4.6 Article

EBV antibody and gastric cancer risk: a population-based nested case-control study in southern China

Journal

BMC CANCER
Volume 23, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s12885-023-10994-0

Keywords

Gastric cancer; EBNA1-IgA; VCA-IgA; Nested case-control study; Population-based

Categories

Ask authors/readers for more resources

Our study found positive associations between EBNA1-IgA and VCA-IgA and gastric cancer risk in southern China. These results suggest that EBNA1-IgA and VCA-IgA could potentially serve as biomarkers for gastric cancer.
BackgroundWe aim to clarify the controversial associations between EBV-related antibodies and gastric cancer risk.MethodsWe analysed the associations between serological Epstein-Barr nuclear antigen 1 immunoglobulin A (EBNA1-IgA) and viral capsid antigen immunoglobulin A (VCA-IgA) by enzyme-linked immunosorbent assay and the risk of gastric cancer in a nested case-control study originated from a population-based nasopharyngeal carcinoma (NPC) screening cohort in Zhongshan, a city of southern China, including 18 gastric cancer cases and 444 controls. Conditional logistic regression was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs).ResultsAll the sera of cases were sampled before diagnosis and the median time interval was 3.04 (range: 0.04, 7.59) years. Both increased relative optical density (rOD) values of EBNA1-IgA and VCA-IgA were associated with higher risks of gastric cancer with age adjusted ORs of 1.99 (95%CI: 1.07, 3.70) and 2.64 (95%CI: 1.33, 5.23), respectively. Each participant was further classified as high or medium/low risk based on a combination of two anti-EBV antibody levels. Participants in the high-risk group had substantially higher odds of developing gastric cancer than that in the medium/low risk group with an age adjusted OR of 6.53 (95%CI: 1.69, 25.26).ConclusionsOur research reveals positive associations between EBNA1-IgA and VCA-IgA and gastric cancer risk in southern China. We thus postulate that EBNA1-IgA and VCA-IgA might appear to be potential biomarkers for gastric cancer. More research to further validate the results among diverse populations and investigate its underlying biological mechanism is needed.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available