should be routinely collected in clinical trials.

CANCER MEDICINE (2021)

Article Oncology

Concurrent Comparison of the Prognostic Values of Tumor Budding, Tumor Stroma Ratio, Tumor Infiltrating Pattern and Lymphocyte-to-Monocyte Ratio in Colorectal Cancer Patients

Yingcheng Zhang et al.

Summary: In colorectal cancer, tumor budding, tumor infiltrating pattern, and preoperative lymphocyte-to-monocyte ratio have been proven to be important prognostic markers for predicting patient survival, with the preoperative lymphocyte-to-monocyte ratio potentially being the most significant independent prognostic factor.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

Article Oncology

The impact of postoperative inflammation on recurrence in patients with colorectal cancer

Daiki Matsubara et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Gastroenterology & Hepatology

Significance of the 7th postoperative day neutrophil-to-lymphocyte ratio in colorectal cancer

Tamuro Hayama et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2020)

Article Gastroenterology & Hepatology

Postoperative Fasting Blood Glucose Predicts Prognosis in Stage I-III Colorectal Cancer Patients Undergoing Resection

Rui Xu et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2020)

Article Oncology

Preoperative neutrophil-to-lymphocyte ratio as a predictive factor for survival in nonmetastatic colorectal cancer

Kaptan Gulben et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2020)

Article Genetics & Heredity

Quantitative evidence for early metastatic seeding in colorectal cancer

Zheng Hu et al.

NATURE GENETICS (2019)

Article Medicine, General & Internal

Effect of Remifentanil Combined Anesthesia on Cytokines and Oxidative Stress in Patients undergoing Laparoscopic Surgery for Colon Cancer

Suchun Ding et al.

JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN (2019)

Article Medicine, General & Internal

Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence

Benjamin Click et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Article Gastroenterology & Hepatology

Incidence and predictors of adenoma after surgery for colorectal cancer

Joana Marques-Antunes et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2017)

Article Gastroenterology & Hepatology

Procalcitonin and C-reactive protein as early markers of postoperative intra-abdominal infection in patients operated on colorectal cancer

E. Dominguez-Comesana et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2017)

Article Gastroenterology & Hepatology

Factors Associated With Recurrence of Advanced Colorectal Adenoma After Endoscopic Resection

Antonio Facciorusso et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2016)

Review Pharmacology & Pharmacy

The bad seed: Cancer stem cells in tumor development and resistance

Elle Koren et al.

DRUG RESISTANCE UPDATES (2016)

Article Oncology

Baseline serum C-reactive protein and death from colorectal cancer in the NHANES III cohort

Helen Swede et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

Article Medicine, General & Internal

Adenoma Detection Rate and Risk of Colorectal Cancer and Death

Douglas A. Corley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Surgery

Prognostic value of circulating cytokines for stage III colon cancer

Won-Suk Lee et al.

JOURNAL OF SURGICAL RESEARCH (2013)

Article Pathology

Cytotoxic T Lymphocytes Efficiently Recognize Human Colon Cancer Stem-Like Cells

Satoko Inoda et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Medical Laboratory Technology

Serum interleukin 6 (IL-6) and C-reactive protein (CRP) levels in colorectal adenoma and cancer patients

Magdalena Groblewska et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2008)

Review Multidisciplinary Sciences

Cancer-related inflammation

Alberto Mantovani et al.

NATURE (2008)

Review Medicine, General & Internal

Drug therapy - Systemic therapy for colorectal cancer

JA Meyerhardt et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Review Multidisciplinary Sciences

Inflammation and cancer

LM Coussens et al.

NATURE (2002)

Article Gastroenterology & Hepatology

Systemic interleukin-6 response to colorectal surgery originates from the bowel

I Syk et al.

DIGESTIVE SURGERY (2002)

Article Surgery

Changes in T cell subsets, interleukin-6, and C-reactive protein after laparoscopic and open colorectal resection for malignancy

BJ Mehigan et al.

SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES (2001)