4.7 Article

Structure optimization of an F-indole-chalcone (FC116) on 4-methoxy-phenyl group and therapeutic potential against colorectal cancers with low cytotoxicity

Related references

Note: Only part of the references are listed.
Review Oncology

New developments in targeted therapy for metastatic colorectal cancer

Ambrose H. N. Wong et al.

Summary: Colorectal cancer (CRC) is the second most lethal cancer worldwide, and recent advancements in translational research have led to improved treatment outcomes for patients with specific mutations. Understanding resistance mechanisms and the use of ctDNA for therapeutic monitoring have provided new insights for individualized treatment. The feasibility of 'Master Protocols' utilizing ctDNA-based genotyping platforms is being evaluated to broaden the implementation of precision oncology.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2023)

Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Medicine, General & Internal

Cancer statistics in China and United States, 2022: profiles, trends, and determinants

Changfa Xia et al.

Summary: The study compared the latest cancer profiles, trends, and determinants between China and the USA in 2022. China has a higher incidence of lung cancer, while the USA has more cases of breast cancer. Recent years have seen a significant decrease in lung and colorectal cancer rates in the USA, while liver cancer rates have slightly increased. In China, rates for stomach, liver, and esophageal cancer have decreased gradually, but colorectal cancer rates have increased for the whole population.

CHINESE MEDICAL JOURNAL (2022)

Review Oncology

Exploring immunotherapy in colorectal cancer

Junyong Weng et al.

Summary: Immunotherapy with immune checkpoint blockade has shown progress in the treatment of metastatic colorectal cancer (mCRC), although its effectiveness is limited. This review summarizes treatment strategies, discusses the mechanism and application of immune checkpoint blockade in mCRC treatment, and provides the latest research and clinical trial results.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Article Oncology

Colon Cancer, Version 2.2021

Al B. Benson et al.

Summary: This section of the NCCN Clinical Practice Guidelines in Oncology focuses on systemic therapy options for metastatic colorectal cancer, with important updates including first-line use of checkpoint inhibitors and expanded recommendations for biomarker testing.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

Review Cell Biology

Microtubule-targeting agents and their impact on cancer treatment

Vladimir Cermak et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2020)

Article Medicine, Research & Experimental

An Indole-Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules

Hui Cong et al.

MOLECULAR PHARMACEUTICS (2018)

Review Chemistry, Multidisciplinary

Chalcone: A Privileged Structure in Medicinal Chemistry

Chunlin Zhuang et al.

CHEMICAL REVIEWS (2017)

Article Biochemistry & Molecular Biology

Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs

M. Hugle et al.

CELL DEATH AND DIFFERENTIATION (2015)

Review Oncology

Therapeutic strategy in unresectable metastatic colorectal cancer: an updated review

Benoist Chibaudel et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2015)

Review Gastroenterology & Hepatology

The role of chemotherapy in microsatellite unstable (MSI-H) colorectal cancer

Janindra Warusavitarne et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2007)

Review Medicine, General & Internal

Colorectal cancer

J Weitz et al.

LANCET (2005)

Review Oncology

Molecular mechanisms of drug resistance

DB Longley et al.

JOURNAL OF PATHOLOGY (2005)