Is obesity a risk factor for melanoma?

ObjectivesAre twofold: 1) to estimate the relationship between obesity (BMI >= 30) and the prevalence of melanoma in different US states and 2) to examine the possibility of defining a new risk group. This might enhance the possibility of detection, which in turn, might increase the survival rates of patients.Study designA cohort Study, based on data at the US statewide level in 2011-2017, where the dependent variable (the annual new melanoma cases per 100,000 persons) is adjusted for age.MethodQuadratic regression analysis. This model permits a non-monotonic variation of obesity with new melanoma cases adjusted for age, where the control variable is the level of UV radiation.ResultsDemonstrate a negative correlation between obesity and incidence of melanoma. This outcome is further corroborated for Caucasians.ConclusionsWe should continue to establish primary prevention of melanoma by raising photo protection awareness and secondary prevention by promoting skin screening (by physician or self) among the entire population group in all BMI ranges. Advanced secondary melanoma prevention including noninvasive diagnosis strategies including total body photography, confocal microscopy, AI strategies should focus the high-risk sub group of Caucasians with BMI < 30.

Automated summary

The objectives of this study are to estimate the relationship between obesity (BMI >= 30) and the prevalence of melanoma in different US states, and to examine the possibility of defining a new risk group. The results show a negative correlation between obesity and the incidence of melanoma, especially in the high-risk Caucasian subgroup. It is concluded that primary prevention and secondary prevention measures should be continued, including raising awareness of photoprotection and promoting skin screening among the entire population group, with a focus on the high-risk Caucasian subgroup with BMI < 30.