CD53 sends HSCs to sweet DREAMs

In this issue of Blood, Greenberg et al1 show that hematopoietic stem cells (HSCs) employ a novel mechanism via promotion of the CD53-mediated dimerization partner, Rb-like, E2F and multi-vulval class B (DREAM) com-plex to return to quiescence after inflammatory and proliferative stress, thereby protecting them from functional decline.

Automated summary

In this study, Greenberg et al. demonstrate that hematopoietic stem cells (HSCs) utilize a novel mechanism involving the CD53-mediated dimerization partner, Rb-like, E2F and multi-vulval class B (DREAM) complex to revert to a quiescent state after exposure to inflammatory and proliferative stress, thus safeguarding their functional integrity.