TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression

Article Oncology

Tubulin alpha 1c promotes aerobic glycolysis and cell growth through upregulation of yes association protein expression in breast cancer

Zhu Wu et al.

Summary: The study reveals that TUBA1C is overexpressed in breast cancer and promotes aerobic glycolysis and cell growth through upregulation of YAP expression.

ANTI-CANCER DRUGS (2022)

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Article Biochemistry & Molecular Biology

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

Yasset Perez-Riverol et al.

Summary: PRIDE is the largest data repository of mass spectrometry-based proteomics data in the world, with around 500 datasets submitted per month. In addition to continuous improvements in data pipelines and infrastructure, PRIDE has developed the Spectra Archive and MAGE-TAB file format to enhance sample metadata annotation and access to mass spectra.

NUCLEIC ACIDS RESEARCH (2022)

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Article Cell Biology

The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis

Dandan Li et al.

Summary: The abnormal expression of NR2F1-AS1 in gastric cancer is related to its correlation with NR2F1 expression, as well as their response to epithelial-to-mesenchymal transition signaling. NR2F1-AS1 modulates the miR-29a-3p/VAMP7 axis and plays a crucial role in the progression of gastric cancer.

CELL DEATH & DISEASE (2022)

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Article Oncology

LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex

Dandan Li et al.

Summary: This study reveals the SNAI2-ELF3-AS1 feedback loop that regulates the expression of ELF3 at transcriptional and post-transcriptional levels, driving gastric cancer metastasis by maintaining SNAI2 overexpression. Additionally, the study provides direct evidence that head-to-head antisense lncRNAs can share promoters with neighboring coding genes, resulting in high co-expression.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Immunology

Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2

Shanshan Qin et al.

Summary: In this study, it was found that the serine protease PRSS23 promotes tumor-associated macrophage infiltration in gastric cancer by regulating the expression and secretion of FGF2, resulting in a poor prognosis.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Using a comprehensive approach to investigate the interaction between Kinesin-5/Eg5 and the microtubule

Wenhan Guo et al.

Summary: In this study, the interaction between human Kinesin-5 and microtubule was systematically studied using molecular dynamics simulations and other computational approaches. The findings suggest that the electrostatic features on the Eg5 motor domain provide attractive interactions to the microtubule. Additionally, analysis of folding and binding energy reveals that the Eg5 motor domain functions best in a weak acidic environment.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

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Article Biochemistry & Molecular Biology

TUBA1C expression promotes proliferation by regulating the cell cycle and indicates poor prognosis in glioma

Shikai Gui et al.

Summary: This study identified that high TUBA1C expression correlates with poor outcomes in glioma patients, and knocking down TUBA1C can suppress glioma cell proliferation via cell cycle arrest, potentially serving as a therapeutic biomarker.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Review Biochemistry & Molecular Biology

The Functions and Unique Features of LncRNAs in Cancer Development and Tumorigenesis

Kenzui Taniue et al.

Summary: Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides without protein-coding potential, and have been shown to be associated with human diseases like cancer. They interact with cellular macromolecules such as DNA, protein, and RNA to contribute to various important cancer phenotypes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram

Dexin Chen et al.

Summary: A collagen signature derived from multiphoton imaging in the tumor microenvironment of the gastric serosa is significantly associated with a high risk of peritoneal metastasis in gastric cancer with serosal invasion. A competing-risk nomogram including the collagen signature, tumor size, tumor differentiation status, and lymph node metastasis demonstrates satisfactory discrimination and calibration, providing a convenient way to predict the risk of peritoneal metastasis in gastric cancer with serosal invasion after radical surgery.

NATURE COMMUNICATIONS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Prognostic biomarker TUBA1C is correlated to immune cell infiltration in the tumor microenvironment of lung adenocarcinoma

Tingting Bian et al.

Summary: The mRNA and protein expression of TUBA1C is up-regulated in LUAD tissues, and its over-expression is associated with poor prognosis. TUBA1C is correlated with various tumor-infiltrating immune cells and is closely related to several important biological pathways in cancer.

CANCER CELL INTERNATIONAL (2021)

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Article Cell Biology

A new candidate oncogenic lncRNA derived from pseudogene WFDC21P promotes tumor progression in gastric cancer

Huaiping Cui et al.

Summary: In this study, a novel lncRNA WFDC21P derived from pseudogenes was identified and found to promote proliferation and metastasis of gastric cancer cells by activating the Akt/GSK3 beta/beta-catenin pathway. It may serve as a potential biomarker and therapeutic target for gastric cancer.

CELL DEATH & DISEASE (2021)

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Article Genetics & Heredity

TUBA1C is a Prognostic Marker in Low-grade Glioma and Correlates with Immune Cell Infiltration in the Tumor Microenvironment

Hua Zhu et al.

Summary: TUBA1C expression is upregulated in LGG and high expression is associated with poor prognosis, potentially influencing tumor development by regulating tumor-infiltrating cells. TUBA1C may serve as a potential target for immunotherapy.

FRONTIERS IN GENETICS (2021)

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Article Biochemistry & Molecular Biology

The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA-RNA interactions and drives gastric cancer metastasis via miR-138-5p/ITGA2 axis

Dandan Li et al.

Summary: The overexpression of lncRNA UBE2CP3 in gastric cancer promotes tumor progression through modulation of the miR-138-5p/ITGA2 axis. This suggests that UBE2CP3 may serve as a potential therapeutic target in gastric cancer.

ONCOGENE (2021)

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Review Cell Biology