4.8 Article

An electrochemical sensor for direct and sensitive detection of ketamine

Journal

BIOSENSORS & BIOELECTRONICS
Volume 226, Issue -, Pages -

Publisher

ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2023.115134

Keywords

Ketamine; L-cysteine; Molecularly imprinted sensor; Oxidation mechanism; Direct determination

Ask authors/readers for more resources

We propose an electrochemical sensor based on a weakly conductive poly-L-cysteine molecularly imprinted membrane for the direct detection of ketamine. The sensor demonstrates excellent detection sensitivity and shows a linear response to ketamine within a certain concentration range. It exhibits high selectivity, sensitivity, and stability, making it reliable for the detection of ketamine in hair and urine samples with high recovery rates.
Ketamine is an organic drug with weak electrochemical activity, which makes it difficult to directly detect by electrochemical methods. Herein, an electrochemical sensor, with excellent detection sensitivity, is proposed for direct detection of ketamine based on a weakly conductive poly-L-cysteine molecularly imprinted membrane. Poly-L-cysteine molecularly imprinted membrane sensor (poly-L-Cys-KT-MIM/GCE) is obtained using L-cysteine as a functional monomer and ketamine as a template molecule based on electropolymerization. The green and highly active cysteine is selected as a functional monomer during electropolymerization, which cannot only achieve specific recognition but also improve detection sensitivity. Furthermore, the oxidation mechanism and fingerprint of ketamine on the electrode surface are established by analyzing the corresponding oxidation products using high/resolution mass spectrometry, which will help to promote the application of electrochem-istry in the rapid detection of drugs. Under optimal conditions, the as-designed sensor demonstrated a linear response to ketamine within the range of 5.0 x 10-7 to 2.0 x 10-5 mol L-1 and a detection limit of 1.6 x 10-7 mol L-1. The proposed method exhibited excellent performance from the viewpoints of selectivity, sensitivity and stability. Notably, the sensor rendered excellent reliability and could be used for the detection of target analytes in hair and urine samples with high recovery rates.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available