Mesoscale simulations: An indispensable approach to understand biomembranes

Computer simulation techniques form a versatile tool, a computational microscope, for exploring biological processes. This tool has been particularly effective in exploring different features of biological membranes. In recent years, thanks to elegant multiscale simulation schemes, some fundamental limitations of investigations by distinct simulation techniques have been resolved. As a result, we are now capable of exploring processes spanning multiple scales beyond the capacity of any single technique. In this perspective, we argue that mesoscale simulations require more attention and must be further developed to fill evident gaps in a quest toward simulating and modeling living cell membranes.

Automated summary

Computer simulation techniques are a versatile tool for exploring biological processes, especially the features of biological membranes. Recent advances in multiscale simulation schemes have overcome the limitations of traditional simulation techniques, allowing us to study processes that span multiple scales beyond the capacity of any single technique. Therefore, we argue that mesoscale simulations require more attention and further development to bridge the evident gaps in simulating and modeling living cell membranes.