Polyoxometalate-cyclodextrin supramolecular entities for real-time in situ monitoring of dopamine released from neuroblastoma cells

Optimized and sensitive biomarker detection has recently been shown to have a critical impact on quality of diagnosis and medical care options. In this research study, polyoxometalate-& gamma;-cyclodextrin metal-organic framework (POM & gamma;CD MOF) was utilized as an electrocatalyst to fabricate highly selective sensors to detect insitu released dopamine. The POM & gamma;CD MOF produced multiple modes of signals for dopamine including electrochemical, colorimetric, and smartphone read-outs. Real-time quantitative monitoring of SH-SY5Y neuroblastoma cellular dopamine production was successfully demonstrated under various stimuli at different time intervals. The POM-CD MOF sensor and linear regression model were used to develop a smartphone read-out platform, which converts dopamine visual signals to digital signals within a few seconds. Ultimately, POM & gamma;CD MOFs can play a significant role in the diagnosis and treatment of various diseases that involve dopamine as a significant biomarker.

Automated summary

In this study, a polyoxometalate-γ-cyclodextrin metal-organic framework (POM γCD MOF) was used as an electrocatalyst to create highly selective sensors for dopamine detection. The POM γCD MOF generated multiple signals for dopamine, including electrochemical, colorimetric, and smartphone read-outs. This research has the potential to significantly impact the diagnosis and treatment of dopamine-related diseases.